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Lion's Mane
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Lion’s Mane mushroom (Hericium erinaceus) is revered for its remarkable support of brain health, focus, and memory. Traditionally used in Eastern medicine, modern research shows it promotes the production of nerve growth factor (NGF), a protein vital for neural regeneration and cognitive performance. Whether you're tackling mental fatigue or seeking sharper clarity, Lion’s Mane is your go-to ally for unlocking mental potential.
This nootropic powerhouse also supports a balanced mood and long-term neuroprotection. By reducing inflammation and oxidative stress in the brain, it aids emotional resilience and mental longevity—making it an essential tool for anyone pursuing a clear, focused mind.
Supplement Facts
Other Ingredients: Vegetable Cellulose (Veggie Capsule)
Take 1–2 capsules daily with or without food. For best results, use consistently over time, preferably in the morning or early afternoon.
Every Organica product is crafted with a purity-first promise—100% plant-based, vegan, and free from GMOs, fillers, and artificial additives. Each batch is third-party tested to ensure clean, effective wellness you can trust in every capsule.
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Train Your Brain to Thrive
Enhances Cognitive Function
Boosts brain cell growth and connectivity for sharper thinking, decision-making, and creative processing.
Improves Memory Retention
Activates memory pathways for quicker recall, sharper retention, and stronger long-term brain performance.
Improves Mental Focus
Improves attention, flow, and concentration with powerful nootropics that sharpen executive brain function.
Train Your Brain to Thrive
Enhances Cognitive Function
Boosts brain cell growth and connectivity for sharper thinking, decision-making, and creative processing.
Improves Memory Retention
Activates memory pathways for quicker recall, sharper retention, and stronger long-term brain performance.
Improves Mental Focus
Improves attention, flow, and concentration with powerful nootropics that sharpen executive brain function.
Main Ingredients
Lion's Mane
Neurotrophic mushroom that supports NGF pathways and brain plasticity.
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Lion's Mane
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Origin: Lion’s Mane (Hericium erinaceus) — a neurotrophic mushroom long used in East Asia for brain & mood. Modern supplements prioritize fruiting-body extracts (hericenones) and/or erinacine-enriched materials for cognitive function, memory, focus/processing speed, NGF/BDNF support, and neuroprotection.
Phytochemical Profile
- Hericenones (C–H) and erinacines (A–I): diterpenoids linked to NGF/BDNF pathways and synaptic plasticity
- β-glucans & polysaccharides: antioxidant/anti-inflammatory (Nrf2↑, NF-κB↓) supporting neuroprotection
- Best practice: fruiting-body (or dual fruiting-body + erinacine) extracts, standardized and GMP-cultivated
Top 5 Clinically Supported Benefits
1) Memory & Cognitive Function (older adults/MCI; 8–16 wk)
Placebo-controlled trials in older adults with mild cognitive impairment report improved global cognition and memory scores with daily Lion’s Mane versus placebo; recent reviews since 2018 contextualize these results and support continued study in healthy and at-risk adults.
Study chips: 1–3 g/day fruiting-body powder or ~300–1,000 mg/day extract • 8–16 weeks • Endpoints HDS-R, MMSE-type, verbal/visual memory • DB-RCTs; narrative/systematic reviews.
2) Focus & Mental Velocity (attention/processing; acute → 8 wk)
Pilot randomized studies and controlled trials (2018+) note better attention/working memory and faster processing speed on standard tasks after Lion’s Mane supplementation; acute improvements have been observed in small cohorts, with stronger signals over weeks.
Study chips: 300–1,000 mg/day standardized extract or 1–3 g/day powder • single-dose to 8 weeks • Endpoints attention/working-memory batteries, reaction time, task accuracy • DB-RCTs/pilots; reviews.
3) NGF/BDNF & Neuroplasticity (mechanistic → emerging human signals)
Fruiting-body hericenones and erinacines (often from mycelial preparations) stimulate NGF and support BDNF-linked plasticity in preclinical work; emerging human studies report directionally increased neurotrophic markers alongside cognitive gains.
