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Cordyceps
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Cordyceps is a performance-enhancing mushroom known for boosting stamina, oxygen utilization, and cellular energy (ATP). Traditionally used by Himalayan herders to endure high-altitude fatigue, it's now a go-to for athletes and high performers seeking natural endurance support.
Cordyceps also supports immune defense, libido, and recovery by regulating adrenal function and reducing oxidative stress. Organica’s formula harnesses the power of Cordyceps militaris, cultivated for its consistent potency and adaptogenic profile.
Supplement Facts
Other Ingredients: Vegetable Cellulose (Veggie Capsule)
Take 1 capsule 30–60 minutes before physical activity, or 1–2 daily for ongoing energy support.
Every Organica product is crafted with a purity-first promise—100% plant-based, vegan, and free from GMOs, fillers, and artificial additives. Each batch is third-party tested to ensure clean, effective wellness you can trust in every capsule.
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Nature’s Engine for Inner Strength
Elevates Performance & Exercise
Enhances oxygen efficiency and ATP production to power stamina, strength, and sustained physical output daily.
Enhances Heart Health
Supports blood flow and cardiovascular strength through optimized oxygen use and long-term adaptogenic stress balance.
Enhances Skin Radiance
Revitalizes your body’s energy systems—fueling daily vitality, youthful skin glow, and whole-body resilience.
Nature’s Engine for Inner Strength
Enhances Heart Health
Supports blood flow and cardiovascular strength through optimized oxygen use and long-term adaptogenic stress balance.
Enhances Skin Radiance
Revitalizes your body’s energy systems—fueling daily vitality, youthful skin glow, and whole-body resilience.
Elevates Performance & Exercise
Enhances oxygen efficiency and ATP production to power stamina, strength, and sustained physical output daily.
Main Ingredients
Cordyceps
Organica’s Cordyceps capsules deliver a clinically validated to enhance aerobic capacity, optimize heart‐healthy lipid.
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Cordyceps
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Origin:
Cordyceps (primarily Cordyceps sinensis/Ophiocordyceps and Cordyceps militaris) is an entomopathogenic fungus long used in Traditional Chinese Medicine for vitality and endurance. Modern products use cultured fruiting bodies or standardized extracts (often β-glucans/cordycepin) in capsule, beverage, or powder forms.
How it works
Key actives—cordycepin (3′-deoxyadenosine), adenosine analogs, and polysaccharides—appear to support mitochondrial energy and endothelial NO signaling, while providing antioxidant/anti-inflammatory activity. Cordycepin derivatives have been shown to activate AMPK-Akt-eNOS and boost nitric-oxide bioavailability in vascular cells/animal models—consistent with better oxygen use and vascular tone.
Top 5 Clinically Supported Benefits
1) Endurance & aerobic performance (VO₂, time-to-exhaustion)
Double-blind RCTs report improved aerobic capacity and exercise outcomes with Cs-4/Cordyceps over 6–12 weeks in older adults and amateur endurance athletes; some trials in trained cyclists are neutral.
“Cordyceps supplementation improved aerobic performance after 12 weeks; heart rate at a fixed workload fell by week 8.” (Savioli et al., 2022 RDBPC in amateur marathoners)
“VO₂peak and ventilatory threshold improved in older adults after 12 weeks of Cs-4 vs placebo.” (Chen et al., 2010, DB-RCT)
Study chips: Dose 2–3 g/day Cs-4 or C. sinensis • Duration 6–12 wk • Endpoints VO₂max/VT, HR at submax, TTE • Design DB-RCTs; mixed results in highly trained cohorts.
2) Heart health & endothelial support
Signals include lower exercise HR at matched workload in athletes and mechanistic support for endothelial NO (eNOS) activation with cordycepin derivatives; broader reviews outline cardioprotective actions (ischemia models).
“By 8 weeks, heart rate at the same moderate intensity dropped with Cordyceps vs placebo.” (Savioli et al., 2022)
“Cordycepin derivatives increased eNOS activity via AMPK/Akt and improved endothelial function in vivo.” (IMM-H007 studies)
Study chips: Dose 2 g/day C. sinensis (athletes) • Duration 8–12 wk • Endpoints exercise HR, vascular signaling • Design DB-RCT + mechanistic preclinical; human cardio outcomes still emerging.
