Clarity Calm™

Origin: Holy Basil (Tulsi; Ocimum sanctum/tenuiflorum) — standardized leaf extract used for mental clarity, stress reduction/cortisol balance, focus, mood stabilization, and mental restoration, with supportive effects on inflammation/oxidative tone. We use solvent-controlled, leaf-only extracts (not essential oil).

Phytochemical Profile

• Key actives: rosmarinic acid, ursolic/oleanolic acids, ocimumosides A/B, and minor eugenol (leaf).
• Mechanisms: HPA-axis modulation (stress reactivity), gentle GABA/monoamine support, Nrf2/HO-1↑ (antioxidant) and NF-κB/COX-2↓ (inflammation) → calmer, clearer cognition.

Top 5 Clinically Supported Benefits

1) Stress & Anxiety Reduction (feelably calmer)
Randomized, placebo-controlled trials show lower perceived stress/anxiety and improved well-being with tulsi vs placebo.
Study chips: 250–500 mg/day • 4–8 weeks • Endpoints PSS, STAI, well-being scales • DB-RCTs/meta-analyses.

2) Cortisol & Physiologic Stress Markers
Controlled studies report reduced salivary cortisol and gentler HR/BP responses during acute stress tasks—consistent with HPA modulation.
Study chips: 300–500 mg/day • 4–8 weeks • Endpoints cortisol, HR/BP under stress • RCTs.

3) Cognitive Function Under Stress (clarity & focus)
Trials note better attention/processing efficiency and lower mental fatigue, supporting daytime mental clarity without stimulation.
Study chips: 250–500 mg/day • 2–8 weeks • Endpoints attention/RT, mental-fatigue scales • DB-RCTs/controlled.

4) Mood Stabilization & Sleep Quality
Participants report brighter mood, less irritability, and improved sleep quality, aiding next-day restoration.
Study chips: 250–500 mg/day • 4–8 weeks • Endpoints mood indices, PSQI • Controlled trials.

5) Inflammation & Antioxidant Capacity
Human data show TAC↑ and CRP/IL-6/TBARS↓ trends—mechanisms that underpin steady mood and cognitive comfort.
Study chips: 300–500 mg/day • 4–12 weeks • Endpoints TAC, CRP/IL-6, MDA/TBARS • Randomized/controlled.

Summary — how Holy Basil supports Clarity Calm™

• Regulates cortisol & reduces stress: Smooths the physiologic stress response for a calmer baseline.
• Focus & mental clarity: Eases mental noise and fatigue so attention feels cleaner.
• Mood stability & restoration: Supports balanced affect by day and better sleep quality at night.
• Inflammation/oxidative tone: Lowers background “noise” that drags on cognition and mood.

Why choose Organica’s Holy Basil

• Standardized leaf extract: target ≥5% rosmarinic acid (and declared triterpenes).
• Clinically aligned dose: 150 mg per serving inside Clarity Calm™ (fits 250–500 mg/day totals when stacked with other calming actives).
• Stack synergy: Complements Ashwagandha (cortisol), L-Theanine (calm-alert focus), Rhodiola (processing speed), Lemon Balm/Skullcap (GABAergic calm), Kanna (mood).
• Quality/COA: identity, rosmarinic acid/triterpenes by HPLC/UPLC; heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

References

• Nutrients — Human reviews on tulsi for stress, mood, antioxidant/inflammatory markers.
  https://www.mdpi.com/journal/nutrients
• Phytotherapy Research / Phytomedicine — RCTs/meta-analyses of tulsi on stress/anxiety, cognition under stress.
  https://onlinelibrary.wiley.com/journal/10991573 • https://www.journals.elsevier.com/phytomedicine
• Journal of Ayurveda and Integrative Medicine — Clinical trial summaries and standardization guidance for O. tenuiflorum.
  https://www.jaim.in/
• Frontiers in Pharmacology / IJMS — Mechanisms: HPA axis, monoamines, Nrf2/NF-κB signaling.
  https://www.frontiersin.org/journals/pharmacology • https://www.mdpi.com/journal/ijms
• Evidence-Based Complementary and Alternative Medicine — Controlled trials on mood/sleep/oxidative markers with tulsi.
  https://www.hindawi.com/journals/ecam/

Regulatory note: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Avoid in pregnancy/nursing. May lower blood glucose and gently thin blood; use clinician guidance with antidiabetics or anticoagulants/antiplatelets. Stop 1–2 weeks before surgery unless advised.

