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Chaga
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Chaga mushroom (Inonotus obliquus) is a dense source of antioxidants, betulinic acid, and immune-modulating compounds. Grown on birch trees, this “King of Medicinal Mushrooms” supports DNA repair, cellular defense, and oxidative stress reduction.
Chaga also nourishes skin, balances inflammation, and helps neutralize environmental toxins—making it a powerful tool for modern detox and longevity.
Supplement Facts
Other Ingredients: Vegetable Cellulose (Veggie Capsule)
Take 1 capsule daily or and use consistently for best results.
Every Organica product is crafted with a purity-first promise—100% plant-based, vegan, and free from GMOs, fillers, and artificial additives. Each batch is third-party tested to ensure clean, effective wellness you can trust in every capsule.
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Rooted Wellness and Resilient Living
Balances Cholesterol Levels
Helps balance high cholesterol and support healthy lipid levels with natural, heart-protective compounds.
Reduces Inflammation Naturally
Helps regulate internal systems and supports a calm, steady response to everyday physical demands.
Strengthens Immune Defense
Helps fortify your body’s frontline defenses against seasonal threats and environmental stressors.
Rooted Wellness and Resilient Living
Strengthens Immune Defense
Helps fortify your body’s frontline defenses against seasonal threats and environmental stressors.
Balances Cholesterol Levels
Helps balance high cholesterol and support healthy lipid levels with natural, heart-protective compounds.
Reduces Inflammation Naturally
Helps regulate internal systems and supports a calm, steady response to everyday physical demands.
Main Ingredients
Chaga
Organica’s Chaga capsules deliver a clinically standardized Inonotus obliquus extract shown in studies to activate immune.
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Chaga
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Origin:
Chaga (Inonotus obliquus) is a sterile conk that grows primarily on birch in cold climates. Traditionally decocted in Russia and parts of Asia, modern supplements use fruiting-body extracts or hot-water/ethanolic concentrates standardized to β-glucans, polyphenols/melanin, and betulin/ betulinic acid (birch-derived triterpenes).
How it works
Chaga polysaccharides (β-glucans) prime innate immunity (dectin-1/TLR pathways), while phenolics/melanin provide ROS-scavenging and Nrf2/HO-1 antioxidant support. Triterpenes (betulin/betulinic acid) and polyphenols can modulate NF-κB/COX-2 inflammatory signaling. These mechanisms align with reports of immune modulation, inflammation marker improvements, and favorable lipid/glucose signals in early human and preclinical research.
Top 5 Clinically Supported Benefits
1) Immunity (immune modulation)
Randomized and controlled human studies with Chaga polysaccharide–rich extracts report modulation of immune cell activity and cytokine balance in healthy and stressed adults.
Study chips: Standardized polysaccharides; 4–12 weeks; endpoints: NK activity/cytokines/WBC subsets; DB-RCTs & pilots.
2) Inflammation (marker modulation)
Human pilots and adjunct studies show directional reductions in inflammatory markers (e.g., CRP/TNF-α/IL-6) and improved symptom scores—consistent with NF-κB/COX-2 down-regulation seen preclinically.
Study chips: Fruiting-body extracts; 6–12 weeks; endpoints: CRP/cytokines; designs vary.
3) Cholesterol & Lipids
Animal and early clinical data suggest support for healthier lipid profiles (total/LDL cholesterol), plausibly via bile acid metabolism and antioxidant protection of lipids. Human data remain preliminary.
Study chips: Hot-water/ethanol extracts; 8–12 weeks; endpoints: TC/LDL/HDL/TG.
4) Antioxidant Capacity
Small human studies and multiple preclinical papers report higher total antioxidant capacity (TAC) and upregulated SOD/GPx, reflecting Chaga’s polyphenol/melanin content.
Study chips: 4–8 weeks; endpoints: TAC, SOD/GPx, TBARS; randomized/controlled or crossover.
5) Glycemic/Metabolic Support (preliminary human data)
Early human work with Chaga-type polysaccharides and triterpene-rich extracts shows signals for improved fasting glucose/insulin sensitivity, aligning with mechanisms seen in animal models.
Study chips: 8–12 weeks; endpoints: FPG, HOMA-IR/HbA1c; pilot RCTs; confirmation needed.
Summary
Evidence to date—small RCTs/pilots plus robust mechanistic and preclinical research—suggests Chaga can modulate immune function, temper inflammatory signaling, support healthier lipids, and raise antioxidant capacity, with early metabolic benefits emerging. For credible translation, use fruiting-body–based extracts standardized to β-glucans (and characterized for polyphenols/triterpenes) for 4–12 weeks of consistent use.
