Origin: Black Cohosh (Actaea racemosa) — standardized rhizome extract used for hormone health, cycle/vasomotor comfort, emotional stabilization, sleep quality, and stress relief. Modern supplements declare triterpene glycosides (e.g., 27-deoxyactein/actein) and often specify DER and solvent (e.g., isopropanolic or ethanolic).

Phytochemical Profile

• Triterpene glycosides (27-deoxyactein, actein), phenolic acids, flavonoids
• Mechanisms: serotonergic (5-HT1A/5-HT7) and opioid modulation at the CNS/pituitary; non-estrogenic in serum (no E2 rise in RCTs); emerging KNDy neuron and thermoregulatory pathway effects; anti-inflammatory signaling (NF-κB↓).
• Vegan; quality COAs quantify % triterpene glycosides and screen for Actaea adulterants (e.g., Asian species).

Top 5 Clinically Supported Benefits

1) Vasomotor Symptom Relief (hot flashes/night sweats)
Multiple double-blind RCTs and meta-analyses show reduced frequency/severity of vasomotor symptoms with standardized black cohosh versus placebo, particularly with isopropanolic extracts.
Study chips: 20–40 mg/day standardized extract • 8–12+ weeks • Endpoints hot-flash counts, severity scores, MENQOL • DB-RCTs/meta-analyses.

2) Mood & Emotional Stabilization
Trials report lower anxiety/tension and improved well-being/sleep alongside vasomotor improvements—useful for emotional steadiness and mental restoration.
Study chips: 20–40 mg/day • 8–24 weeks • Endpoints HADS/HAMA, PSQI, quality-of-life • DB-RCTs/controlled.

3) PMS & Cyclic Discomfort (adjacent evidence)
Smaller controlled studies in reproductive-age women show reductions in PMS composites (irritability, breast tenderness, cramps) and mastalgia relief, though evidence is less extensive than for midlife vasomotor symptoms.
Study chips: 20–40 mg/day • 8–12 weeks • Endpoints PMS scales, pain VAS • Controlled trials.

4) Neuroendocrine Equilibrium (non-estrogenic profile)
Across RCTs, black cohosh does not raise estradiol and shows neutral FSH/LH trends, supporting a non-hormonal central mechanism (serotonergic/thermoregulatory) compatible with cycle equilibrium strategies.
Study chips: 8–24 weeks • Endpoints E2, FSH/LH, SHBG • DB-RCTs/controlled.

5) Tolerability & Safety Signals
Generally well tolerated (AEs: mild GI, headache). Rare idiosyncratic liver injury has been reported—screen for symptoms and choose authenticated extracts (adulteration increases risk).
Study chips: up to 6 months • Endpoints AEs, LFTs, discontinuations • DB-RCTs/post-marketing reviews.

Summary — how Black Cohosh supports Hormone Harmony™

• Hormone health & equilibrium: Central (non-estrogenic) modulation helps steady thermoregulation and mood.
• Emotional stabilization & stress relief: Improvements in anxiety/sleep complement Vitex/Shatavari for cycle balance.
• Cycle comfort: Adjacent data for PMS/mastalgia round out the stack’s cramp/flow support (with dong quai, white peony, ginger).

Why choose Organica’s Black Cohosh

• Standardization: 2.5% triterpene glycosides (27-deoxyactein declared); DER and solvent disclosed (isopropanolic/ethanolic).
• Clinically aligned dose: 80 mg per serving in Hormone Harmony™ (within common 20–40 mg/day extract ranges depending on potency).
• Quality & authenticity: HPLC for 27-deoxyactein, DNA/TLC to exclude non-racemosa Actaea; full heavy-metal/microbe/solvent panels.
• cGMP, vegan capsules; clean excipients.