Origin: Lemon Balm (Melissa officinalis) — standardized leaf extract used for mental clarity, stress reduction, focus, mood stabilization, and mental restoration (sleep quality). We use solvent-controlled leaf extracts (not essential oil), typically standardized for rosmarinic acid (and related polyphenols).

Phytochemical Profile

• Rosmarinic acid, caffeic acid, luteolin/apigenin flavones; gentle terpenoids (citral/citronellal traces in leaf).
• Mechanisms: GABA-transaminase modulation (calming GABA tone), AChE/BChE inhibition (cholinergic support for attention), Nrf2/HO-1↑ & NF-κB/COX-2↓ (antioxidant/anti-inflammatory), and HPA-axis stress moderation.

Top 5 Clinically Supported Benefits

1) Stress & Anxiety Reduction
Randomized, placebo-controlled trials show lower state anxiety and perceived stress with lemon balm extracts versus placebo—often with feelable calm within hours (acute) and stronger effects over weeks.
Study chips: 300–600 mg (acute) or 200–600 mg/day • Acute to 2–8 wk • Endpoints STAI-State, PSS, VAS calmness/tension • DB-RCTs.

2) Calm-Alert Focus & Attention
Human studies report improved sustained attention/working-memory accuracy and reduced mental fatigue, reflecting combined GABA and cholinergic actions—“calm focus” without sedation.
Study chips: 300–600 mg acute; 200–300 mg/day for weeks • Endpoints RVIP, working memory, reaction time & accuracy • DB-RCTs/crossover.

3) Mood Stabilization & Well-Being
Trials note tension/irritability ↓ and contentedness ↑, supporting steadier mood across the workday.
Study chips: 200–600 mg/day • 2–8 wk • Endpoints POMS/PANAS, VAS mood • DB-RCTs.

4) Mental Restoration (Sleep Quality)
Evening or twice-daily dosing is associated with better sleep quality (latency ↓, disturbances ↓) and next-day calmness/clarity, especially in stressed adults.
Study chips: 200–600 mg/day • 4–8 wk • Endpoints PSQI, sleep diaries, morning affect • Controlled trials.

5) Physiologic Stress Markers
Controlled studies show gentler HR/BP responses during acute stress and directionally lower cortisol in some cohorts—consistent with HPA-axis modulation.
Study chips: 300–600 mg acute or 200–600 mg/day • Acute to 4–8 wk • Endpoints HR/BP under stress, salivary cortisol • Randomized/controlled.

Summary — how Lemon Balm supports Clarity Calm™

• Reduces stress & stabilizes mood: Calms the system via GABA and anti-inflammatory pathways.
• Sharpens focus without jitters: Cholinergic support + lowered mental noise improve attention and working-memory accuracy.
• Restores mentally: Eases into better sleep quality, improving next-day clarity and resilience.

Why choose Organica’s Lemon Balm

• Standardized leaf extract: target ≥5–7% rosmarinic acid with low residual solvents.
• Clinically aligned dose: 200 mg per serving in Clarity Calm™ (fits common 200–600 mg/day use).
• Stack synergy: Teams with L-theanine (calm-alert), Ashwagandha (cortisol), Rhodiola (processing speed), Tulsi/Skullcap (steady calm), and Kanna (mood).
• Third-party COA: identity, rosmarinic acid assay (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

References (URLs shown as text only)

• Phytotherapy Research — RCTs/meta-analyses of Melissa officinalis for anxiety, cognition, and sleep outcomes.
  https://onlinelibrary.wiley.com/journal/10991573
• Journal of Psychopharmacology — Acute cognition/mood trials of lemon balm preparations.
  https://journals.sagepub.com/home/jop
• Nutrients — Reviews on lemon balm polyphenols, GABA/cholinergic mechanisms, stress/sleep data.
  https://www.mdpi.com/journal/nutrients
• Evidence-Based Complementary and Alternative Medicine / Complementary Therapies in Medicine — Controlled trials on stress, sleep quality, and mood indices.
  https://www.hindawi.com/journals/ecam/ • https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
• International Journal of Molecular Sciences — Mechanistic overviews (Nrf2/NF-κB, GABA-T, AChE/BChE).
  https://www.mdpi.com/journal/ijms

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. May enhance effects of sedatives; use caution with alcohol/CNS depressants. Avoid during pregnancy. If hypothyroid and medicated, consult a clinician.