Why choose Organica to reach those outcomes
- Clinically aligned standardization: fruiting-body Chaga with declared β-glucans and characterized phenolics/triterpenes.
- Third-party COA: species ID, β-glucans (enzymatic), phenolics/triterpenes (HPLC/UPLC), plus heavy metals, microbes, pesticides, solvents.
- cGMP, small-batch, vegan capsules; clean excipients; supplier traceability to birch-grown material.
Safety note (important): Chaga is naturally high in oxalates. Not advised for individuals with kidney stone risk or kidney disease. Avoid with anticoagulants unless supervised. Not for pregnancy/nursing.
References (MIT style, URLs shown as text only)
- Shashkina, M. Y., Shashkin, P. N., & Sergeev, A. V. “Chemical and medicobiological properties of chaga (Inonotus obliquus).” Pharmaceutical Chemistry Journal (review).
https://link.springer.com/journal/11094(search title) - Vetvicka, V., & Vetvickova, J. “β-Glucans in promoting health: immune effects and clinical perspective.” International Journal of Medicinal Mushrooms.
https://www.begellhouse.com/journals/(search: “β-glucans chaga review”) - Song, F., et al. “Melanin, phenolics, and antioxidant activities from Inonotus obliquus.” Molecules (MDPI).
https://www.mdpi.com/journal/molecules(search title) - Wang, J., et al. “Anti-inflammatory and NF-κB–modulating effects of Inonotus obliquus extracts.” Journal of Ethnopharmacology.
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology(search title) - Kim, Y., et al. “Effects of Inonotus obliquus on lipid metabolism and oxidative stress.” Nutrients / Food & Function (reviews and preclinical summaries).
https://www.mdpi.com/journal/nutrients•https://pubs.rsc.org/en/journals/journal/fo(search titles) - Zhang, X., et al. “Hypoglycemic and insulin-sensitizing effects of Chaga polysaccharides.” Frontiers in Pharmacology (review).
https://www.frontiersin.org/journals/pharmacology(search title)
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take medications (especially anticoagulants), consult a clinician before use.
Chaga
Organica’s Chaga capsules deliver a clinically standardized Inonotus obliquus extract shown in studies to activate immune.
Chaga
Origin:
Chaga (Inonotus obliquus) is a sterile conk that grows primarily on birch in cold climates. Traditionally decocted in Russia and parts of Asia, modern supplements use fruiting-body extracts or hot-water/ethanolic concentrates standardized to β-glucans, polyphenols/melanin, and betulin/ betulinic acid (birch-derived triterpenes).
How it works
Chaga polysaccharides (β-glucans) prime innate immunity (dectin-1/TLR pathways), while phenolics/melanin provide ROS-scavenging and Nrf2/HO-1 antioxidant support. Triterpenes (betulin/betulinic acid) and polyphenols can modulate NF-κB/COX-2 inflammatory signaling. These mechanisms align with reports of immune modulation, inflammation marker improvements, and favorable lipid/glucose signals in early human and preclinical research.
Top 5 Clinically Supported Benefits
1) Immunity (immune modulation)
Randomized and controlled human studies with Chaga polysaccharide–rich extracts report modulation of immune cell activity and cytokine balance in healthy and stressed adults.
Study chips: Standardized polysaccharides; 4–12 weeks; endpoints: NK activity/cytokines/WBC subsets; DB-RCTs & pilots.
2) Inflammation (marker modulation)
Human pilots and adjunct studies show directional reductions in inflammatory markers (e.g., CRP/TNF-α/IL-6) and improved symptom scores—consistent with NF-κB/COX-2 down-regulation seen preclinically.
Study chips: Fruiting-body extracts; 6–12 weeks; endpoints: CRP/cytokines; designs vary.
3) Cholesterol & Lipids
Animal and early clinical data suggest support for healthier lipid profiles (total/LDL cholesterol), plausibly via bile acid metabolism and antioxidant protection of lipids. Human data remain preliminary.
Study chips: Hot-water/ethanol extracts; 8–12 weeks; endpoints: TC/LDL/HDL/TG.
4) Antioxidant Capacity
Small human studies and multiple preclinical papers report higher total antioxidant capacity (TAC) and upregulated SOD/GPx, reflecting Chaga’s polyphenol/melanin content.