3) Skin radiance & photoprotection (preclinical)
Cordyceps extracts show UVB-protective and antioxidant effects in human keratinocytes/experimental models; cosmeceutical reviews highlight anti-photoaging potential. Human cosmetic trials are limited to early/exploratory work.
Study chips: Forms mycelial/fruiting-body extracts • Models keratinocyte, ex vivo/in vivo • Endpoints CPDs, oxidative-stress pathways • Design preclinical; human data needed.
4) Immune modulation (healthy adults)
A 2024 randomized, controlled clinical trial of a C. militaris functional beverage in healthy adults reported modulation of immune responses vs control, supporting an immune-balancing role in humans.
Study chips: Form C. militaris beverage (fermentation-derived) • Duration several weeks • Endpoints immune cell/marker shifts • Design RCT in healthy adults.
5) Metabolic support (glucose—preliminary human data)
A single-blind, randomized, placebo-controlled study using C. cicadae mycelium in hyperglycemic/T2D adults showed improvements in glycemic measures vs placebo, aligning with the genus’ metabolic signals (species vary).
Study chips: Dose freeze-dried mycelium (species: C. cicadae) • Duration weeks • Endpoints fasting glucose/HbA1c (study-specific) • Design randomized, placebo-controlled; confirmatory trials needed.
Summary
Human randomized trials—especially in older or recreational athletes—suggest Cordyceps can improve aerobic performance and lower exercise HR at a set workload, with immune modulation seen in healthy adults. Mechanistic and preclinical lines support endothelial NO, antioxidant, and photoprotective actions; robust human data for skin outcomes and cardiometabolic endpoints are still developing. For best translation, use standardized fruiting-body extracts (β-glucans/cordycepin) from verified species and run them consistently for 6–12 weeks in alignment with RCTs.
Why choose Organica
- Clinically aligned formats (capsules or beverage concepts) and 6–12 week protocols.
- Root-cause sourcing: fruiting-body–based C. militaris/sinensis; optional cordycepin and ≥20% β-glucans specs.
- Third-party COA (species ID by DNA/HPLC, β-glucans, cordycepin; heavy metals, microbes, pesticides, solvents).
- cGMP small-batch, vegan capsules; clean excipients.
References
- Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590.
https://files.achs.edu/course_pdfs/herb504_effect_cs_4_exercise_performance.pdf - Savioli, F. P., et al. (2022). Effects of Cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine, 34, 100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392 - Yao, L., et al. (2024). Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular diseases—Mechanisms and evidence. Journal of Ethnopharmacology.
https://www.sciencedirect.com/science/article/pii/S0378874124006202 - Jiang, S., et al. (2019). The cordycepin derivative IMM-H007 improves endothelial dysfunction by activating AMPK/Akt/eNOS. European Journal of Pharmacology.
https://www.sciencedirect.com/science/article/pii/S0014299919301475 - Ontawong, A., et al. (2024). A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific Reports, 14, 7994.
https://www.nature.com/articles/s41598-024-58742-z.pdf - Hwang, E., et al. (2011). Photoprotective potential of Cordyceps polysaccharides against UVB-induced DNA damage. British Journal of Dermatology, 164(5), 980–982.
https://academic.oup.com/bjd/article/164/5/980/6642964 - Peng, C., et al. (2019). Protective effects of cultivated Cordyceps against UVB-induced damage in human keratinocytes. Journal of Dermatological Science.
https://www.sciencedirect.com/science/article/pii/S0753332219352229 - Hsu, C.-H., et al. (2017). Clinical evaluation of blood glucose regulation with Cordyceps cicadae mycelium in hyperglycemic patients: A randomized, placebo-controlled trial. Journal of Food and Nutrition Research, 5(2).
https://pubs.sciepub.com/jfnr/5/2/10/index.html
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition, take anticoagulants, are pregnant/breastfeeding, or have mushroom allergies, consult a clinician before use.
Cordyceps
Organica’s Cordyceps capsules deliver a clinically validated to enhance aerobic capacity, optimize heart‐healthy lipid.
Cordyceps
Origin:
Cordyceps (primarily Cordyceps sinensis/Ophiocordyceps and Cordyceps militaris) is an entomopathogenic fungus long used in Traditional Chinese Medicine for vitality and endurance. Modern products use cultured fruiting bodies or standardized extracts (often β-glucans/cordycepin) in capsule, beverage, or powder forms.