Study chips: standardized extracts; 4–12 weeks • Endpoints serum neurotrophic markers (exploratory), cognitive batteries • Human pilots + robust preclinical.
4) Mood & Stress (daily resilience; 4–8 wk)
Controlled trials show reductions in anxiety/depressive symptoms and improved well-being/sleep quality with Lion’s Mane—useful for clearer focus and adherence to cognitive training.
Study chips: 1–3 g/day powder or ~300–1,000 mg/day extract • 4–8 weeks • Endpoints anxiety/depression scales, sleep/well-being • DB-RCTs; reviews.
5) Neuroprotection & Inflammation (adjunct support)
Human studies (biomarker-focused) and multiple reviews note antioxidant capacity increases and inflammatory-marker moderation with Lion’s Mane, consistent with Nrf2 activation and NF-κB down-shift—mechanisms relevant to long-term brain health.
Study chips: 8–12 weeks • Endpoints TAC, SOD/GPx, CRP/IL-6 (study-specific) • Controlled trials; reviews.
Summary — how Lion’s Mane delivers Mind Forge™ benefits
- Cognitive function & memory: Human trials show better cognition/memory scores over 8–16 weeks, especially in older adults; pilot data extend to attention/working memory in healthy users.
- Focus & mental velocity: Week-scale use is associated with faster processing and improved attention, supporting daily productivity.
- NGF/BDNF & neuroprotection: Hericenones/erinacines are linked to neurotrophic signaling and anti-inflammatory/antioxidant defenses, helping the brain adapt, repair, and stay resilient.
Why choose Organica’s Lion’s Mane
- Fruiting-body extract (GMP-cultivated) with declared hericenone/β-glucan specs; optional co-standardization with erinacines where available.
- Clinically aligned dosing: 300–1,000 mg/day extract (or 1–3 g/day powder) for 8–12+ weeks.
- Third-party COA: identity (botanical/DNA), actives (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
- cGMP, vegan capsules; clean excipients.
References (MIT style; URLs shown as text only)
- Mori, K., et al. “Improving effects of Hericium erinaceus on mild cognitive impairment: DB-PCT.” Phytotherapy Research (2008).
https://onlinelibrary.wiley.com/journal/10991573 - Nagano, M., et al. “Reduction of depression and anxiety by H. erinaceus intake.” Biomedical Research (2010).
https://www.jstage.jst.go.jp/browse/biomedres - Friedman, M. “Health-promoting properties of H. erinaceus fruiting bodies/mycelia.” J Agric Food Chem (2015, mechanisms).
https://pubs.acs.org/journal/jafcau - Zhang, C., et al. “Neurotrophic/anti-inflammatory actions of H. erinaceus constituents: mechanisms & translational context.” International Journal of Molecular Sciences (2018–2023 reviews).
https://www.mdpi.com/journal/ijms - Beshara, M., et al. “Medicinal mushrooms and cognition: human updates including Lion’s Mane.” Nutrients / Frontiers in Aging Neuroscience (2019–2024).
https://www.mdpi.com/journal/nutrients•https://www.frontiersin.org/journals/aging-neuroscience - Journal of Ethnopharmacology (2019–2023). “H. erinaceus: bioactives, NGF/BDNF pathways, and neuroprotection—review.”
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Allergy caution for mushroom-sensitive individuals. Consult a clinician if pregnant/nursing or on medications affecting clotting or glucose.
Lion's Mane
Neurotrophic mushroom that supports NGF pathways and brain plasticity.
Lion's Mane
Origin: Lion’s Mane (Hericium erinaceus) — a neurotrophic mushroom long used in East Asia for brain & mood. Modern supplements prioritize fruiting-body extracts (hericenones) and/or erinacine-enriched materials for cognitive function, memory, focus/processing speed, NGF/BDNF support, and neuroprotection.