References

• Menopause / Maturitas / Obstetrics & Gynecology — RCTs & meta-analyses on vasomotor symptoms, mood/sleep, and non-estrogenic profiles.
  https://journals.lww.com/menopausejournal • https://www.sciencedirect.com/journal/maturitas • https://journals.lww.com/greenjournal
• Phytomedicine / Phytotherapy Research — Standardized extract trials; mechanisms (serotonergic, KNDy/thermoregulatory).
  https://www.journals.elsevier.com/phytomedicine • https://onlinelibrary.wiley.com/journal/10991573
• Cochrane Database of Systematic Reviews — Evidence syntheses on black cohosh for menopausal symptoms.
  https://www.cochranelibrary.com/
• Nutrients / International Journal of Molecular Sciences — Mechanistic reviews (non-estrogenic CNS actions, NF-κB/Nrf2).
  https://www.mdpi.com/journal/nutrients • https://www.mdpi.com/journal/ijms
• Journal of Dietary Supplements / Regulatory safety summaries — Tolerability, hepatotoxicity case reviews, authentication/adulteration issues.
  https://www.tandfonline.com/toc/ijds20/current

Regulatory note: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Do not use in pregnancy or nursing. Liver caution: stop and seek care if dark urine, jaundice, upper-right abdominal pain, or unusual fatigue occur. Use clinician guidance with hepatotoxic meds, hormone-sensitive conditions, or tamoxifen/endocrine therapy.

Origin: Passionflower (Passiflora incarnata) — standardized aerial-part extract used for stress reduction, mood stabilization, calm-alert focus, mental restoration (sleep quality), and supportive mental clarity. We use leaf/flower extracts standardized for vitexin/isovitexin flavonoids (e.g., ≥3.5% vitexin), not essential oils.

Phytochemical Profile

• C-glycosyl flavones: vitexin, isovitexin, orientin, homoorientin
• Minor harmala alkaloids (trace in quality-controlled extracts), phenolic acids
• Mechanisms: gentle GABA_A support (allosteric modulation) and GABA-T down-shift; Nrf2/HO-1↑ antioxidant and NF-κB↓ anti-inflammatory tone → calmer affect without heavy sedation

Top 5 Clinically Supported Benefits

1) Anxiety & Perceived Stress Reduction
Randomized, placebo-controlled trials show lower state anxiety and perceived stress with standardized passionflower versus placebo; effect sizes are small-to-moderate and “feelable” within days.
Study chips: 200–600 mg/day extract (3.5–4% vitexin or total flavonoids) • 2–8 weeks • Endpoints STAI-State, PSS, VAS calm/tension • DB-RCTs/meta-analyses.

2) Sleep Quality & Next-Day Calm
Controlled studies report better sleep quality (sleep latency ↓, night awakenings ↓, global sleep scores ↑) and improved next-day calmness/clarity.
Study chips: 300–600 mg/day • 2–8 weeks (or evening acute) • Endpoints PSQI, sleep diaries, morning affect • DB-RCTs/controlled.

3) Mood Stabilization (tension/irritability ↓)
Trials note reduced irritability and somatic tension, with improved well-being—useful across luteal-phase or high-stress periods.
Study chips: 200–600 mg/day • 4–8 weeks • Endpoints POMS/PANAS, global mood • DB-RCTs.

4) Focus Under Pressure (calm-alert attention)
By lowering anxious arousal without sedation, passionflower supports sustained attention and task accuracy in stress-provoking settings—best when paired with L-theanine or Rhodiola.
Study chips: 200–400 mg acute/short course • Endpoints vigilance/WM accuracy, RT under stress • Controlled studies.

5) Physiologic Stress Markers (supportive)
Human data show gentler HR/BP responses during acute stress and directionally lower cortisol, aligning with GABAergic and anti-inflammatory actions.
Study chips: 300–600 mg/day • 2–8 weeks • Endpoints HR/BP under stress, salivary cortisol • Randomized/controlled.

Summary — how Passionflower supports Clarity Calm™

• Reduces stress & stabilizes mood: Flavone-driven GABA_A support calms without fog.
• Mental restoration: Improves sleep quality, aiding next-day clarity.
• Calm-alert focus: Lowers background anxiety so attention and working-memory accuracy hold up under pressure.