How it works
Key actives—cordycepin (3′-deoxyadenosine), adenosine analogs, and polysaccharides—appear to support mitochondrial energy and endothelial NO signaling, while providing antioxidant/anti-inflammatory activity. Cordycepin derivatives have been shown to activate AMPK-Akt-eNOS and boost nitric-oxide bioavailability in vascular cells/animal models—consistent with better oxygen use and vascular tone.
Top 5 Clinically Supported Benefits
1) Endurance & aerobic performance (VO₂, time-to-exhaustion)
Double-blind RCTs report improved aerobic capacity and exercise outcomes with Cs-4/Cordyceps over 6–12 weeks in older adults and amateur endurance athletes; some trials in trained cyclists are neutral.
“Cordyceps supplementation improved aerobic performance after 12 weeks; heart rate at a fixed workload fell by week 8.” (Savioli et al., 2022 RDBPC in amateur marathoners)
“VO₂peak and ventilatory threshold improved in older adults after 12 weeks of Cs-4 vs placebo.” (Chen et al., 2010, DB-RCT)
Study chips: Dose 2–3 g/day Cs-4 or C. sinensis • Duration 6–12 wk • Endpoints VO₂max/VT, HR at submax, TTE • Design DB-RCTs; mixed results in highly trained cohorts.
2) Heart health & endothelial support
Signals include lower exercise HR at matched workload in athletes and mechanistic support for endothelial NO (eNOS) activation with cordycepin derivatives; broader reviews outline cardioprotective actions (ischemia models).
“By 8 weeks, heart rate at the same moderate intensity dropped with Cordyceps vs placebo.” (Savioli et al., 2022)
“Cordycepin derivatives increased eNOS activity via AMPK/Akt and improved endothelial function in vivo.” (IMM-H007 studies)
Study chips: Dose 2 g/day C. sinensis (athletes) • Duration 8–12 wk • Endpoints exercise HR, vascular signaling • Design DB-RCT + mechanistic preclinical; human cardio outcomes still emerging.
3) Skin radiance & photoprotection (preclinical)
Cordyceps extracts show UVB-protective and antioxidant effects in human keratinocytes/experimental models; cosmeceutical reviews highlight anti-photoaging potential. Human cosmetic trials are limited to early/exploratory work.
Study chips: Forms mycelial/fruiting-body extracts • Models keratinocyte, ex vivo/in vivo • Endpoints CPDs, oxidative-stress pathways • Design preclinical; human data needed.
4) Immune modulation (healthy adults)
A 2024 randomized, controlled clinical trial of a C. militaris functional beverage in healthy adults reported modulation of immune responses vs control, supporting an immune-balancing role in humans.
Study chips: Form C. militaris beverage (fermentation-derived) • Duration several weeks • Endpoints immune cell/marker shifts • Design RCT in healthy adults.
5) Metabolic support (glucose—preliminary human data)
A single-blind, randomized, placebo-controlled study using C. cicadae mycelium in hyperglycemic/T2D adults showed improvements in glycemic measures vs placebo, aligning with the genus’ metabolic signals (species vary).
Study chips: Dose freeze-dried mycelium (species: C. cicadae) • Duration weeks • Endpoints fasting glucose/HbA1c (study-specific) • Design randomized, placebo-controlled; confirmatory trials needed.
Summary
Human randomized trials—especially in older or recreational athletes—suggest Cordyceps can improve aerobic performance and lower exercise HR at a set workload, with immune modulation seen in healthy adults. Mechanistic and preclinical lines support endothelial NO, antioxidant, and photoprotective actions; robust human data for skin outcomes and cardiometabolic endpoints are still developing. For best translation, use standardized fruiting-body extracts (β-glucans/cordycepin) from verified species and run them consistently for 6–12 weeks in alignment with RCTs.
Why choose Organica
- Clinically aligned formats (capsules or beverage concepts) and 6–12 week protocols.
- Root-cause sourcing: fruiting-body–based C. militaris/sinensis; optional cordycepin and ≥20% β-glucans specs.
- Third-party COA (species ID by DNA/HPLC, β-glucans, cordycepin; heavy metals, microbes, pesticides, solvents).
- cGMP small-batch, vegan capsules; clean excipients.