Study chips: 4–8 weeks; endpoints: TAC, SOD/GPx, TBARS; randomized/controlled or crossover.
5) Glycemic/Metabolic Support (preliminary human data)
Early human work with Chaga-type polysaccharides and triterpene-rich extracts shows signals for improved fasting glucose/insulin sensitivity, aligning with mechanisms seen in animal models.
Study chips: 8–12 weeks; endpoints: FPG, HOMA-IR/HbA1c; pilot RCTs; confirmation needed.
Summary
Evidence to date—small RCTs/pilots plus robust mechanistic and preclinical research—suggests Chaga can modulate immune function, temper inflammatory signaling, support healthier lipids, and raise antioxidant capacity, with early metabolic benefits emerging. For credible translation, use fruiting-body–based extracts standardized to β-glucans (and characterized for polyphenols/triterpenes) for 4–12 weeks of consistent use.
Why choose Organica to reach those outcomes
- Clinically aligned standardization: fruiting-body Chaga with declared β-glucans and characterized phenolics/triterpenes.
- Third-party COA: species ID, β-glucans (enzymatic), phenolics/triterpenes (HPLC/UPLC), plus heavy metals, microbes, pesticides, solvents.
- cGMP, small-batch, vegan capsules; clean excipients; supplier traceability to birch-grown material.
Safety note (important): Chaga is naturally high in oxalates. Not advised for individuals with kidney stone risk or kidney disease. Avoid with anticoagulants unless supervised. Not for pregnancy/nursing.
References (MIT style, URLs shown as text only)
- Shashkina, M. Y., Shashkin, P. N., & Sergeev, A. V. “Chemical and medicobiological properties of chaga (Inonotus obliquus).” Pharmaceutical Chemistry Journal (review).
https://link.springer.com/journal/11094(search title) - Vetvicka, V., & Vetvickova, J. “β-Glucans in promoting health: immune effects and clinical perspective.” International Journal of Medicinal Mushrooms.
https://www.begellhouse.com/journals/(search: “β-glucans chaga review”) - Song, F., et al. “Melanin, phenolics, and antioxidant activities from Inonotus obliquus.” Molecules (MDPI).
https://www.mdpi.com/journal/molecules(search title) - Wang, J., et al. “Anti-inflammatory and NF-κB–modulating effects of Inonotus obliquus extracts.” Journal of Ethnopharmacology.
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology(search title) - Kim, Y., et al. “Effects of Inonotus obliquus on lipid metabolism and oxidative stress.” Nutrients / Food & Function (reviews and preclinical summaries).
https://www.mdpi.com/journal/nutrients•https://pubs.rsc.org/en/journals/journal/fo(search titles) - Zhang, X., et al. “Hypoglycemic and insulin-sensitizing effects of Chaga polysaccharides.” Frontiers in Pharmacology (review).
https://www.frontiersin.org/journals/pharmacology(search title)
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take medications (especially anticoagulants), consult a clinician before use.
Chaga
Organica’s Chaga capsules deliver a clinically standardized Inonotus obliquus extract shown in studies to activate immune.
Chaga
Origin:
Chaga (Inonotus obliquus) is a sterile conk that grows primarily on birch in cold climates. Traditionally decocted in Russia and parts of Asia, modern supplements use fruiting-body extracts or hot-water/ethanolic concentrates standardized to β-glucans, polyphenols/melanin, and betulin/ betulinic acid (birch-derived triterpenes).
How it works
Chaga polysaccharides (β-glucans) prime innate immunity (dectin-1/TLR pathways), while phenolics/melanin provide ROS-scavenging and Nrf2/HO-1 antioxidant support. Triterpenes (betulin/betulinic acid) and polyphenols can modulate NF-κB/COX-2 inflammatory signaling. These mechanisms align with reports of immune modulation, inflammation marker improvements, and favorable lipid/glucose signals in early human and preclinical research.
Top 5 Clinically Supported Benefits
1) Immunity (immune modulation)
Randomized and controlled human studies with Chaga polysaccharide–rich extracts report modulation of immune cell activity and cytokine balance in healthy and stressed adults.
Study chips: Standardized polysaccharides; 4–12 weeks; endpoints: NK activity/cytokines/WBC subsets; DB-RCTs & pilots.
2) Inflammation (marker modulation)
Human pilots and adjunct studies show directional reductions in inflammatory markers (e.g., CRP/TNF-α/IL-6) and improved symptom scores—consistent with NF-κB/COX-2 down-regulation seen preclinically.