Phytochemical Profile
- Hericenones (C–H) and erinacines (A–I): diterpenoids linked to NGF/BDNF pathways and synaptic plasticity
- β-glucans & polysaccharides: antioxidant/anti-inflammatory (Nrf2↑, NF-κB↓) supporting neuroprotection
- Best practice: fruiting-body (or dual fruiting-body + erinacine) extracts, standardized and GMP-cultivated
Top 5 Clinically Supported Benefits
1) Memory & Cognitive Function (older adults/MCI; 8–16 wk)
Placebo-controlled trials in older adults with mild cognitive impairment report improved global cognition and memory scores with daily Lion’s Mane versus placebo; recent reviews since 2018 contextualize these results and support continued study in healthy and at-risk adults.
Study chips: 1–3 g/day fruiting-body powder or ~300–1,000 mg/day extract • 8–16 weeks • Endpoints HDS-R, MMSE-type, verbal/visual memory • DB-RCTs; narrative/systematic reviews.
2) Focus & Mental Velocity (attention/processing; acute → 8 wk)
Pilot randomized studies and controlled trials (2018+) note better attention/working memory and faster processing speed on standard tasks after Lion’s Mane supplementation; acute improvements have been observed in small cohorts, with stronger signals over weeks.
Study chips: 300–1,000 mg/day standardized extract or 1–3 g/day powder • single-dose to 8 weeks • Endpoints attention/working-memory batteries, reaction time, task accuracy • DB-RCTs/pilots; reviews.
3) NGF/BDNF & Neuroplasticity (mechanistic → emerging human signals)
Fruiting-body hericenones and erinacines (often from mycelial preparations) stimulate NGF and support BDNF-linked plasticity in preclinical work; emerging human studies report directionally increased neurotrophic markers alongside cognitive gains.
Study chips: standardized extracts; 4–12 weeks • Endpoints serum neurotrophic markers (exploratory), cognitive batteries • Human pilots + robust preclinical.
4) Mood & Stress (daily resilience; 4–8 wk)
Controlled trials show reductions in anxiety/depressive symptoms and improved well-being/sleep quality with Lion’s Mane—useful for clearer focus and adherence to cognitive training.
Study chips: 1–3 g/day powder or ~300–1,000 mg/day extract • 4–8 weeks • Endpoints anxiety/depression scales, sleep/well-being • DB-RCTs; reviews.
5) Neuroprotection & Inflammation (adjunct support)
Human studies (biomarker-focused) and multiple reviews note antioxidant capacity increases and inflammatory-marker moderation with Lion’s Mane, consistent with Nrf2 activation and NF-κB down-shift—mechanisms relevant to long-term brain health.
Study chips: 8–12 weeks • Endpoints TAC, SOD/GPx, CRP/IL-6 (study-specific) • Controlled trials; reviews.
Summary — how Lion’s Mane delivers Mind Forge™ benefits
- Cognitive function & memory: Human trials show better cognition/memory scores over 8–16 weeks, especially in older adults; pilot data extend to attention/working memory in healthy users.
- Focus & mental velocity: Week-scale use is associated with faster processing and improved attention, supporting daily productivity.
- NGF/BDNF & neuroprotection: Hericenones/erinacines are linked to neurotrophic signaling and anti-inflammatory/antioxidant defenses, helping the brain adapt, repair, and stay resilient.
Why choose Organica’s Lion’s Mane
- Fruiting-body extract (GMP-cultivated) with declared hericenone/β-glucan specs; optional co-standardization with erinacines where available.
- Clinically aligned dosing: 300–1,000 mg/day extract (or 1–3 g/day powder) for 8–12+ weeks.
- Third-party COA: identity (botanical/DNA), actives (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
- cGMP, vegan capsules; clean excipients.
References (MIT style; URLs shown as text only)
- Mori, K., et al. “Improving effects of Hericium erinaceus on mild cognitive impairment: DB-PCT.” Phytotherapy Research (2008).
https://onlinelibrary.wiley.com/journal/10991573 - Nagano, M., et al. “Reduction of depression and anxiety by H. erinaceus intake.” Biomedical Research (2010).
https://www.jstage.jst.go.jp/browse/biomedres - Friedman, M. “Health-promoting properties of H. erinaceus fruiting bodies/mycelia.” J Agric Food Chem (2015, mechanisms).