Origin: Kanna (Sceletium tortuosum) — standardized aerial-part extract used for mental clarity, stress reduction, mood stabilization, focus under pressure, and mental restoration. Modern extracts declare mesembrine-type alkaloids (mesembrine, mesembrenone, mesembrenol, mesembranol) and are typically dosed at 25–50 mg/day.

Phytochemical Profile

• Mesembrine alkaloids that modulate the serotonin transporter (SERT) → calmer affect and reduced worry.
• PDE-4 inhibition (cAMP signaling) linked to cognitive flexibility and mood support.
• fMRI human data show lower anxiety-related amygdala reactivity after acute dosing.
• Vegan; quality COAs declare total/individual mesembrine alkaloids (HPLC/UPLC).

Top 5 Clinically Supported Benefits

1) Stress & State Anxiety ↓ (feelably calmer)
Randomized, placebo-controlled human studies report reductions in state anxiety and perceived stress with standardized kanna versus placebo.
Study chips: 25–50 mg/day • 2–6 weeks (plus acute effects) • Endpoints STAI-State, PSS, mood scales • DB-RCTs.

2) Mood Stabilization & Well-Being ↑
Trials show improved positive affect and lower negative mood; participants often report less rumination and easier emotional regulation.
Study chips: 25–50 mg/day • 2–6 weeks • Endpoints PANAS/global mood • DB-RCTs.

3) Focus & Cognitive Control Under Load
Controlled studies note better executive control (e.g., response inhibition, conflict tasks) and smoother attention during stress—consistent with PDE-4 and serotonergic actions.
Study chips: single dose → 2–4 weeks • Endpoints Stroop/Go-NoGo, vigilance • DB-RCTs/crossover.

4) Anxiety-Circuit Calming (neuroimaging)
Acute fMRI work shows reduced amygdala hyper-reactivity to threat cues after kanna, aligning with subjective calm without sedation.
Study chips: single dose • Endpoints amygdala BOLD, connectivity • Placebo-controlled.

5) Sleep & Mental Restoration (adjacent signals)
Exploratory outcomes show better sleep quality and next-day calm-alertness, supporting mental restoration when used consistently.
Study chips: 25–50 mg/day • 2–6 weeks • Endpoints sleep quality scales, morning affect • Controlled.

Summary — how Kanna supports Clarity Calm™

• Regulates stress reactivity via SERT modulation and PDE-4 pathways → lower anxiety, steadier mood, and clearer focus.
• Acute + chronic utility: can take the edge off quickly, with stronger, more stable benefits over weeks—without heavy sedation.

Why choose Organica’s Kanna

• Standardized extract with declared mesembrine-type alkaloids; we use 25 mg per serving inside Clarity Calm™ (within RCT dosing).
• Clinically aligned use: once daily, AM or early afternoon; may be paired with L-theanine for smooth focus.
• Third-party COA: identity, alkaloid profile (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

References

• Neuropsychopharmacology / Human Psychopharmacology — Placebo-controlled trials and fMRI evidence for anxiety reduction & amygdala reactivity with Sceletium extracts.
  https://www.nature.com/npp/ • https://onlinelibrary.wiley.com/journal/10991077
• Phytotherapy Research / Journal of Ethnopharmacology — Clinical summaries, alkaloid chemistry, SERT/PDE-4 mechanisms.
  https://onlinelibrary.wiley.com/journal/10991573 • https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• Evidence-Based Complementary and Alternative Medicine / BMC Complementary Medicine — RCTs on mood, stress, cognition with standardized Sceletium.
  https://www.hindawi.com/journals/ecam/ • https://bmccomplementmedtherapies.biomedcentral.com/
• Frontiers in Pharmacology / International Journal of Molecular Sciences — Mechanistic reviews on SERT, PDE-4, and neurocircuit effects relevant to kanna.
  https://www.frontiersin.org/journals/pharmacology • https://www.mdpi.com/journal/ijms
• Nutrients — Overviews of botanical anxiolytics; Sceletium placement among adaptogenic/calming agents.
  https://www.mdpi.com/journal/nutrients

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Do not combine with SSRIs, SNRIs, MAOIs, or other serotonergic drugs (risk of interaction). Avoid with tramadol, MDMA, or St. John’s wort. Use caution with sedatives/alcohol. Not for pregnancy/nursing.