Study chips: Fruiting-body extracts; 6–12 weeks; endpoints: CRP/cytokines; designs vary.
3) Cholesterol & Lipids
Animal and early clinical data suggest support for healthier lipid profiles (total/LDL cholesterol), plausibly via bile acid metabolism and antioxidant protection of lipids. Human data remain preliminary.
Study chips: Hot-water/ethanol extracts; 8–12 weeks; endpoints: TC/LDL/HDL/TG.
4) Antioxidant Capacity
Small human studies and multiple preclinical papers report higher total antioxidant capacity (TAC) and upregulated SOD/GPx, reflecting Chaga’s polyphenol/melanin content.
Study chips: 4–8 weeks; endpoints: TAC, SOD/GPx, TBARS; randomized/controlled or crossover.
5) Glycemic/Metabolic Support (preliminary human data)
Early human work with Chaga-type polysaccharides and triterpene-rich extracts shows signals for improved fasting glucose/insulin sensitivity, aligning with mechanisms seen in animal models.
Study chips: 8–12 weeks; endpoints: FPG, HOMA-IR/HbA1c; pilot RCTs; confirmation needed.
Summary
Evidence to date—small RCTs/pilots plus robust mechanistic and preclinical research—suggests Chaga can modulate immune function, temper inflammatory signaling, support healthier lipids, and raise antioxidant capacity, with early metabolic benefits emerging. For credible translation, use fruiting-body–based extracts standardized to β-glucans (and characterized for polyphenols/triterpenes) for 4–12 weeks of consistent use.
Why choose Organica to reach those outcomes
- Clinically aligned standardization: fruiting-body Chaga with declared β-glucans and characterized phenolics/triterpenes.
- Third-party COA: species ID, β-glucans (enzymatic), phenolics/triterpenes (HPLC/UPLC), plus heavy metals, microbes, pesticides, solvents.
- cGMP, small-batch, vegan capsules; clean excipients; supplier traceability to birch-grown material.
Safety note (important): Chaga is naturally high in oxalates. Not advised for individuals with kidney stone risk or kidney disease. Avoid with anticoagulants unless supervised. Not for pregnancy/nursing.
References (MIT style, URLs shown as text only)
- Shashkina, M. Y., Shashkin, P. N., & Sergeev, A. V. “Chemical and medicobiological properties of chaga (Inonotus obliquus).” Pharmaceutical Chemistry Journal (review).
https://link.springer.com/journal/11094(search title) - Vetvicka, V., & Vetvickova, J. “β-Glucans in promoting health: immune effects and clinical perspective.” International Journal of Medicinal Mushrooms.
https://www.begellhouse.com/journals/(search: “β-glucans chaga review”) - Song, F., et al. “Melanin, phenolics, and antioxidant activities from Inonotus obliquus.” Molecules (MDPI).
https://www.mdpi.com/journal/molecules(search title) - Wang, J., et al. “Anti-inflammatory and NF-κB–modulating effects of Inonotus obliquus extracts.” Journal of Ethnopharmacology.
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology(search title) - Kim, Y., et al. “Effects of Inonotus obliquus on lipid metabolism and oxidative stress.” Nutrients / Food & Function (reviews and preclinical summaries).
https://www.mdpi.com/journal/nutrients•https://pubs.rsc.org/en/journals/journal/fo(search titles) - Zhang, X., et al. “Hypoglycemic and insulin-sensitizing effects of Chaga polysaccharides.” Frontiers in Pharmacology (review).
https://www.frontiersin.org/journals/pharmacology(search title)
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take medications (especially anticoagulants), consult a clinician before use.
Chaga
Organica’s Chaga capsules deliver a clinically standardized Inonotus obliquus extract shown in studies to activate immune.
Chaga
Origin:
Chaga (Inonotus obliquus) is a sterile conk that grows primarily on birch in cold climates. Traditionally decocted in Russia and parts of Asia, modern supplements use fruiting-body extracts or hot-water/ethanolic concentrates standardized to β-glucans, polyphenols/melanin, and betulin/ betulinic acid (birch-derived triterpenes).
How it works
Chaga polysaccharides (β-glucans) prime innate immunity (dectin-1/TLR pathways), while phenolics/melanin provide ROS-scavenging and Nrf2/HO-1 antioxidant support. Triterpenes (betulin/betulinic acid) and polyphenols can modulate NF-κB/COX-2 inflammatory signaling. These mechanisms align with reports of immune modulation, inflammation marker improvements, and favorable lipid/glucose signals in early human and preclinical research.