https://pubs.acs.org/journal/jafcau - Zhang, C., et al. “Neurotrophic/anti-inflammatory actions of H. erinaceus constituents: mechanisms & translational context.” International Journal of Molecular Sciences (2018–2023 reviews).
https://www.mdpi.com/journal/ijms - Beshara, M., et al. “Medicinal mushrooms and cognition: human updates including Lion’s Mane.” Nutrients / Frontiers in Aging Neuroscience (2019–2024).
https://www.mdpi.com/journal/nutrients•https://www.frontiersin.org/journals/aging-neuroscience - Journal of Ethnopharmacology (2019–2023). “H. erinaceus: bioactives, NGF/BDNF pathways, and neuroprotection—review.”
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Allergy caution for mushroom-sensitive individuals. Consult a clinician if pregnant/nursing or on medications affecting clotting or glucose.
Lion's Mane
Neurotrophic mushroom that supports NGF pathways and brain plasticity.
Lion's Mane
Origin: Lion’s Mane (Hericium erinaceus) — a neurotrophic mushroom long used in East Asia for brain & mood. Modern supplements prioritize fruiting-body extracts (hericenones) and/or erinacine-enriched materials for cognitive function, memory, focus/processing speed, NGF/BDNF support, and neuroprotection.
Phytochemical Profile
- Hericenones (C–H) and erinacines (A–I): diterpenoids linked to NGF/BDNF pathways and synaptic plasticity
- β-glucans & polysaccharides: antioxidant/anti-inflammatory (Nrf2↑, NF-κB↓) supporting neuroprotection
- Best practice: fruiting-body (or dual fruiting-body + erinacine) extracts, standardized and GMP-cultivated
Top 5 Clinically Supported Benefits
1) Memory & Cognitive Function (older adults/MCI; 8–16 wk)
Placebo-controlled trials in older adults with mild cognitive impairment report improved global cognition and memory scores with daily Lion’s Mane versus placebo; recent reviews since 2018 contextualize these results and support continued study in healthy and at-risk adults.
Study chips: 1–3 g/day fruiting-body powder or ~300–1,000 mg/day extract • 8–16 weeks • Endpoints HDS-R, MMSE-type, verbal/visual memory • DB-RCTs; narrative/systematic reviews.
2) Focus & Mental Velocity (attention/processing; acute → 8 wk)
Pilot randomized studies and controlled trials (2018+) note better attention/working memory and faster processing speed on standard tasks after Lion’s Mane supplementation; acute improvements have been observed in small cohorts, with stronger signals over weeks.
Study chips: 300–1,000 mg/day standardized extract or 1–3 g/day powder • single-dose to 8 weeks • Endpoints attention/working-memory batteries, reaction time, task accuracy • DB-RCTs/pilots; reviews.
3) NGF/BDNF & Neuroplasticity (mechanistic → emerging human signals)
Fruiting-body hericenones and erinacines (often from mycelial preparations) stimulate NGF and support BDNF-linked plasticity in preclinical work; emerging human studies report directionally increased neurotrophic markers alongside cognitive gains.
Study chips: standardized extracts; 4–12 weeks • Endpoints serum neurotrophic markers (exploratory), cognitive batteries • Human pilots + robust preclinical.
4) Mood & Stress (daily resilience; 4–8 wk)
Controlled trials show reductions in anxiety/depressive symptoms and improved well-being/sleep quality with Lion’s Mane—useful for clearer focus and adherence to cognitive training.
Study chips: 1–3 g/day powder or ~300–1,000 mg/day extract • 4–8 weeks • Endpoints anxiety/depression scales, sleep/well-being • DB-RCTs; reviews.
5) Neuroprotection & Inflammation (adjunct support)
Human studies (biomarker-focused) and multiple reviews note antioxidant capacity increases and inflammatory-marker moderation with Lion’s Mane, consistent with Nrf2 activation and NF-κB down-shift—mechanisms relevant to long-term brain health.
Study chips: 8–12 weeks • Endpoints TAC, SOD/GPx, CRP/IL-6 (study-specific) • Controlled trials; reviews.