References
- Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590.
https://files.achs.edu/course_pdfs/herb504_effect_cs_4_exercise_performance.pdf - Savioli, F. P., et al. (2022). Effects of Cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine, 34, 100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392 - Yao, L., et al. (2024). Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular diseases—Mechanisms and evidence. Journal of Ethnopharmacology.
https://www.sciencedirect.com/science/article/pii/S0378874124006202 - Jiang, S., et al. (2019). The cordycepin derivative IMM-H007 improves endothelial dysfunction by activating AMPK/Akt/eNOS. European Journal of Pharmacology.
https://www.sciencedirect.com/science/article/pii/S0014299919301475 - Ontawong, A., et al. (2024). A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific Reports, 14, 7994.
https://www.nature.com/articles/s41598-024-58742-z.pdf - Hwang, E., et al. (2011). Photoprotective potential of Cordyceps polysaccharides against UVB-induced DNA damage. British Journal of Dermatology, 164(5), 980–982.
https://academic.oup.com/bjd/article/164/5/980/6642964 - Peng, C., et al. (2019). Protective effects of cultivated Cordyceps against UVB-induced damage in human keratinocytes. Journal of Dermatological Science.
https://www.sciencedirect.com/science/article/pii/S0753332219352229 - Hsu, C.-H., et al. (2017). Clinical evaluation of blood glucose regulation with Cordyceps cicadae mycelium in hyperglycemic patients: A randomized, placebo-controlled trial. Journal of Food and Nutrition Research, 5(2).
https://pubs.sciepub.com/jfnr/5/2/10/index.html
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition, take anticoagulants, are pregnant/breastfeeding, or have mushroom allergies, consult a clinician before use.
Cordyceps
Organica’s Cordyceps capsules deliver a clinically validated to enhance aerobic capacity, optimize heart‐healthy lipid.
Cordyceps
Origin:
Cordyceps (primarily Cordyceps sinensis/Ophiocordyceps and Cordyceps militaris) is an entomopathogenic fungus long used in Traditional Chinese Medicine for vitality and endurance. Modern products use cultured fruiting bodies or standardized extracts (often β-glucans/cordycepin) in capsule, beverage, or powder forms.
How it works
Key actives—cordycepin (3′-deoxyadenosine), adenosine analogs, and polysaccharides—appear to support mitochondrial energy and endothelial NO signaling, while providing antioxidant/anti-inflammatory activity. Cordycepin derivatives have been shown to activate AMPK-Akt-eNOS and boost nitric-oxide bioavailability in vascular cells/animal models—consistent with better oxygen use and vascular tone.
Top 5 Clinically Supported Benefits
1) Endurance & aerobic performance (VO₂, time-to-exhaustion)
Double-blind RCTs report improved aerobic capacity and exercise outcomes with Cs-4/Cordyceps over 6–12 weeks in older adults and amateur endurance athletes; some trials in trained cyclists are neutral.
“Cordyceps supplementation improved aerobic performance after 12 weeks; heart rate at a fixed workload fell by week 8.” (Savioli et al., 2022 RDBPC in amateur marathoners)
“VO₂peak and ventilatory threshold improved in older adults after 12 weeks of Cs-4 vs placebo.” (Chen et al., 2010, DB-RCT)
Study chips: Dose 2–3 g/day Cs-4 or C. sinensis • Duration 6–12 wk • Endpoints VO₂max/VT, HR at submax, TTE • Design DB-RCTs; mixed results in highly trained cohorts.
2) Heart health & endothelial support
Signals include lower exercise HR at matched workload in athletes and mechanistic support for endothelial NO (eNOS) activation with cordycepin derivatives; broader reviews outline cardioprotective actions (ischemia models).
“By 8 weeks, heart rate at the same moderate intensity dropped with Cordyceps vs placebo.” (Savioli et al., 2022)
“Cordycepin derivatives increased eNOS activity via AMPK/Akt and improved endothelial function in vivo.” (IMM-H007 studies)
Study chips: Dose 2 g/day C. sinensis (athletes) • Duration 8–12 wk • Endpoints exercise HR, vascular signaling • Design DB-RCT + mechanistic preclinical; human cardio outcomes still emerging.