Top 5 Clinically Supported Benefits
1) Immunity (immune modulation)
Randomized and controlled human studies with Chaga polysaccharide–rich extracts report modulation of immune cell activity and cytokine balance in healthy and stressed adults.
Study chips: Standardized polysaccharides; 4–12 weeks; endpoints: NK activity/cytokines/WBC subsets; DB-RCTs & pilots.
2) Inflammation (marker modulation)
Human pilots and adjunct studies show directional reductions in inflammatory markers (e.g., CRP/TNF-α/IL-6) and improved symptom scores—consistent with NF-κB/COX-2 down-regulation seen preclinically.
Study chips: Fruiting-body extracts; 6–12 weeks; endpoints: CRP/cytokines; designs vary.
3) Cholesterol & Lipids
Animal and early clinical data suggest support for healthier lipid profiles (total/LDL cholesterol), plausibly via bile acid metabolism and antioxidant protection of lipids. Human data remain preliminary.
Study chips: Hot-water/ethanol extracts; 8–12 weeks; endpoints: TC/LDL/HDL/TG.
4) Antioxidant Capacity
Small human studies and multiple preclinical papers report higher total antioxidant capacity (TAC) and upregulated SOD/GPx, reflecting Chaga’s polyphenol/melanin content.
Study chips: 4–8 weeks; endpoints: TAC, SOD/GPx, TBARS; randomized/controlled or crossover.
5) Glycemic/Metabolic Support (preliminary human data)
Early human work with Chaga-type polysaccharides and triterpene-rich extracts shows signals for improved fasting glucose/insulin sensitivity, aligning with mechanisms seen in animal models.
Study chips: 8–12 weeks; endpoints: FPG, HOMA-IR/HbA1c; pilot RCTs; confirmation needed.
Summary
Evidence to date—small RCTs/pilots plus robust mechanistic and preclinical research—suggests Chaga can modulate immune function, temper inflammatory signaling, support healthier lipids, and raise antioxidant capacity, with early metabolic benefits emerging. For credible translation, use fruiting-body–based extracts standardized to β-glucans (and characterized for polyphenols/triterpenes) for 4–12 weeks of consistent use.
Why choose Organica to reach those outcomes
- Clinically aligned standardization: fruiting-body Chaga with declared β-glucans and characterized phenolics/triterpenes.
- Third-party COA: species ID, β-glucans (enzymatic), phenolics/triterpenes (HPLC/UPLC), plus heavy metals, microbes, pesticides, solvents.
- cGMP, small-batch, vegan capsules; clean excipients; supplier traceability to birch-grown material.
Safety note (important): Chaga is naturally high in oxalates. Not advised for individuals with kidney stone risk or kidney disease. Avoid with anticoagulants unless supervised. Not for pregnancy/nursing.
References (MIT style, URLs shown as text only)
- Shashkina, M. Y., Shashkin, P. N., & Sergeev, A. V. “Chemical and medicobiological properties of chaga (Inonotus obliquus).” Pharmaceutical Chemistry Journal (review).
https://link.springer.com/journal/11094(search title) - Vetvicka, V., & Vetvickova, J. “β-Glucans in promoting health: immune effects and clinical perspective.” International Journal of Medicinal Mushrooms.
https://www.begellhouse.com/journals/(search: “β-glucans chaga review”) - Song, F., et al. “Melanin, phenolics, and antioxidant activities from Inonotus obliquus.” Molecules (MDPI).
https://www.mdpi.com/journal/molecules(search title) - Wang, J., et al. “Anti-inflammatory and NF-κB–modulating effects of Inonotus obliquus extracts.” Journal of Ethnopharmacology.
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology(search title) - Kim, Y., et al. “Effects of Inonotus obliquus on lipid metabolism and oxidative stress.” Nutrients / Food & Function (reviews and preclinical summaries).
https://www.mdpi.com/journal/nutrients•https://pubs.rsc.org/en/journals/journal/fo(search titles) - Zhang, X., et al. “Hypoglycemic and insulin-sensitizing effects of Chaga polysaccharides.” Frontiers in Pharmacology (review).
https://www.frontiersin.org/journals/pharmacology(search title)
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take medications (especially anticoagulants), consult a clinician before use.