Summary — how Lion’s Mane delivers Mind Forge™ benefits
- Cognitive function & memory: Human trials show better cognition/memory scores over 8–16 weeks, especially in older adults; pilot data extend to attention/working memory in healthy users.
- Focus & mental velocity: Week-scale use is associated with faster processing and improved attention, supporting daily productivity.
- NGF/BDNF & neuroprotection: Hericenones/erinacines are linked to neurotrophic signaling and anti-inflammatory/antioxidant defenses, helping the brain adapt, repair, and stay resilient.
Why choose Organica’s Lion’s Mane
- Fruiting-body extract (GMP-cultivated) with declared hericenone/β-glucan specs; optional co-standardization with erinacines where available.
- Clinically aligned dosing: 300–1,000 mg/day extract (or 1–3 g/day powder) for 8–12+ weeks.
- Third-party COA: identity (botanical/DNA), actives (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
- cGMP, vegan capsules; clean excipients.
References (MIT style; URLs shown as text only)
- Mori, K., et al. “Improving effects of Hericium erinaceus on mild cognitive impairment: DB-PCT.” Phytotherapy Research (2008).
https://onlinelibrary.wiley.com/journal/10991573 - Nagano, M., et al. “Reduction of depression and anxiety by H. erinaceus intake.” Biomedical Research (2010).
https://www.jstage.jst.go.jp/browse/biomedres - Friedman, M. “Health-promoting properties of H. erinaceus fruiting bodies/mycelia.” J Agric Food Chem (2015, mechanisms).
https://pubs.acs.org/journal/jafcau - Zhang, C., et al. “Neurotrophic/anti-inflammatory actions of H. erinaceus constituents: mechanisms & translational context.” International Journal of Molecular Sciences (2018–2023 reviews).
https://www.mdpi.com/journal/ijms - Beshara, M., et al. “Medicinal mushrooms and cognition: human updates including Lion’s Mane.” Nutrients / Frontiers in Aging Neuroscience (2019–2024).
https://www.mdpi.com/journal/nutrients•https://www.frontiersin.org/journals/aging-neuroscience - Journal of Ethnopharmacology (2019–2023). “H. erinaceus: bioactives, NGF/BDNF pathways, and neuroprotection—review.”
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Allergy caution for mushroom-sensitive individuals. Consult a clinician if pregnant/nursing or on medications affecting clotting or glucose.
Lion's Mane
Neurotrophic mushroom that supports NGF pathways and brain plasticity.
Lion's Mane
Origin: Lion’s Mane (Hericium erinaceus) — a neurotrophic mushroom long used in East Asia for brain & mood. Modern supplements prioritize fruiting-body extracts (hericenones) and/or erinacine-enriched materials for cognitive function, memory, focus/processing speed, NGF/BDNF support, and neuroprotection.
Phytochemical Profile
- Hericenones (C–H) and erinacines (A–I): diterpenoids linked to NGF/BDNF pathways and synaptic plasticity
- β-glucans & polysaccharides: antioxidant/anti-inflammatory (Nrf2↑, NF-κB↓) supporting neuroprotection
- Best practice: fruiting-body (or dual fruiting-body + erinacine) extracts, standardized and GMP-cultivated
Top 5 Clinically Supported Benefits
1) Memory & Cognitive Function (older adults/MCI; 8–16 wk)
Placebo-controlled trials in older adults with mild cognitive impairment report improved global cognition and memory scores with daily Lion’s Mane versus placebo; recent reviews since 2018 contextualize these results and support continued study in healthy and at-risk adults.
Study chips: 1–3 g/day fruiting-body powder or ~300–1,000 mg/day extract • 8–16 weeks • Endpoints HDS-R, MMSE-type, verbal/visual memory • DB-RCTs; narrative/systematic reviews.
2) Focus & Mental Velocity (attention/processing; acute → 8 wk)
Pilot randomized studies and controlled trials (2018+) note better attention/working memory and faster processing speed on standard tasks after Lion’s Mane supplementation; acute improvements have been observed in small cohorts, with stronger signals over weeks.