3) Skin radiance & photoprotection (preclinical)
Cordyceps extracts show UVB-protective and antioxidant effects in human keratinocytes/experimental models; cosmeceutical reviews highlight anti-photoaging potential. Human cosmetic trials are limited to early/exploratory work.
Study chips: Forms mycelial/fruiting-body extracts • Models keratinocyte, ex vivo/in vivo • Endpoints CPDs, oxidative-stress pathways • Design preclinical; human data needed.
4) Immune modulation (healthy adults)
A 2024 randomized, controlled clinical trial of a C. militaris functional beverage in healthy adults reported modulation of immune responses vs control, supporting an immune-balancing role in humans.
Study chips: Form C. militaris beverage (fermentation-derived) • Duration several weeks • Endpoints immune cell/marker shifts • Design RCT in healthy adults.
5) Metabolic support (glucose—preliminary human data)
A single-blind, randomized, placebo-controlled study using C. cicadae mycelium in hyperglycemic/T2D adults showed improvements in glycemic measures vs placebo, aligning with the genus’ metabolic signals (species vary).
Study chips: Dose freeze-dried mycelium (species: C. cicadae) • Duration weeks • Endpoints fasting glucose/HbA1c (study-specific) • Design randomized, placebo-controlled; confirmatory trials needed.
Summary
Human randomized trials—especially in older or recreational athletes—suggest Cordyceps can improve aerobic performance and lower exercise HR at a set workload, with immune modulation seen in healthy adults. Mechanistic and preclinical lines support endothelial NO, antioxidant, and photoprotective actions; robust human data for skin outcomes and cardiometabolic endpoints are still developing. For best translation, use standardized fruiting-body extracts (β-glucans/cordycepin) from verified species and run them consistently for 6–12 weeks in alignment with RCTs.
Why choose Organica
- Clinically aligned formats (capsules or beverage concepts) and 6–12 week protocols.
- Root-cause sourcing: fruiting-body–based C. militaris/sinensis; optional cordycepin and ≥20% β-glucans specs.
- Third-party COA (species ID by DNA/HPLC, β-glucans, cordycepin; heavy metals, microbes, pesticides, solvents).
- cGMP small-batch, vegan capsules; clean excipients.
References
- Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590.
https://files.achs.edu/course_pdfs/herb504_effect_cs_4_exercise_performance.pdf - Savioli, F. P., et al. (2022). Effects of Cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine, 34, 100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392 - Yao, L., et al. (2024). Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular diseases—Mechanisms and evidence. Journal of Ethnopharmacology.
https://www.sciencedirect.com/science/article/pii/S0378874124006202 - Jiang, S., et al. (2019). The cordycepin derivative IMM-H007 improves endothelial dysfunction by activating AMPK/Akt/eNOS. European Journal of Pharmacology.
https://www.sciencedirect.com/science/article/pii/S0014299919301475 - Ontawong, A., et al. (2024). A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific Reports, 14, 7994.
https://www.nature.com/articles/s41598-024-58742-z.pdf - Hwang, E., et al. (2011). Photoprotective potential of Cordyceps polysaccharides against UVB-induced DNA damage. British Journal of Dermatology, 164(5), 980–982.
https://academic.oup.com/bjd/article/164/5/980/6642964 - Peng, C., et al. (2019). Protective effects of cultivated Cordyceps against UVB-induced damage in human keratinocytes. Journal of Dermatological Science.
https://www.sciencedirect.com/science/article/pii/S0753332219352229 - Hsu, C.-H., et al. (2017). Clinical evaluation of blood glucose regulation with Cordyceps cicadae mycelium in hyperglycemic patients: A randomized, placebo-controlled trial. Journal of Food and Nutrition Research, 5(2).
https://pubs.sciepub.com/jfnr/5/2/10/index.html
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition, take anticoagulants, are pregnant/breastfeeding, or have mushroom allergies, consult a clinician before use.
Cordyceps
Organica’s Cordyceps capsules deliver a clinically validated to enhance aerobic capacity, optimize heart‐healthy lipid.
Cordyceps
Origin:
Cordyceps (primarily Cordyceps sinensis/Ophiocordyceps and Cordyceps militaris) is an entomopathogenic fungus long used in Traditional Chinese Medicine for vitality and endurance. Modern products use cultured fruiting bodies or standardized extracts (often β-glucans/cordycepin) in capsule, beverage, or powder forms.