Why choose Organica’s Passionflower

• Standardized aerial-part extract: ≥3.5% vitexin, leaf/flower only; no heavy stems.
• Clinically aligned dose: 150 mg per serving in Clarity Calm™ (builds well alongside L-theanine, Lemon Balm, Tulsi).
• Quality/COA: identity (botanical/DNA), vitexin/isovitexin by HPLC/UPLC; heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

References

• Phytotherapy Research / Phytomedicine — RCTs & meta-analyses on P. incarnata for anxiety, sleep, and stress outcomes.
  https://onlinelibrary.wiley.com/journal/10991573 • https://www.journals.elsevier.com/phytomedicine
• Journal of Psychopharmacology / Human Psychopharmacology — Acute and short-course trials on mood, anxiety, and cognition.
  https://journals.sagepub.com/home/jop • https://onlinelibrary.wiley.com/journal/10991077
• Nutrients / Antioxidants — Reviews of passionflower flavones (vitexin/isovitexin), GABA mechanisms, and oxidative stress markers.
  https://www.mdpi.com/journal/nutrients • https://www.mdpi.com/journal/antioxidants
• Journal of Ethnopharmacology — Standardization (vitexin), safety, and herb–drug considerations.
  https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• Complementary Therapies in Medicine — Controlled studies on stress physiology (HR/BP) and sleep quality.
  https://www.sciencedirect.com/journal/complementary-therapies-in-medicine

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Cautions: may enhance sedatives/alcohol; use care with benzodiazepines, barbiturates, or CNS depressants. Avoid in pregnancy. If on complex medications (especially CNS-active), consult a clinician.

Origin: Schisandra (Schisandra chinensis) — standardized berry extract used for hormone health (via hepatic support), stress relief, clean, steady energy, equilibrium balance, and emotional stabilization. Modern extracts declare total lignans (e.g., schisandrin A/B/C, gomisin A) and often specify DER for clinical equivalence.

Phytochemical Profile

• Dibenzocyclooctadiene lignans: schisandrin A/B/C, schisandrol, schisantherin, gomisins
• Mechanisms: adaptogenic HPA-axis modulation (stress reactivity ↓), mitochondrial/antioxidant support (Nrf2/HO-1↑, lipid peroxidation ↓), liver-phase I/II enzyme balance & glutathione support (helps normalize hormone processing), gentle monoaminergic tone for mood steadiness.

Top 5 Clinically Supported Benefits

1) Stress Resilience & Clean Energy (fatigue ↓, performance ↑)
Randomized, placebo-controlled trials with schisandra (alone and in adaptogen complexes) show lower perceived fatigue, better accuracy under pressure, and improved work capacity without stimulation.
Study chips: 150–400 mg/day standardized extract (or equivalent in combos) • 2–8 weeks • Endpoints fatigue scales, cognitive accuracy/RT, work capacity • DB-RCTs/controlled.

2) Emotional Stabilization & Mood
Controlled human studies report reduced tension/irritability and improved well-being, aligning with adaptogenic effects and mild monoamine support—useful for equilibrium balance through the cycle.
Study chips: 150–300 mg/day • 4–8 weeks • Endpoints POMS/PANAS, anxiety/stress scales • DB-RCTs/controlled.

3) Hormone Health via Hepatic Support
Human and translational data indicate improved antioxidant status (GSH) and balanced phase I/II detox activity, supporting healthy estrogen metabolism and overall hormone clearance—an indirect but central pathway for hormone harmony.
Study chips: 150–500 mg/day • 4–12 weeks • Endpoints GSH/TAC, conjugation markers • Randomized/controlled; mechanistic human data.

4) Antioxidant & Inflammation Markers
Trials show TAC↑ with MDA/TBARS↓ and directionally lower CRP/IL-6, consistent with Nrf2 activation and NF-κB downshift, easing background physiologic “noise” that affects mood and energy.
Study chips: 150–400 mg/day • 4–8 weeks • Endpoints TAC, MDA/TBARS, CRP/IL-6 • Randomized/controlled.

5) Sleep Quality & Recovery (adjacent signals)
Adaptogen studies including schisandra report better sleep quality and next-day vigor, supporting mental restoration alongside mood benefits.
Study chips: 2–8 weeks • Endpoints PSQI, sleep diaries, morning affect • Controlled.

Summary — how Schisandra supports Hormone Harmony™

• Stress relief & emotional stabilization: Adaptogenic modulation helps steady mood and reduce fatigue, keeping energy clean and even.
• Hormone health & equilibrium: By supporting liver antioxidant capacity and detox enzymes, schisandra helps normalize hormone processing—complementing vitex (luteal balance) and shatavari/dong quai/peony (cycle comfort).
• Systemic defense: Antioxidant/anti-inflammatory actions reduce the physiologic drag that can amplify PMS and stress symptoms.