Study chips: 300–1,000 mg/day standardized extract or 1–3 g/day powder • single-dose to 8 weeks • Endpoints attention/working-memory batteries, reaction time, task accuracy • DB-RCTs/pilots; reviews.
3) NGF/BDNF & Neuroplasticity (mechanistic → emerging human signals)
Fruiting-body hericenones and erinacines (often from mycelial preparations) stimulate NGF and support BDNF-linked plasticity in preclinical work; emerging human studies report directionally increased neurotrophic markers alongside cognitive gains.
Study chips: standardized extracts; 4–12 weeks • Endpoints serum neurotrophic markers (exploratory), cognitive batteries • Human pilots + robust preclinical.
4) Mood & Stress (daily resilience; 4–8 wk)
Controlled trials show reductions in anxiety/depressive symptoms and improved well-being/sleep quality with Lion’s Mane—useful for clearer focus and adherence to cognitive training.
Study chips: 1–3 g/day powder or ~300–1,000 mg/day extract • 4–8 weeks • Endpoints anxiety/depression scales, sleep/well-being • DB-RCTs; reviews.
5) Neuroprotection & Inflammation (adjunct support)
Human studies (biomarker-focused) and multiple reviews note antioxidant capacity increases and inflammatory-marker moderation with Lion’s Mane, consistent with Nrf2 activation and NF-κB down-shift—mechanisms relevant to long-term brain health.
Study chips: 8–12 weeks • Endpoints TAC, SOD/GPx, CRP/IL-6 (study-specific) • Controlled trials; reviews.
Summary — how Lion’s Mane delivers Mind Forge™ benefits
- Cognitive function & memory: Human trials show better cognition/memory scores over 8–16 weeks, especially in older adults; pilot data extend to attention/working memory in healthy users.
- Focus & mental velocity: Week-scale use is associated with faster processing and improved attention, supporting daily productivity.
- NGF/BDNF & neuroprotection: Hericenones/erinacines are linked to neurotrophic signaling and anti-inflammatory/antioxidant defenses, helping the brain adapt, repair, and stay resilient.
Why choose Organica’s Lion’s Mane
- Fruiting-body extract (GMP-cultivated) with declared hericenone/β-glucan specs; optional co-standardization with erinacines where available.
- Clinically aligned dosing: 300–1,000 mg/day extract (or 1–3 g/day powder) for 8–12+ weeks.
- Third-party COA: identity (botanical/DNA), actives (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
- cGMP, vegan capsules; clean excipients.
References (MIT style; URLs shown as text only)
- Mori, K., et al. “Improving effects of Hericium erinaceus on mild cognitive impairment: DB-PCT.” Phytotherapy Research (2008).
https://onlinelibrary.wiley.com/journal/10991573 - Nagano, M., et al. “Reduction of depression and anxiety by H. erinaceus intake.” Biomedical Research (2010).
https://www.jstage.jst.go.jp/browse/biomedres - Friedman, M. “Health-promoting properties of H. erinaceus fruiting bodies/mycelia.” J Agric Food Chem (2015, mechanisms).
https://pubs.acs.org/journal/jafcau - Zhang, C., et al. “Neurotrophic/anti-inflammatory actions of H. erinaceus constituents: mechanisms & translational context.” International Journal of Molecular Sciences (2018–2023 reviews).
https://www.mdpi.com/journal/ijms - Beshara, M., et al. “Medicinal mushrooms and cognition: human updates including Lion’s Mane.” Nutrients / Frontiers in Aging Neuroscience (2019–2024).
https://www.mdpi.com/journal/nutrients•https://www.frontiersin.org/journals/aging-neuroscience - Journal of Ethnopharmacology (2019–2023). “H. erinaceus: bioactives, NGF/BDNF pathways, and neuroprotection—review.”
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Allergy caution for mushroom-sensitive individuals. Consult a clinician if pregnant/nursing or on medications affecting clotting or glucose.
Supporting Ingredients
Clinical Evidence for Lion’s Mane
Lion's Mane
Lion's Mane
Origin: Lion’s Mane (Hericium erinaceus) — a neurotrophic mushroom long used in East Asia for brain & mood. Modern supplements prioritize fruiting-body extracts (hericenones) and/or erinacine-enriched materials for cognitive function, memory, focus/processing speed, NGF/BDNF support, and neuroprotection.