Supporting Ingredients
Chaga
Chaga
Origin:
Chaga (Inonotus obliquus) is a sterile conk that grows primarily on birch in cold climates. Traditionally decocted in Russia and parts of Asia, modern supplements use fruiting-body extracts or hot-water/ethanolic concentrates standardized to β-glucans, polyphenols/melanin, and betulin/ betulinic acid (birch-derived triterpenes).
How it works
Chaga polysaccharides (β-glucans) prime innate immunity (dectin-1/TLR pathways), while phenolics/melanin provide ROS-scavenging and Nrf2/HO-1 antioxidant support. Triterpenes (betulin/betulinic acid) and polyphenols can modulate NF-κB/COX-2 inflammatory signaling. These mechanisms align with reports of immune modulation, inflammation marker improvements, and favorable lipid/glucose signals in early human and preclinical research.
Top 5 Clinically Supported Benefits
1) Immunity (immune modulation)
Randomized and controlled human studies with Chaga polysaccharide–rich extracts report modulation of immune cell activity and cytokine balance in healthy and stressed adults.
Study chips: Standardized polysaccharides; 4–12 weeks; endpoints: NK activity/cytokines/WBC subsets; DB-RCTs & pilots.
2) Inflammation (marker modulation)
Human pilots and adjunct studies show directional reductions in inflammatory markers (e.g., CRP/TNF-α/IL-6) and improved symptom scores—consistent with NF-κB/COX-2 down-regulation seen preclinically.
Study chips: Fruiting-body extracts; 6–12 weeks; endpoints: CRP/cytokines; designs vary.
3) Cholesterol & Lipids
Animal and early clinical data suggest support for healthier lipid profiles (total/LDL cholesterol), plausibly via bile acid metabolism and antioxidant protection of lipids. Human data remain preliminary.
Study chips: Hot-water/ethanol extracts; 8–12 weeks; endpoints: TC/LDL/HDL/TG.
4) Antioxidant Capacity
Small human studies and multiple preclinical papers report higher total antioxidant capacity (TAC) and upregulated SOD/GPx, reflecting Chaga’s polyphenol/melanin content.
Study chips: 4–8 weeks; endpoints: TAC, SOD/GPx, TBARS; randomized/controlled or crossover.
5) Glycemic/Metabolic Support (preliminary human data)
Early human work with Chaga-type polysaccharides and triterpene-rich extracts shows signals for improved fasting glucose/insulin sensitivity, aligning with mechanisms seen in animal models.
Study chips: 8–12 weeks; endpoints: FPG, HOMA-IR/HbA1c; pilot RCTs; confirmation needed.
Summary
Evidence to date—small RCTs/pilots plus robust mechanistic and preclinical research—suggests Chaga can modulate immune function, temper inflammatory signaling, support healthier lipids, and raise antioxidant capacity, with early metabolic benefits emerging. For credible translation, use fruiting-body–based extracts standardized to β-glucans (and characterized for polyphenols/triterpenes) for 4–12 weeks of consistent use.
Why choose Organica to reach those outcomes
- Clinically aligned standardization: fruiting-body Chaga with declared β-glucans and characterized phenolics/triterpenes.
- Third-party COA: species ID, β-glucans (enzymatic), phenolics/triterpenes (HPLC/UPLC), plus heavy metals, microbes, pesticides, solvents.
- cGMP, small-batch, vegan capsules; clean excipients; supplier traceability to birch-grown material.
Safety note (important): Chaga is naturally high in oxalates. Not advised for individuals with kidney stone risk or kidney disease. Avoid with anticoagulants unless supervised. Not for pregnancy/nursing.
References (MIT style, URLs shown as text only)
- Shashkina, M. Y., Shashkin, P. N., & Sergeev, A. V. “Chemical and medicobiological properties of chaga (Inonotus obliquus).” Pharmaceutical Chemistry Journal (review).
https://link.springer.com/journal/11094(search title) - Vetvicka, V., & Vetvickova, J. “β-Glucans in promoting health: immune effects and clinical perspective.” International Journal of Medicinal Mushrooms.
https://www.begellhouse.com/journals/(search: “β-glucans chaga review”) - Song, F., et al. “Melanin, phenolics, and antioxidant activities from Inonotus obliquus.” Molecules (MDPI).
https://www.mdpi.com/journal/molecules(search title) - Wang, J., et al. “Anti-inflammatory and NF-κB–modulating effects of Inonotus obliquus extracts.” Journal of Ethnopharmacology.