Origin: L-Theanine — green-tea amino acid for calm, clear focus used for mental clarity, stress reduction/cortisol balance, focus, mood stabilization, and mental restoration (sleep quality). We use bioidentical L-theanine (tea-grade) with clean excipients.

Phytochemical Profile

• Non-proteinogenic amino acid from Camellia sinensis; readily crosses the blood–brain barrier.
• Mechanisms: promotes alpha-wave EEG (relaxed alertness), moderates glutamate signaling, supports GABA tone, and gently influences dopamine/serotonin; blunts stress-induced BP/cortisol rises.
• Caffeine synergy: the classic combo (theanine + natural caffeine) improves attention/processing speed with fewer jitters.

Top 5 Clinically Supported Benefits

1) Stress Reduction & Cortisol Modulation
Randomized, placebo-controlled trials show lower state anxiety and reduced salivary cortisol during acute stress after L-theanine, with greater calm at 200–400 mg/day over weeks.
Study chips: 200–400 mg/day • Acute to 4–8 wk • Endpoints STAI-State, PSS, cortisol, HR/BP • DB-RCTs; meta-analyses.

2) Calm-Alert Focus & Attention
Theanine improves selective attention and vigilance, especially when paired with low-dose caffeine (40–100 mg)—yielding better accuracy/RT and fewer lapses without jitter.
Study chips: 100–200 mg (± caffeine) • Acute to 4 wk • Endpoints RVIP, Stroop, flanker, reaction time/accuracy • DB-RCTs.

3) Mental Clarity & Processing Under Load
Trials report faster task performance and lower mental fatigue on cognitively demanding batteries, supporting “clear thinking” during busy workdays.
Study chips: 200 mg (± caffeine) • Acute/short-course • Endpoints processing speed, dual-task performance, mental-fatigue scales • DB-RCTs.

4) Mood Stabilization (Tension/Irritability ↓)
Across controlled studies, participants report less tension and irritability and more calm contentment with daily theanine—useful alongside adaptogens for steady mood.
Study chips: 200–400 mg/day • 4–8 wk • Endpoints POMS, PANAS, VAS mood • DB-RCTs.

5) Sleep Quality & Mental Restoration
Evening or twice-daily dosing is associated with better sleep quality (less sleep latency, fewer disturbances) in stressed adults and students—without morning grogginess.
Study chips: 200–400 mg/day • 4–8 wk • Endpoints PSQI, subjective refreshment • DB-RCTs/controlled.

Summary — how L-Theanine powers Clarity Calm™

• Regulates cortisol & reduces stress: Blunts the physiologic stress response while promoting alpha-wave calm.
• Sharpens focus without jitters: Synergizes with natural caffeine for clean attention and processing speed.
• Restores mentally: Eases tension by day and improves sleep quality at night, aiding next-day clarity.

Why choose Organica’s L-Theanine

• Clinically aligned dose: 200 mg per serving in Clarity Calm™ (within common RCT ranges).
• Smart pairing: Balanced with Rhodiola (stress/velocity), Ashwagandha (cortisol), Lemon Balm/Holy Basil (calm mood), and optional green-tea caffeine in other formulas.
• Quality: Tea-grade, enantiopure L-theanine (not DL-); third-party COA for identity, purity, and contaminants.
• cGMP, vegan capsules; clean excipients.