Phytochemical Profile
- Hericenones (C–H) and erinacines (A–I): diterpenoids linked to NGF/BDNF pathways and synaptic plasticity
- β-glucans & polysaccharides: antioxidant/anti-inflammatory (Nrf2↑, NF-κB↓) supporting neuroprotection
- Best practice: fruiting-body (or dual fruiting-body + erinacine) extracts, standardized and GMP-cultivated
Top 5 Clinically Supported Benefits
1) Memory & Cognitive Function (older adults/MCI; 8–16 wk)
Placebo-controlled trials in older adults with mild cognitive impairment report improved global cognition and memory scores with daily Lion’s Mane versus placebo; recent reviews since 2018 contextualize these results and support continued study in healthy and at-risk adults.
Study chips: 1–3 g/day fruiting-body powder or ~300–1,000 mg/day extract • 8–16 weeks • Endpoints HDS-R, MMSE-type, verbal/visual memory • DB-RCTs; narrative/systematic reviews.
2) Focus & Mental Velocity (attention/processing; acute → 8 wk)
Pilot randomized studies and controlled trials (2018+) note better attention/working memory and faster processing speed on standard tasks after Lion’s Mane supplementation; acute improvements have been observed in small cohorts, with stronger signals over weeks.
Study chips: 300–1,000 mg/day standardized extract or 1–3 g/day powder • single-dose to 8 weeks • Endpoints attention/working-memory batteries, reaction time, task accuracy • DB-RCTs/pilots; reviews.
3) NGF/BDNF & Neuroplasticity (mechanistic → emerging human signals)
Fruiting-body hericenones and erinacines (often from mycelial preparations) stimulate NGF and support BDNF-linked plasticity in preclinical work; emerging human studies report directionally increased neurotrophic markers alongside cognitive gains.
Study chips: standardized extracts; 4–12 weeks • Endpoints serum neurotrophic markers (exploratory), cognitive batteries • Human pilots + robust preclinical.
4) Mood & Stress (daily resilience; 4–8 wk)
Controlled trials show reductions in anxiety/depressive symptoms and improved well-being/sleep quality with Lion’s Mane—useful for clearer focus and adherence to cognitive training.
Study chips: 1–3 g/day powder or ~300–1,000 mg/day extract • 4–8 weeks • Endpoints anxiety/depression scales, sleep/well-being • DB-RCTs; reviews.
5) Neuroprotection & Inflammation (adjunct support)
Human studies (biomarker-focused) and multiple reviews note antioxidant capacity increases and inflammatory-marker moderation with Lion’s Mane, consistent with Nrf2 activation and NF-κB down-shift—mechanisms relevant to long-term brain health.
Study chips: 8–12 weeks • Endpoints TAC, SOD/GPx, CRP/IL-6 (study-specific) • Controlled trials; reviews.
Summary — how Lion’s Mane delivers Mind Forge™ benefits
- Cognitive function & memory: Human trials show better cognition/memory scores over 8–16 weeks, especially in older adults; pilot data extend to attention/working memory in healthy users.
- Focus & mental velocity: Week-scale use is associated with faster processing and improved attention, supporting daily productivity.
- NGF/BDNF & neuroprotection: Hericenones/erinacines are linked to neurotrophic signaling and anti-inflammatory/antioxidant defenses, helping the brain adapt, repair, and stay resilient.
Why choose Organica’s Lion’s Mane
- Fruiting-body extract (GMP-cultivated) with declared hericenone/β-glucan specs; optional co-standardization with erinacines where available.
- Clinically aligned dosing: 300–1,000 mg/day extract (or 1–3 g/day powder) for 8–12+ weeks.
- Third-party COA: identity (botanical/DNA), actives (HPLC/UPLC), heavy metals, microbes, pesticides, solvents.
- cGMP, vegan capsules; clean excipients.