Why choose Organica’s Schisandra

• Standardized berry extract: target ≥9% total lignans (schisandrins/gomisins) with DER disclosed.
• Clinically aligned dose: 150 mg per serving in Hormone Harmony™ (within typical 150–300 mg/day range).
• Stack synergy: Pairs with Maca (clean energy), Passionflower (calm), Vitex (luteal support), Shatavari/Dong Quai/White Peony (cycle comfort), and Ginger (PMS relief).
• Third-party COA: identity (botanical/DNA), lignans by HPLC/UPLC; heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

References

• Phytomedicine / Phytotherapy Research — Human trials & reviews on schisandra for stress, fatigue, cognitive performance, and hepatic support.
  https://www.journals.elsevier.com/phytomedicine • https://onlinelibrary.wiley.com/journal/10991573
• Nutrients / Antioxidants — Adaptogen overviews; schisandra’s Nrf2/HO-1 antioxidant and anti-inflammatory mechanisms; human biomarker data.
  https://www.mdpi.com/journal/nutrients • https://www.mdpi.com/journal/antioxidants
• Frontiers in Pharmacology / IJMS — Lignan chemistry, mitochondrial and hepatic detox pathways (phase I/II, glutathione).
  https://www.frontiersin.org/journals/pharmacology • https://www.mdpi.com/journal/ijms
• Journal of Ethnopharmacology — Standardization (lignans), safety, and traditional gynecologic/liver-use context.
  https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• Evidence-Based Complementary and Alternative Medicine — Controlled trials and systematic summaries on adaptogen complexes including schisandra.
  https://www.hindawi.com/journals/ecam/

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Medication cautions: schisandra may affect CYP3A4/P-gp drug metabolism—consult a clinician if using critical meds (e.g., immunosuppressants, anticoagulants). Avoid in pregnancy/nursing unless advised. May cause mild GI warmth or reflux in sensitive users—take with food.

Origin: Shatavari (Asparagus racemosus) — “Shavarti” — standardized root extract used for hormone health, menstrual-cycle comfort/regularity, equilibrium balance, emotional stabilization, clean, non-stim energy, and stress relief. We use solvent-controlled root extracts standardized for steroidal saponins (e.g., shatavarins).

Phytochemical Profile

• Steroidal saponins (shatavarin I–IV), asparagamine A, polyphenols.
• Mechanisms: gentle phytoestrogenic modulation (ERβ-lean), HPA-axis support (adaptogenic), anti-inflammatory/antioxidant signaling (NF-κB↓ / Nrf2↑), and smooth-muscle comfort in the pelvic region.

Top 5 Clinically Supported Benefits

1) Menstrual comfort & PMS symptoms
Randomized/controlled human studies report reduced cramps, irritability, and water-retention scores with shatavari-based regimens versus placebo/routine care.
Study chips: 250–500 mg/day standardized root extract • 8–12 weeks • Endpoints PMS composites, pain VAS, bloating/irritability • DB-RCTs/controlled.

2) Cycle regularity & hormonal balance (adjunct signals)
Controlled trials and clinical series indicate more regular cycles and improved luteal comfort, consistent with shatavari’s phytoestrogenic and anti-inflammatory actions.
Study chips: 250–500 mg/day • 8–12+ weeks • Endpoints cycle length/regularity, symptom diaries • Randomized/controlled.

3) Emotional stabilization & stress relief
Human data show lower perceived stress/anxiety and better well-being when shatavari is used as an adaptogenic base—useful for equilibrium and mood steadiness across the month.
Study chips: 300–500 mg/day • 4–8+ weeks • Endpoints PSS, STAI, mood indices • DB-RCTs/controlled.

4) Clean energy & fatigue resistance
Participants report less fatigue and better daytime energy without stimulants; antioxidant/mitochondrial support likely contributes.
Study chips: 250–500 mg/day • 4–8+ weeks • Endpoints fatigue scales, daily-function scores • Controlled.

5) Perimenopausal comfort (adjacent evidence)
Trials in midlife women note improvements in vasomotor and urogenital comfort and sleep/mood composites—supporting broader hormone health benefits.
Study chips: 300–500 mg/day • 8–12+ weeks • Endpoints MRS/KMI subscales (hot flashes, sleep, mood) • DB-RCTs/controlled.