How it works
Key actives—cordycepin (3′-deoxyadenosine), adenosine analogs, and polysaccharides—appear to support mitochondrial energy and endothelial NO signaling, while providing antioxidant/anti-inflammatory activity. Cordycepin derivatives have been shown to activate AMPK-Akt-eNOS and boost nitric-oxide bioavailability in vascular cells/animal models—consistent with better oxygen use and vascular tone.
Top 5 Clinically Supported Benefits
1) Endurance & aerobic performance (VO₂, time-to-exhaustion)
Double-blind RCTs report improved aerobic capacity and exercise outcomes with Cs-4/Cordyceps over 6–12 weeks in older adults and amateur endurance athletes; some trials in trained cyclists are neutral.
“Cordyceps supplementation improved aerobic performance after 12 weeks; heart rate at a fixed workload fell by week 8.” (Savioli et al., 2022 RDBPC in amateur marathoners)
“VO₂peak and ventilatory threshold improved in older adults after 12 weeks of Cs-4 vs placebo.” (Chen et al., 2010, DB-RCT)
Study chips: Dose 2–3 g/day Cs-4 or C. sinensis • Duration 6–12 wk • Endpoints VO₂max/VT, HR at submax, TTE • Design DB-RCTs; mixed results in highly trained cohorts.
2) Heart health & endothelial support
Signals include lower exercise HR at matched workload in athletes and mechanistic support for endothelial NO (eNOS) activation with cordycepin derivatives; broader reviews outline cardioprotective actions (ischemia models).
“By 8 weeks, heart rate at the same moderate intensity dropped with Cordyceps vs placebo.” (Savioli et al., 2022)
“Cordycepin derivatives increased eNOS activity via AMPK/Akt and improved endothelial function in vivo.” (IMM-H007 studies)
Study chips: Dose 2 g/day C. sinensis (athletes) • Duration 8–12 wk • Endpoints exercise HR, vascular signaling • Design DB-RCT + mechanistic preclinical; human cardio outcomes still emerging.
3) Skin radiance & photoprotection (preclinical)
Cordyceps extracts show UVB-protective and antioxidant effects in human keratinocytes/experimental models; cosmeceutical reviews highlight anti-photoaging potential. Human cosmetic trials are limited to early/exploratory work.
Study chips: Forms mycelial/fruiting-body extracts • Models keratinocyte, ex vivo/in vivo • Endpoints CPDs, oxidative-stress pathways • Design preclinical; human data needed.
4) Immune modulation (healthy adults)
A 2024 randomized, controlled clinical trial of a C. militaris functional beverage in healthy adults reported modulation of immune responses vs control, supporting an immune-balancing role in humans.
Study chips: Form C. militaris beverage (fermentation-derived) • Duration several weeks • Endpoints immune cell/marker shifts • Design RCT in healthy adults.
5) Metabolic support (glucose—preliminary human data)
A single-blind, randomized, placebo-controlled study using C. cicadae mycelium in hyperglycemic/T2D adults showed improvements in glycemic measures vs placebo, aligning with the genus’ metabolic signals (species vary).
Study chips: Dose freeze-dried mycelium (species: C. cicadae) • Duration weeks • Endpoints fasting glucose/HbA1c (study-specific) • Design randomized, placebo-controlled; confirmatory trials needed.
Summary
Human randomized trials—especially in older or recreational athletes—suggest Cordyceps can improve aerobic performance and lower exercise HR at a set workload, with immune modulation seen in healthy adults. Mechanistic and preclinical lines support endothelial NO, antioxidant, and photoprotective actions; robust human data for skin outcomes and cardiometabolic endpoints are still developing. For best translation, use standardized fruiting-body extracts (β-glucans/cordycepin) from verified species and run them consistently for 6–12 weeks in alignment with RCTs.
Why choose Organica
- Clinically aligned formats (capsules or beverage concepts) and 6–12 week protocols.
- Root-cause sourcing: fruiting-body–based C. militaris/sinensis; optional cordycepin and ≥20% β-glucans specs.
- Third-party COA (species ID by DNA/HPLC, β-glucans, cordycepin; heavy metals, microbes, pesticides, solvents).
- cGMP small-batch, vegan capsules; clean excipients.