References

• Nutrients — Systematic reviews/meta-analyses on L-theanine for stress/anxiety, sleep, and cognition; caffeine synergy.
  https://www.mdpi.com/journal/nutrients
• Journal of Functional Foods / Nutritional Neuroscience — RCTs on attention, reaction time, mood with theanine (± caffeine).
  https://www.sciencedirect.com/journal/journal-of-functional-foods • https://www.tandfonline.com/journals/ynns20
• Biological Psychology / Psychopharmacology — EEG alpha-wave studies; acute stress and attention findings.
  https://www.sciencedirect.com/journal/biological-psychology • https://link.springer.com/journal/213
• Frontiers in Nutrition / Frontiers in Neuroscience — Mechanistic overviews (glutamate/GABA, cortisol/BP, network efficiency).
  https://www.frontiersin.org/journals/nutrition • https://www.frontiersin.org/journals/neuroscience
• Sleep and Biological Rhythms / Complementary Therapies in Medicine — Human trials on sleep quality and daytime calm with theanine.
  https://onlinelibrary.wiley.com/journal/14798425 • https://www.sciencedirect.com/journal/complementary-therapies-in-medicine

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Generally well tolerated; may enhance effects of sedatives and lower stress-induced BP (monitor if on antihypertensives). Safe for daytime use; avoid combining with large caffeine doses if sensitive.

Origin: Gotu Kola (Centella asiatica) — standardized aerial-part extract used for cognitive function, memory, focus, mental velocity, neurotrophic support, and neuroprotection. Modern extracts declare triterpenes (asiaticoside, madecassoside, asiatic/madecassic acids) and are taken daily for 8–12+ weeks.

Phytochemical Profile

• Triterpenoids (asiaticoside/madecassoside; asiatic & madecassic acids) → BDNF/CREB and synaptic-plasticity signaling (preclinical; emerging human markers)
• Polyphenols & flavonoids → antioxidant (Nrf2/HO-1↑) and anti-inflammatory (NF-κB↓) support
• Microcirculation effects that may aid cerebral perfusion and task endurance
• Vegan, non-GMO; quality COAs list % total triterpenes (and/or named markers)

Top 5 Clinically Supported Benefits

1) Memory & Learning (8–12+ weeks)
Randomized and controlled trials report improvements in working and long-term memory (word-list learning, delayed recall) and global cognition in adults—most consistently in older or cognitively stressed cohorts.
Study chips: 200–600 mg/day standardized extract • 8–12+ wk • Endpoints verbal/visual memory, composite cognition • DB-RCTs/controlled; meta-analytic support.

2) Attention, Focus & Mental Velocity
Human studies note better sustained attention and faster task performance/dual-task efficiency, particularly under fatigue or stress, aligning with cholinergic and microcirculatory support.
Study chips: 200–500 mg/day • 4–12 wk • Endpoints attention batteries, reaction time, dual-task speed/accuracy • DB-RCTs/crossover.

3) Neurotrophic/Plasticity Signals (NGF/BDNF context)
Translational and early human work shows directionally increased neurotrophic markers (e.g., BDNF) with Centella triterpenes, supporting synaptic plasticity and learning consolidation.
Study chips: standardized triterpenes • 4–12 wk • Endpoints BDNF/related markers (exploratory), cognitive batteries • human pilots + robust preclinical.

4) Mood & Stress (daily resilience)
Controlled trials indicate lower anxiety/stress scores and improved well-being/sleep quality, which secondarily improves focus and task endurance.
Study chips: 250–500 mg/day • 4–8 wk • Endpoints anxiety/stress scales, sleep/well-being • DB-RCTs/controlled.

5) Neuroprotection (antioxidant & inflammation markers)
Human studies report higher total antioxidant capacity and lower lipid peroxidation with Centella, plus directionally favorable CRP/IL-6 shifts—mechanisms relevant to long-term brain health.
Study chips: 200–600 mg/day • 4–12 wk • Endpoints TAC, SOD/GPx, MDA/TBARS, CRP/IL-6 • Randomized/controlled.

Summary — how Gotu Kola supports Mind Forge™ benefits

• Cognitive function, focus & mental velocity: Improves attention and processing efficiency, particularly under stress/fatigue.
• Memory: Triterpenes support encoding/recall and neuroplasticity (BDNF/CREB pathways), complementing Bacopa/Lion’s Mane/Polygala.
• Neuroprotection: Polyphenols + triterpenes bolster antioxidant and anti-inflammatory defenses and may enhance cerebral microcirculation.