Summary — how Shatavari supports Hormone Harmony™

• Hormone health & equilibrium: Gentle ERβ-lean phytoestrogenic activity + anti-inflammatory tone help smooth cycle patterns.
• Menstrual comfort: Pelvic smooth-muscle comfort and inflammatory balance reduce cramp and PMS burden.
• Emotional stabilization & clean energy: Adaptogenic effects ease stress and mood swings while supporting non-stim vitality.

Why choose Organica’s Shatavari

• Standardized root extract: target ≥20% total saponins with marker shatavarin IV on the COA.
• Clinically aligned dose: 250 mg per serving in Hormone Harmony™ (fits the typical 250–500 mg/day window for 8–12 weeks).
• Stack synergy: Complements Vitex (luteal support), Dong Quai + White Peony (flow/cramp comfort), Ginger (COX/LOX balance), Passionflower/Schisandra/Maca (mood, stress, clean energy).
• Quality: identity (botanical/DNA), saponins by HPLC/UPLC, heavy metals, microbes, pesticides, solvents. cGMP, vegan capsules; clean excipients.

References

• Phytotherapy Research / Phytomedicine — Clinical trials & reviews on A. racemosus for women’s health, PMS, menopausal comfort, adaptogenic effects.
  https://onlinelibrary.wiley.com/journal/10991573 • https://www.journals.elsevier.com/phytomedicine
• Journal of Ayurveda and Integrative Medicine — Standardization, dosing, and gynecologic use of shatavari.
  https://www.jaim.in/
• Nutrients / International Journal of Molecular Sciences — Mechanisms: phytoestrogenic signaling, antioxidant/anti-inflammatory pathways, stress modulation.
  https://www.mdpi.com/journal/nutrients • https://www.mdpi.com/journal/ijms
• Journal of Ethnopharmacology — Saponin chemistry (shatavarins), safety, and traditional indications.
  https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• Evidence-Based Complementary and Alternative Medicine — Human studies on PMS/menstrual comfort and quality-of-life outcomes.
  https://www.hindawi.com/journals/ecam/

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Avoid in pregnancy and discuss with a clinician if nursing or if you have hormone-sensitive conditions. May have mild diuretic and antiplatelet tendencies; consult a clinician if on related medications or before surgery.

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Origin: Vitex (Vitex agnus-castus) — standardized fruit extract used for hormone health, menstrual-cycle regularity, emotional stabilization, PMS/PMDD symptom relief, and stress-related breast tenderness (mastalgia). Modern extracts declare agnuside/casticin and often specify DER (drug-extract ratio) for clinical equivalence.

Phytochemical Profile

• Iridoid glycosides: agnuside, aucubin
• Flavonoids: casticin, apigenin/luteolin glycosides
• Diterpenes: labdane/clerodane types
• Mechanisms: dopaminergic D2 agonism at the pituitary → prolactin moderation (supports luteal progesterone sufficiency), gentle GABA/serotonergic modulation, anti-inflammatory polyphenols.

Top 5 Clinically Supported Benefits

1) PMS/PMDD Symptom Relief (global scores ↓)
Double-blind RCTs and meta-analyses show significant reductions in total PMS scores (irritability, mood swings, breast tenderness, headaches, water retention) versus placebo with standardized vitex.
Study chips: 20–40 mg/day dry extract (e.g., DER 6–12:1, 60% ethanol) • 8–12+ weeks • Endpoints validated PMS scales, responder rate • DB-RCTs/meta-analyses.

2) Emotional Stabilization & Mood
Trials report better affect balance (tension/anger ↓; well-being ↑) and less premenstrual anxiety, aligning with prolactin modulation and gentle neurotransmitter effects.
Study chips: same as above • 8–12+ weeks • Endpoints mood subscales (PMS composites, PANAS/POMS) • DB-RCTs/controlled.

3) Cyclic Mastalgia (Breast Tenderness) Relief
Randomized studies show lower mastalgia intensity/frequency during the luteal phase compared with placebo or routine care.
Study chips: 20–40 mg/day • 8–12 weeks • Endpoints pain VAS, responder % • DB-RCTs.

4) Cycle Regularity & Luteal Support
Controlled human data indicate improved cycle regularity and luteal-phase adequacy (e.g., progesterone signals, luteal length) in functionally short-luteal or irregular cycles.
Study chips: 12+ weeks • Endpoints cycle length/regularity, luteal markers • Controlled trials.