References
- Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590.
https://files.achs.edu/course_pdfs/herb504_effect_cs_4_exercise_performance.pdf - Savioli, F. P., et al. (2022). Effects of Cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine, 34, 100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392 - Yao, L., et al. (2024). Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular diseases—Mechanisms and evidence. Journal of Ethnopharmacology.
https://www.sciencedirect.com/science/article/pii/S0378874124006202 - Jiang, S., et al. (2019). The cordycepin derivative IMM-H007 improves endothelial dysfunction by activating AMPK/Akt/eNOS. European Journal of Pharmacology.
https://www.sciencedirect.com/science/article/pii/S0014299919301475 - Ontawong, A., et al. (2024). A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific Reports, 14, 7994.
https://www.nature.com/articles/s41598-024-58742-z.pdf - Hwang, E., et al. (2011). Photoprotective potential of Cordyceps polysaccharides against UVB-induced DNA damage. British Journal of Dermatology, 164(5), 980–982.
https://academic.oup.com/bjd/article/164/5/980/6642964 - Peng, C., et al. (2019). Protective effects of cultivated Cordyceps against UVB-induced damage in human keratinocytes. Journal of Dermatological Science.
https://www.sciencedirect.com/science/article/pii/S0753332219352229 - Hsu, C.-H., et al. (2017). Clinical evaluation of blood glucose regulation with Cordyceps cicadae mycelium in hyperglycemic patients: A randomized, placebo-controlled trial. Journal of Food and Nutrition Research, 5(2).
https://pubs.sciepub.com/jfnr/5/2/10/index.html
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition, take anticoagulants, are pregnant/breastfeeding, or have mushroom allergies, consult a clinician before use.
Supporting Ingredients
Cordyceps
Cordyceps
Origin:
Cordyceps (primarily Cordyceps sinensis/Ophiocordyceps and Cordyceps militaris) is an entomopathogenic fungus long used in Traditional Chinese Medicine for vitality and endurance. Modern products use cultured fruiting bodies or standardized extracts (often β-glucans/cordycepin) in capsule, beverage, or powder forms.
How it works
Key actives—cordycepin (3′-deoxyadenosine), adenosine analogs, and polysaccharides—appear to support mitochondrial energy and endothelial NO signaling, while providing antioxidant/anti-inflammatory activity. Cordycepin derivatives have been shown to activate AMPK-Akt-eNOS and boost nitric-oxide bioavailability in vascular cells/animal models—consistent with better oxygen use and vascular tone.
Top 5 Clinically Supported Benefits
1) Endurance & aerobic performance (VO₂, time-to-exhaustion)
Double-blind RCTs report improved aerobic capacity and exercise outcomes with Cs-4/Cordyceps over 6–12 weeks in older adults and amateur endurance athletes; some trials in trained cyclists are neutral.
“Cordyceps supplementation improved aerobic performance after 12 weeks; heart rate at a fixed workload fell by week 8.” (Savioli et al., 2022 RDBPC in amateur marathoners)
“VO₂peak and ventilatory threshold improved in older adults after 12 weeks of Cs-4 vs placebo.” (Chen et al., 2010, DB-RCT)
Study chips: Dose 2–3 g/day Cs-4 or C. sinensis • Duration 6–12 wk • Endpoints VO₂max/VT, HR at submax, TTE • Design DB-RCTs; mixed results in highly trained cohorts.
2) Heart health & endothelial support
Signals include lower exercise HR at matched workload in athletes and mechanistic support for endothelial NO (eNOS) activation with cordycepin derivatives; broader reviews outline cardioprotective actions (ischemia models).
“By 8 weeks, heart rate at the same moderate intensity dropped with Cordyceps vs placebo.” (Savioli et al., 2022)
“Cordycepin derivatives increased eNOS activity via AMPK/Akt and improved endothelial function in vivo.” (IMM-H007 studies)
Study chips: Dose 2 g/day C. sinensis (athletes) • Duration 8–12 wk • Endpoints exercise HR, vascular signaling • Design DB-RCT + mechanistic preclinical; human cardio outcomes still emerging.
3) Skin radiance & photoprotection (preclinical)
Cordyceps extracts show UVB-protective and antioxidant effects in human keratinocytes/experimental models; cosmeceutical reviews highlight anti-photoaging potential. Human cosmetic trials are limited to early/exploratory work.