Why choose Organica’s Gotu Kola

• Standardization: ≥10–20% total triterpenes (with declared asiaticoside/madecassoside).
• Clinically aligned dosing: 200–500 mg/day for 8–12+ weeks before judging cognitive effects.
• Stack synergy: Pairs with Bacopa (memory), Lion’s Mane/Polygala (neurotrophic), Ginkgo/Sage (flow & cholinergic), L-theanine + green tea (calm-alert speed).
• Third-party COA: identity, triterpenes by HPLC/UPLC; heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

Sources

• Phytotherapy Research — RCTs/meta-analyses of Centella asiatica for cognition, mood, and neuroprotection.
  https://onlinelibrary.wiley.com/journal/10991573
• Nutrients — Human-focused reviews on Centella triterpenes, BDNF/CREB signaling, antioxidant/anti-inflammatory mechanisms.
  https://www.mdpi.com/journal/nutrients
• Journal of Ethnopharmacology / Phytomedicine — Clinical summaries, standardization guidance, and safety profiles.
  https://www.sciencedirect.com/journal/journal-of-ethnopharmacology • https://www.journals.elsevier.com/phytomedicine
• Frontiers in Pharmacology / Frontiers in Aging Neuroscience — Mechanistic overviews: triterpenes, microcirculation, neurotrophic effects.
  https://www.frontiersin.org/journals/pharmacology • https://www.frontiersin.org/journals/aging-neuroscience
• Antioxidants / IJMS — Human trials and translational data on antioxidant capacity, inflammation markers, and synaptic signaling with Centella.
  https://www.mdpi.com/journal/antioxidants • https://www.mdpi.com/journal/ijms

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Cautions: may be mildly sedating for some; take with food and avoid first use right before demanding tasks. Use caution with hepatotoxic medications or significant liver disease (rare idiosyncratic reports). Avoid in pregnancy/nursing unless advised.

Origin: Rhodiola (Rhodiola rosea) — standardized root extract used for cognitive function, focus, mental velocity (processing speed), stress resilience, mood, and neuroprotection. Modern products use 3% rosavins / 1% salidroside (or equivalent) at ~200–400 mg/day, with acute effects and stronger signals over 2–8 weeks.

Phytochemical Profile

• Rosavins (rosavin, rosarin, rosin) and salidroside: adaptogenic phenylpropanoids/phenylethanoids
• Mechanisms: HPA-axis modulation (cortisol balance), monoamine support (5-HT/DA/NE), mitochondrial & antioxidant defenses (Nrf2↑ / NF-κB↓), and neurotrophic/plasticity signals (preclinical BDNF/CREB)

Top 5 Clinically Supported Benefits

1) Mental Fatigue & Cognitive Performance Under Stress
Randomized, placebo-controlled trials show faster reaction times, better attention/accuracy, and lower mental fatigue during prolonged cognitive tasks or high-stress periods with standardized rhodiola.
Study chips: 200–400 mg/day (3%/1%) • 2–8 wk (plus acute effects within hours) • Endpoints reaction time, accuracy, sustained attention, mental fatigue scales • DB-RCTs; meta-analyses.

2) Focus & Processing Speed (Mental Velocity)
Acute and short-course studies report quicker information processing and improved working-memory efficiency, especially when tasks are demanding or time-pressured.
Study chips: single dose to 2–4 wk • Endpoints processing speed, working-memory tasks, dual-task performance • DB-RCTs/crossover.

3) Mood & Stress (Resilience)
Across RCTs in stress-related fatigue, rhodiola reduces perceived stress/anxiety and improves overall well-being, supporting clearer focus and consistent daily performance.
Study chips: 200–400 mg/day • 2–8 wk • Endpoints PSS, anxiety/depression scales, global well-being • DB-RCTs; pooled analyses.

4) Daily Energy & Burnout Symptoms
Trials in occupational stress/burnout show improved energy, concentration, and motivation relative to placebo, aligning with rhodiola’s mitochondrial and HPA-axis actions.
Study chips: 400 mg/day • 4–12 wk • Endpoints fatigue/burnout inventories, work performance measures • Randomized/controlled.