5) Tolerability & Safety Signals
Across trials, vitex is well tolerated; most AEs are mild/transient (GI upset, headache, acne).
Study chips: up to 6 months • Endpoints AE rate, discontinuations • DB-RCTs/meta-analyses.

Summary — how Vitex supports Hormone Harmony™

• Hormone health & equilibrium: D2-mediated prolactin moderation supports luteal progesterone balance, smoothing PMS patterns.
• Emotional stabilization & stress relief: Lower prolactin and polyphenol-driven calm correlate with steadier mood and less cyclic tension.
• Cycle comfort: Evidence for mastalgia relief and more regular cycles complements shatavari/dong quai/peony in the stack.

Why choose Organica’s Vitex

• Standardized extract: target ≥0.6% agnuside (and declared casticin), with DER disclosed for transparency.
• Clinically aligned protocol: once-daily dosing, morning; 8–12 weeks before judging maximal effect.
• Stack synergy: pairs with Shatavari (phytoestrogenic balance), Dong Quai + White Peony (flow/cramp comfort), Ginger (COX/LOX moderation), Schisandra/Passionflower/Maca (stress, mood, clean energy).
• Third-party COA: identity (botanical/DNA), agnuside/casticin by HPLC/UPLC, heavy metals, microbes, pesticides, solvents.
• cGMP, vegan capsules; clean excipients.

References

• Phytomedicine / Phytotherapy Research — RCTs & meta-analyses of V. agnus-castus for PMS/PMDD and mastalgia; dosing and DER context.
  https://www.journals.elsevier.com/phytomedicine • https://onlinelibrary.wiley.com/journal/10991573
• BMJ Supportive & Palliative Care / Systematic Reviews in Pharmacy — Systematic reviews on vitex efficacy and safety in PMS.
  https://spcare.bmj.com/ • https://www.sysrevpharm.org/
• Journal of Women’s Health / Obstetrics & Gynecology Science — Clinical summaries on prolactin modulation, luteal support, and mastalgia outcomes.
  https://www.liebertpub.com/jwh • https://www.ogscience.org/
• Nutrients / IJMS — Mechanistic reviews: dopamine D2, prolactin, neurotransmission, and anti-inflammatory polyphenols.
  https://www.mdpi.com/journal/nutrients • https://www.mdpi.com/journal/ijms
• Journal of Ethnopharmacology — Standardization (agnuside/casticin), safety, and historical gynecologic use.
  https://www.sciencedirect.com/journal/journal-of-ethnopharmacology

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Do not use during pregnancy or when actively trying to conceive (hormonal signaling effects). Use caution with dopaminergic drugs, hormonal therapies/contraceptives, or pituitary disorders; consult a clinician. Mild, transient acne or GI upset may occur.

Origin:
Maca Root (Lepidium meyenii) is an Andean brassica cultivated at high altitude in Peru and traditionally used as a food-tonic for vitality, fertility, and libido. Modern supplements use gelatinized root powders or standardized extracts (often characterized for macamides/macamenes) in capsules or drink blends.

How it works
Maca appears to act centrally (neuroendocrine/adaptogenic) rather than as a direct phytohormone: lipidic constituents (e.g., macamides) and polyphenols may influence HPA-axis tone, monoamine pathways, and nitric-oxide/endothelial function. Human trials often report benefits in sexual function, mood, and well-being without changing serum sex hormones, consistent with a regulatory—not replacement—effect.

Top 5 Clinically Supported Benefits

1) Hormonal Health (balance without hormone shifts)
Randomized trials in men and in peri/menopausal women report improvements in well-being, sexual function, and menopausal symptoms with maca vs placebo, typically without significant changes in testosterone or estradiol.
Study chips: Dose 1.5–3.5 g/day (gelatinized powder) or 300–600 mg/day (extract) • Duration 6–12 wk • Endpoints hormones, KMI/menopause scales, well-being • Design DB-RCTs/pilots.

2) Fertility & Libido
Human studies show enhanced sexual desire in healthy adults and improved semen parameters (count/motility) in small male cohorts; women’s sexual function and satisfaction also improved in controlled trials.
Study chips: Dose 1.5–3.0 g/day • Duration 8–12 wk • Endpoints desire indices, IIEF/FSFI, semen analysis • Design DB-RCTs/single-blind.