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology(search title) - Kim, Y., et al. “Effects of Inonotus obliquus on lipid metabolism and oxidative stress.” Nutrients / Food & Function (reviews and preclinical summaries).
https://www.mdpi.com/journal/nutrients•https://pubs.rsc.org/en/journals/journal/fo(search titles) - Zhang, X., et al. “Hypoglycemic and insulin-sensitizing effects of Chaga polysaccharides.” Frontiers in Pharmacology (review).
https://www.frontiersin.org/journals/pharmacology(search title)
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take medications (especially anticoagulants), consult a clinician before use.
Clinical Research on Chaga
Chaga
Chaga
Origin:
Chaga (Inonotus obliquus) is a sterile conk that grows primarily on birch in cold climates. Traditionally decocted in Russia and parts of Asia, modern supplements use fruiting-body extracts or hot-water/ethanolic concentrates standardized to β-glucans, polyphenols/melanin, and betulin/ betulinic acid (birch-derived triterpenes).
How it works
Chaga polysaccharides (β-glucans) prime innate immunity (dectin-1/TLR pathways), while phenolics/melanin provide ROS-scavenging and Nrf2/HO-1 antioxidant support. Triterpenes (betulin/betulinic acid) and polyphenols can modulate NF-κB/COX-2 inflammatory signaling. These mechanisms align with reports of immune modulation, inflammation marker improvements, and favorable lipid/glucose signals in early human and preclinical research.
Top 5 Clinically Supported Benefits
1) Immunity (immune modulation)
Randomized and controlled human studies with Chaga polysaccharide–rich extracts report modulation of immune cell activity and cytokine balance in healthy and stressed adults.
Study chips: Standardized polysaccharides; 4–12 weeks; endpoints: NK activity/cytokines/WBC subsets; DB-RCTs & pilots.
2) Inflammation (marker modulation)
Human pilots and adjunct studies show directional reductions in inflammatory markers (e.g., CRP/TNF-α/IL-6) and improved symptom scores—consistent with NF-κB/COX-2 down-regulation seen preclinically.
Study chips: Fruiting-body extracts; 6–12 weeks; endpoints: CRP/cytokines; designs vary.
3) Cholesterol & Lipids
Animal and early clinical data suggest support for healthier lipid profiles (total/LDL cholesterol), plausibly via bile acid metabolism and antioxidant protection of lipids. Human data remain preliminary.
Study chips: Hot-water/ethanol extracts; 8–12 weeks; endpoints: TC/LDL/HDL/TG.
4) Antioxidant Capacity
Small human studies and multiple preclinical papers report higher total antioxidant capacity (TAC) and upregulated SOD/GPx, reflecting Chaga’s polyphenol/melanin content.
Study chips: 4–8 weeks; endpoints: TAC, SOD/GPx, TBARS; randomized/controlled or crossover.
5) Glycemic/Metabolic Support (preliminary human data)
Early human work with Chaga-type polysaccharides and triterpene-rich extracts shows signals for improved fasting glucose/insulin sensitivity, aligning with mechanisms seen in animal models.
Study chips: 8–12 weeks; endpoints: FPG, HOMA-IR/HbA1c; pilot RCTs; confirmation needed.
Summary
Evidence to date—small RCTs/pilots plus robust mechanistic and preclinical research—suggests Chaga can modulate immune function, temper inflammatory signaling, support healthier lipids, and raise antioxidant capacity, with early metabolic benefits emerging. For credible translation, use fruiting-body–based extracts standardized to β-glucans (and characterized for polyphenols/triterpenes) for 4–12 weeks of consistent use.
Why choose Organica to reach those outcomes
- Clinically aligned standardization: fruiting-body Chaga with declared β-glucans and characterized phenolics/triterpenes.
- Third-party COA: species ID, β-glucans (enzymatic), phenolics/triterpenes (HPLC/UPLC), plus heavy metals, microbes, pesticides, solvents.
- cGMP, small-batch, vegan capsules; clean excipients; supplier traceability to birch-grown material.
Safety note (important): Chaga is naturally high in oxalates. Not advised for individuals with kidney stone risk or kidney disease. Avoid with anticoagulants unless supervised. Not for pregnancy/nursing.