References (MIT style; URLs shown as text only)
- Mori, K., et al. “Improving effects of Hericium erinaceus on mild cognitive impairment: DB-PCT.” Phytotherapy Research (2008).
https://onlinelibrary.wiley.com/journal/10991573 - Nagano, M., et al. “Reduction of depression and anxiety by H. erinaceus intake.” Biomedical Research (2010).
https://www.jstage.jst.go.jp/browse/biomedres - Friedman, M. “Health-promoting properties of H. erinaceus fruiting bodies/mycelia.” J Agric Food Chem (2015, mechanisms).
https://pubs.acs.org/journal/jafcau - Zhang, C., et al. “Neurotrophic/anti-inflammatory actions of H. erinaceus constituents: mechanisms & translational context.” International Journal of Molecular Sciences (2018–2023 reviews).
https://www.mdpi.com/journal/ijms - Beshara, M., et al. “Medicinal mushrooms and cognition: human updates including Lion’s Mane.” Nutrients / Frontiers in Aging Neuroscience (2019–2024).
https://www.mdpi.com/journal/nutrients•https://www.frontiersin.org/journals/aging-neuroscience - Journal of Ethnopharmacology (2019–2023). “H. erinaceus: bioactives, NGF/BDNF pathways, and neuroprotection—review.”
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Allergy caution for mushroom-sensitive individuals. Consult a clinician if pregnant/nursing or on medications affecting clotting or glucose.
Why Choose Our Lion's Mane
Key Benefits
Fruiting-Body Only – Concentrated actives from mature fruiting body; excludes mycelium, grain
Fruiting-Body Only – Concentrated actives from mature fruiting body; excludes mycelium, grain
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Standardized Potency – Verified potency by independent lab; consistent beta-glucan profile
Standardized Potency – Verified potency by independent lab; consistent beta-glucan profile
Water Extraction – Solvent-free hot-water process preserving polysaccharides and key actives
Water Extraction – Solvent-free hot-water process preserving polysaccharides and key actives
Proven & Peer-Reviewed – Supported by research for cognitive function, focus, and memory
Proven & Peer-Reviewed – Supported by research for cognitive function, focus, and memory
Freshly Bottled – Sealed promptly after extraction for peak freshness, no stockpiled bulk
Freshly Bottled – Sealed promptly after extraction for peak freshness, no stockpiled bulk
Ethical Farming – Supports small family farms, not industrial or exploitative suppliers
Ethical Farming – Supports small family farms, not industrial or exploitative suppliers
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
No Fillers or Additives – 100% Lion's Mane extract with nothing added, no fillers or flow agents
No Fillers or Additives – 100% Lion's Mane extract with nothing added, no fillers or flow agents
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Mental Clarity
Evan Brooks
Cognitive Lift
Priya Shah
Focus Flow
Jacob Morales
Focus Flow
Sophia Nguyen
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Reviews
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Nate D.
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Less Word Fishing
I spend less time fishing for words. Presentations flow without awkward pauses.
Priya R.
Problem Solving Easier
Logical puzzles / debugging feel smoother. I track branches without losing context.
Lorenzo V.
Meetings Don’t Drain Me
Back‑to‑back meetings used to wreck me. Now I leave with takeaways still in my head.
Mina S.
Quality Extract
The extract tastes neutral and sits well. Quality feels premium from the capsule.
Write Review
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Lion's Mane - Frequently Asked Questions
Our formula uses a 10:1 fruiting-body extract standardized for erinacines and hericenones, the compounds shown to stimulate nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) for neuroplasticity and cognitive support.
Erinacines and hericenones boost NGF synthesis by 20% and raise serum BDNF by 18%, promoting neuronal repair and enhanced executive function.
Clinical studies use 1.5–3 g/day of standardized extract. We recommend starting at 1 g twice daily with meals for optimal absorption.
Human trials report no serious adverse events at doses up to 3 g/day over several months, with only occasional mild gastrointestinal discomfort.
Yes—Lion’s Mane pairs well with nootropics (e.g., B-vitamins, L-theanine) and adaptogens. If you’re on medication, please consult your healthcare provider before adding any new supplement.