5) Neuroprotection & Antioxidant/Inflammation Markers
Human studies note directionally favorable changes in oxidative-stress and inflammation markers (e.g., TAC↑, CRP/IL-6↓ in at-risk cohorts), consistent with rhodiola’s antioxidant and anti-inflammatory mechanisms.
Study chips: 200–400 mg/day • 4–8 wk • Endpoints TAC, MDA/TBARS, CRP/IL-6 • Randomized/controlled.

Summary — how Rhodiola supports Mind Forge™ benefits

• Cognitive function, focus & mental velocity: Quickly sharpens attention and processing speed under load while reducing mental fatigue.
• Memory (indirect): By improving attention/working-memory efficiency and stress control, rhodiola supports better encoding/recall alongside core memory actives (e.g., Bacopa, Lion’s Mane).
• Neuroprotection: Antioxidant/anti-inflammatory and mitochondrial actions help preserve brain resilience; preclinical work suggests neurotrophic support.

Why choose Organica’s Rhodiola

• Standardization: 3% rosavins / 1% salidroside (or analytically equivalent).
• Dosing: 200–400 mg/day; for “feelable” focus, start with 200 mg AM (± another 100–200 mg early afternoon).
• Stack synergy: Pairs with L-theanine + natural caffeine (smooth alertness), Ginkgo (cerebral flow), Bacopa (memory), Lion’s Mane (neurotrophic).
• Third-party COA: identity (species/authenticity), rosavins/salidroside by HPLC/UPLC; heavy metals, microbes, pesticides, solvents.

Sources

• Phytomedicine / Phytotherapy Research — RCTs & meta-analyses on rhodiola for mental fatigue, stress, mood, cognitive performance.
  https://www.journals.elsevier.com/phytomedicine • https://onlinelibrary.wiley.com/journal/10991573
• Nutrients — Human-focused reviews on adaptogens, HPA-axis, cognition under stress; rhodiola clinical updates.
  https://www.mdpi.com/journal/nutrients
• BMC Complementary Medicine and Therapies — Randomized trials in occupational stress/burnout and acute cognition endpoints.
  https://bmccomplementmedtherapies.biomedcentral.com/
• Frontiers in Pharmacology / IJMS — Mechanistic reviews: monoamines, mitochondrial/antioxidant, neurotrophic (BDNF/CREB) pathways.
  https://www.frontiersin.org/journals/pharmacology • https://www.mdpi.com/journal/ijms
• Journal of Ethnopharmacology / Evidence-Based CAM — Standardization/dosing guidance and clinical summaries.
  https://www.sciencedirect.com/journal/journal-of-ethnopharmacology • https://www.hindawi.com/journals/ecam/

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Use earlier in the day (may be activating). Avoid with bipolar disorder or if highly sensitive to stimulants. Consult a clinician if pregnant/nursing or using SSRIs/MAOIs, stimulants, or anticoagulants.

Origin: A small evergreen shrub native to India and long used in Ayurveda as a rasāyana. Modern research uses standardized root extracts (withanolide-standardized).

How it works

Withanolides appear to:

• Modulate the HPA axis, reducing elevated morning cortisol.
• Support GABAergic signaling, aiding calm focus and sleep onset.
• Downshift inflammatory/oxidative pathways (e.g., NF-κB), supporting cognition and recovery.
• Support endocrine balance, with signals for testosterone under training stress and thyroid balance in subclinical cases.

Top 5 Clinically Supported Benefits

1) Stress & Anxiety ↓ (with Cortisol reduction)

A 2022 meta-analysis of randomized controlled trials (≈12 RCTs, n~1,000) shows significant reductions in stress/anxiety scores and lower morning cortisol using standardized root extract, typically 300–600 mg/day over 8–12 weeks.
Study chips: Dose 300–600 mg/day • Duration 8–12 wk • Endpoints PSS-10, HAM-A, AM serum cortisol • Design Meta-analysis + DB-RCTs.
Key evidence: Akhgarjand et al., 2022 [1].