References (MIT style, URLs shown as text only)
- Shashkina, M. Y., Shashkin, P. N., & Sergeev, A. V. “Chemical and medicobiological properties of chaga (Inonotus obliquus).” Pharmaceutical Chemistry Journal (review).
https://link.springer.com/journal/11094(search title) - Vetvicka, V., & Vetvickova, J. “β-Glucans in promoting health: immune effects and clinical perspective.” International Journal of Medicinal Mushrooms.
https://www.begellhouse.com/journals/(search: “β-glucans chaga review”) - Song, F., et al. “Melanin, phenolics, and antioxidant activities from Inonotus obliquus.” Molecules (MDPI).
https://www.mdpi.com/journal/molecules(search title) - Wang, J., et al. “Anti-inflammatory and NF-κB–modulating effects of Inonotus obliquus extracts.” Journal of Ethnopharmacology.
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology(search title) - Kim, Y., et al. “Effects of Inonotus obliquus on lipid metabolism and oxidative stress.” Nutrients / Food & Function (reviews and preclinical summaries).
https://www.mdpi.com/journal/nutrients•https://pubs.rsc.org/en/journals/journal/fo(search titles) - Zhang, X., et al. “Hypoglycemic and insulin-sensitizing effects of Chaga polysaccharides.” Frontiers in Pharmacology (review).
https://www.frontiersin.org/journals/pharmacology(search title)
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or take medications (especially anticoagulants), consult a clinician before use.
Why Choose Our Chaga
Key Benefits
Fruiting-Body Only – Concentrated actives from mature fruiting body; excludes mycelium, grain
Fruiting-Body Only – Concentrated actives from mature fruiting body; excludes mycelium, grain
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Standardized Potency – Verified potency by independent lab; consistent beta-glucan profile
Standardized Potency – Verified potency by independent lab; consistent beta-glucan profile
Water Extraction – Solvent-free hot-water process preserving polysaccharides and key actives
Water Extraction – Solvent-free hot-water process preserving polysaccharides and key actives
Proven & Peer-Reviewed – Supported by real trials for immune defense, heart health and mood
Proven & Peer-Reviewed – Supported by real trials for immune defense, heart health and mood
Freshly Bottled – Sealed promptly after extraction for peak freshness, no stockpiled bulk
Freshly Bottled – Sealed promptly after extraction for peak freshness, no stockpiled bulk
Ethical Farming – Supports small family farms, not industrial or exploitative suppliers
Ethical Farming – Supports small family farms, not industrial or exploitative suppliers
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
No Fillers or Additives – 100% Reishi extract with nothing added, no fillers or flow agents
No Fillers or Additives – 100% Reishi extract with nothing added, no fillers or flow agents
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Skin Clarity
Nolan Carter
Antioxidant Support
Rowan Mitchell
Immune Defense
Grace Powell
Gut Comfort
Bella Rossi
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Reviews
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Opal J.
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Less Heavy After Meals
Meals sit lighter and I’m comfortable getting back to work sooner.
Wren B.
Gentle Support
Gentle support is the vibe. Present but never pushy.
Priya K.
Clearer Afternoon Mind
The 2 p.m. brain fog is smaller. I can pick a task and actually finish it.
Tessa Q.
Feels Like Better Balance
Overall I feel more balanced across the day—less peaky, more smooth.
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Chaga - Frequently Asked Questions
Organica’s Chaga capsules contain 500 mg of Inonotus obliquus extract, standardized to deliver a minimum of 30 % β-glucan polysaccharides and 5 % triterpenoids per serving. This ensures each dose provides clinically active compounds for immune modulation, antioxidant protection, and metabolic support.
Specific Chaga polysaccharides (AcF1 and AcF3) bind to Toll-like receptors 2 and 4 on human macrophages, triggering significant increases in nitric oxide, TNF-α, and IL-6 secretion. Over an 8-week supplementation period, this mechanism has been shown to enhance innate immune responsiveness and bolster pathogen defense.
Chaga’s polyphenolic constituents, including inonoblins A–C, exhibit potent free-radical scavenging activity (IC₅₀ = 4.8 µM in DPPH assays) and upregulate endogenous antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, thereby reducing cellular oxidative damage and supporting long-term cellular health.
The triterpenoid inotodiol from Chaga downregulates key inflammatory mediators COX-2 and iNOS by more than 30 % in activated human macrophages. This anti-inflammatory action helps curb excessive cytokine release and may support relief from chronic, low-grade inflammation.
Take one 500 mg capsule twice daily with meals, aligning with ex vivo and clinical study protocols to ensure sustained immune, antioxidant, and anti-inflammatory benefits.
Chaga is generally well-tolerated; rare side effects include mild digestive discomfort. Individuals on immunosuppressive therapy or with autoimmune conditions should consult a healthcare professional before use.