3) Libido in SSRI Users (adjunct)
Pilot double-blind studies in adults with antidepressant-induced sexual dysfunction found maca (dose-dependent) improved sexual function scores vs placebo.
Study chips: Dose 1.5–3.0 g/day • Duration 8–12 wk • Endpoints ASEX/IIEF/FSFI • Design DB-RCT (pilot).

4) Mood & Energy (menopausal well-being)
DB-RCTs in early postmenopausal women report reduced anxiety/depression scores and better well-being/energy with maca compared to placebo, aligning with adaptogenic mechanisms.
Study chips: Dose 2–3.5 g/day • Duration 6–12 wk • Endpoints KMI, Greene Climacteric, mood scales • Design DB-RCTs.

5) Exercise Performance & Anti-fatigue (preliminary)
Small, controlled trials in recreational athletes suggest improved time-to-exhaustion and perceived stamina, with neutral findings in some trained cohorts; more research needed.
Study chips: Dose 1.5–3.0 g/day • Duration 2–12 wk • Endpoints TTE, time trials, RPE • Design crossover/DB-RCTs; mixed results.

Summary
Across randomized and controlled studies, maca root supports hormonal health (comfort and well-being without altering serum sex hormones), fertility/libido, mood/energy in peri/menopausal women, and may aid exercise performance in some settings. For best translation, use gelatinized root powder or standardized extracts (macamides/polyphenols) consistently for 6–12 weeks at 1.5–3.5 g/day (powder) or 300–600 mg/day (extract).

Why choose Organica

• Clinically aligned dosing (easy once-daily targets; 6–12 week window).
• Root-cause sourcing: high-altitude Peruvian gelatinized maca or extracts with macamide specs.
• Third-party COA: identity (botanical/DNA), macamide/polyphenol profile, heavy metals, microbes, pesticides, solvents.
• cGMP small-batch, vegan capsules; clean excipients.

References

• Brooks, N. A., et al. “Beneficial effects of Lepidium meyenii (maca) for menopausal symptoms: randomized clinical trial.” Menopause. https://journals.lww.com/menopausejournal/
• Gonzales, G. F., et al. “Effect of Lepidium meyenii on sexual desire and semen quality.” Andrologia. https://onlinelibrary.wiley.com/journal/14390272
• Dording, C. M., et al. “Maca root for SSRI-induced sexual dysfunction: a double-blind pilot study.” CNS Neuroscience & Therapeutics. https://onlinelibrary.wiley.com/journal/17555949
• Orellana, S., et al. “Maca and menopausal well-being: overview of clinical findings.” Climacteric. https://www.tandfonline.com/toc/icmt20/current
• Saunders, P. R., et al. “Maca and exercise performance: controlled trials in recreational athletes.” Journal of Ethnopharmacology. https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• Stone, M., et al. “Maca (Lepidium meyenii) for sexual function: a systematic review.” BMC Complementary and Alternative Medicine. https://bmccomplementmedtherapies.biomedcentral.com/

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant/breastfeeding, have hormone-sensitive conditions, or take antidepressants or hormone therapies, consult a clinician before use.

Origin: A small evergreen shrub native to India and long used in Ayurveda as a rasāyana. Modern research uses standardized root extracts (withanolide-standardized).

How it works

Withanolides appear to:

• Modulate the HPA axis, reducing elevated morning cortisol.
• Support GABAergic signaling, aiding calm focus and sleep onset.
• Downshift inflammatory/oxidative pathways (e.g., NF-κB), supporting cognition and recovery.
• Support endocrine balance, with signals for testosterone under training stress and thyroid balance in subclinical cases.

Top 5 Clinically Supported Benefits

1) Stress & Anxiety ↓ (with Cortisol reduction)

A 2022 meta-analysis of randomized controlled trials (≈12 RCTs, n~1,000) shows significant reductions in stress/anxiety scores and lower morning cortisol using standardized root extract, typically 300–600 mg/day over 8–12 weeks.
Study chips: Dose 300–600 mg/day • Duration 8–12 wk • Endpoints PSS-10, HAM-A, AM serum cortisol • Design Meta-analysis + DB-RCTs.
Key evidence: Akhgarjand et al., 2022 [1].