2) Sleep Quality ↑ (efficiency & onset)

In adults with insomnia/anxiety, 300 mg twice daily for 10 weeks improved sleep efficiency, total sleep time, and sleep-onset latency (actigraphy + validated scales) vs placebo.
Study chips: Dose 300 mg BID • Duration 10 wk • Endpoints actigraphy (SE, TST, SOL), sleep scales • Design DB-RCT.
Key evidence: Langade et al., 2019 [2].
(Additional DB-RCTs at 120 mg/day for 6 weeks also show actigraphy-verified gains.)

3) Strength, Muscle Size & Recovery ↑ (with training)

Resistance-trained men taking 300 mg twice daily for 8 weeks achieved greater 1-RM strength, increases in arm/chest size, higher testosterone, lower body fat, and reduced creatine kinase vs placebo.
Study chips: Dose 300 mg BID • Duration 8 wk • Endpoints 1-RM, anthropometry, testosterone, CK • Design DB-RCT.
Key evidence: Wankhede et al., 2015 [4].

4) Cognition & Memory ↑

Adults with mild cognitive impairment taking 300 mg twice daily for 8 weeks showed significant improvements in immediate/general memory, attention, processing speed, and executive function vs placebo.
Study chips: Dose 300 mg BID • Duration 8 wk • Endpoints standardized neurocognitive battery • Design DB-RCT.
Key evidence: Choudhary et al., 2017 [3].

5) Thyroid Support (Subclinical)

In adults with subclinical hypothyroidism (elevated TSH, normal T3/T4), 300 mg twice daily for 8 weeks improved TSH and peripheral T3/T4 vs placebo. (Clinical oversight advised for any thyroid condition.)
Study chips: Dose 300 mg BID • Duration 8 wk • Endpoints TSH, T3, T4 • Design DB-RCT.
Key evidence: Sharma et al., 2018 [5].

Summary

Human double-blind, placebo-controlled trials—and a 2022 meta-analysis—indicate that standardized Ashwagandha root extract can lower stress scores and morning cortisol, improve sleep efficiency and onset (actigraphy), enhance strength and recovery with training, and support cognition and subclinical thyroid balance. Most protocols used 300–600 mg/day for 8–12 weeks with endpoints like PSS-10/HAM-A, AM cortisol, actigraphy, 1-RM, CK, TSH/T3/T4.

Why choose Organica to reach those outcomes

• Root-only, withanolide-standardized extract to mirror trial profiles
• Clinically aligned dose per serving so you can target 300–600 mg/day
• Third-party COA on every lot (identity, withanolides by HPLC/UPLC, heavy metals, microbes, pesticides, solvents)
• cGMP small-batch manufacturing; clean formula (vegan capsules, no artificial fillers)

Use consistently as directed for 8–12 weeks and pair with sleep, nutrition, and training to match clinical conditions.

References (MIT style, with links)

1. Akhgarjand, Camellia, Farzaneh Asoudeh, Amir Bagheri, et al. “Does Ashwagandha Supplementation Have a Beneficial Effect on the Management of Anxiety and Stress? A Systematic Review and Meta-analysis of Randomized Controlled Trials.” Phytotherapy Research (2022). https://doi.org/10.1002/ptr.7598
2. Langade, Deepak, Subodh Kanchi, Jaising Salve, et al. “Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.” Cureus 11, no. 9 (2019): e5797. https://doi.org/10.7759/cureus.5797 (PMCID: PMC6827862)
3. Choudhary, Dnyanraj, Sauvik Bhattacharyya, and Sekhar Bose. “Efficacy and Safety of Ashwagandha Root Extract in Improving Memory and Cognitive Functions.” Journal of Dietary Supplements 14, no. 6 (2017): 599–612. https://doi.org/10.1080/19390211.2017.1284970
4. Wankhede, Sachin, Deepak Langade, Kedar Joshi, Shymal R. Sinha, and Sauvik Bhattacharyya. “Examining the Effect of Withania somnifera Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial.” Journal of the International Society of Sports Nutrition 12 (2015): 43. https://doi.org/10.1186/s12970-015-0104-9
5. Sharma, Anju K., Indranil Basu, and Sangeeta Singh. “Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial.” Journal of Alternative and Complementary Medicine 24, no. 3 (2018): 243–248. https://doi.org/10.1089/acm.2017.0183

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If pregnant/breastfeeding or on thyroid/sedative medications, consult a clinician before use.