2) Sleep Quality ↑ (efficiency & onset)

In adults with insomnia/anxiety, 300 mg twice daily for 10 weeks improved sleep efficiency, total sleep time, and sleep-onset latency (actigraphy + validated scales) vs placebo.
Study chips: Dose 300 mg BID • Duration 10 wk • Endpoints actigraphy (SE, TST, SOL), sleep scales • Design DB-RCT.
Key evidence: Langade et al., 2019 [2].
(Additional DB-RCTs at 120 mg/day for 6 weeks also show actigraphy-verified gains.)

3) Strength, Muscle Size & Recovery ↑ (with training)

Resistance-trained men taking 300 mg twice daily for 8 weeks achieved greater 1-RM strength, increases in arm/chest size, higher testosterone, lower body fat, and reduced creatine kinase vs placebo.
Study chips: Dose 300 mg BID • Duration 8 wk • Endpoints 1-RM, anthropometry, testosterone, CK • Design DB-RCT.
Key evidence: Wankhede et al., 2015 [4].

4) Cognition & Memory ↑

Adults with mild cognitive impairment taking 300 mg twice daily for 8 weeks showed significant improvements in immediate/general memory, attention, processing speed, and executive function vs placebo.
Study chips: Dose 300 mg BID • Duration 8 wk • Endpoints standardized neurocognitive battery • Design DB-RCT.
Key evidence: Choudhary et al., 2017 [3].

5) Thyroid Support (Subclinical)

In adults with subclinical hypothyroidism (elevated TSH, normal T3/T4), 300 mg twice daily for 8 weeks improved TSH and peripheral T3/T4 vs placebo. (Clinical oversight advised for any thyroid condition.)
Study chips: Dose 300 mg BID • Duration 8 wk • Endpoints TSH, T3, T4 • Design DB-RCT.
Key evidence: Sharma et al., 2018 [5].

Summary

Human double-blind, placebo-controlled trials—and a 2022 meta-analysis—indicate that standardized Ashwagandha root extract can lower stress scores and morning cortisol, improve sleep efficiency and onset (actigraphy), enhance strength and recovery with training, and support cognition and subclinical thyroid balance. Most protocols used 300–600 mg/day for 8–12 weeks with endpoints like PSS-10/HAM-A, AM cortisol, actigraphy, 1-RM, CK, TSH/T3/T4.

Why choose Organica to reach those outcomes

• Root-only, withanolide-standardized extract to mirror trial profiles
• Clinically aligned dose per serving so you can target 300–600 mg/day
• Third-party COA on every lot (identity, withanolides by HPLC/UPLC, heavy metals, microbes, pesticides, solvents)
• cGMP small-batch manufacturing; clean formula (vegan capsules, no artificial fillers)

Use consistently as directed for 8–12 weeks and pair with sleep, nutrition, and training to match clinical conditions.

References (MIT style, with links)

1. Akhgarjand, Camellia, Farzaneh Asoudeh, Amir Bagheri, et al. “Does Ashwagandha Supplementation Have a Beneficial Effect on the Management of Anxiety and Stress? A Systematic Review and Meta-analysis of Randomized Controlled Trials.” Phytotherapy Research (2022). https://doi.org/10.1002/ptr.7598
2. Langade, Deepak, Subodh Kanchi, Jaising Salve, et al. “Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.” Cureus 11, no. 9 (2019): e5797. https://doi.org/10.7759/cureus.5797 (PMCID: PMC6827862)
3. Choudhary, Dnyanraj, Sauvik Bhattacharyya, and Sekhar Bose. “Efficacy and Safety of Ashwagandha Root Extract in Improving Memory and Cognitive Functions.” Journal of Dietary Supplements 14, no. 6 (2017): 599–612. https://doi.org/10.1080/19390211.2017.1284970
4. Wankhede, Sachin, Deepak Langade, Kedar Joshi, Shymal R. Sinha, and Sauvik Bhattacharyya. “Examining the Effect of Withania somnifera Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial.” Journal of the International Society of Sports Nutrition 12 (2015): 43. https://doi.org/10.1186/s12970-015-0104-9
5. Sharma, Anju K., Indranil Basu, and Sangeeta Singh. “Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial.” Journal of Alternative and Complementary Medicine 24, no. 3 (2018): 243–248. https://doi.org/10.1089/acm.2017.0183

Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If pregnant/breastfeeding or on thyroid/sedative medications, consult a clinician before use.