Study chips: Forms mycelial/fruiting-body extracts • Models keratinocyte, ex vivo/in vivo • Endpoints CPDs, oxidative-stress pathways • Design preclinical; human data needed.
4) Immune modulation (healthy adults)
A 2024 randomized, controlled clinical trial of a C. militaris functional beverage in healthy adults reported modulation of immune responses vs control, supporting an immune-balancing role in humans.
Study chips: Form C. militaris beverage (fermentation-derived) • Duration several weeks • Endpoints immune cell/marker shifts • Design RCT in healthy adults.
5) Metabolic support (glucose—preliminary human data)
A single-blind, randomized, placebo-controlled study using C. cicadae mycelium in hyperglycemic/T2D adults showed improvements in glycemic measures vs placebo, aligning with the genus’ metabolic signals (species vary).
Study chips: Dose freeze-dried mycelium (species: C. cicadae) • Duration weeks • Endpoints fasting glucose/HbA1c (study-specific) • Design randomized, placebo-controlled; confirmatory trials needed.
Summary
Human randomized trials—especially in older or recreational athletes—suggest Cordyceps can improve aerobic performance and lower exercise HR at a set workload, with immune modulation seen in healthy adults. Mechanistic and preclinical lines support endothelial NO, antioxidant, and photoprotective actions; robust human data for skin outcomes and cardiometabolic endpoints are still developing. For best translation, use standardized fruiting-body extracts (β-glucans/cordycepin) from verified species and run them consistently for 6–12 weeks in alignment with RCTs.
Why choose Organica
- Clinically aligned formats (capsules or beverage concepts) and 6–12 week protocols.
- Root-cause sourcing: fruiting-body–based C. militaris/sinensis; optional cordycepin and ≥20% β-glucans specs.
- Third-party COA (species ID by DNA/HPLC, β-glucans, cordycepin; heavy metals, microbes, pesticides, solvents).
- cGMP small-batch, vegan capsules; clean excipients.
References
- Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590.
https://files.achs.edu/course_pdfs/herb504_effect_cs_4_exercise_performance.pdf - Savioli, F. P., et al. (2022). Effects of Cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine, 34, 100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392 - Yao, L., et al. (2024). Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular diseases—Mechanisms and evidence. Journal of Ethnopharmacology.
https://www.sciencedirect.com/science/article/pii/S0378874124006202 - Jiang, S., et al. (2019). The cordycepin derivative IMM-H007 improves endothelial dysfunction by activating AMPK/Akt/eNOS. European Journal of Pharmacology.
https://www.sciencedirect.com/science/article/pii/S0014299919301475 - Ontawong, A., et al. (2024). A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific Reports, 14, 7994.
https://www.nature.com/articles/s41598-024-58742-z.pdf - Hwang, E., et al. (2011). Photoprotective potential of Cordyceps polysaccharides against UVB-induced DNA damage. British Journal of Dermatology, 164(5), 980–982.
https://academic.oup.com/bjd/article/164/5/980/6642964 - Peng, C., et al. (2019). Protective effects of cultivated Cordyceps against UVB-induced damage in human keratinocytes. Journal of Dermatological Science.
https://www.sciencedirect.com/science/article/pii/S0753332219352229 - Hsu, C.-H., et al. (2017). Clinical evaluation of blood glucose regulation with Cordyceps cicadae mycelium in hyperglycemic patients: A randomized, placebo-controlled trial. Journal of Food and Nutrition Research, 5(2).
https://pubs.sciepub.com/jfnr/5/2/10/index.html
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition, take anticoagulants, are pregnant/breastfeeding, or have mushroom allergies, consult a clinician before use.
Clinical Research on Cordyceps
Cordyceps
Cordyceps
Origin:
Cordyceps (primarily Cordyceps sinensis/Ophiocordyceps and Cordyceps militaris) is an entomopathogenic fungus long used in Traditional Chinese Medicine for vitality and endurance. Modern products use cultured fruiting bodies or standardized extracts (often β-glucans/cordycepin) in capsule, beverage, or powder forms.
How it works
Key actives—cordycepin (3′-deoxyadenosine), adenosine analogs, and polysaccharides—appear to support mitochondrial energy and endothelial NO signaling, while providing antioxidant/anti-inflammatory activity. Cordycepin derivatives have been shown to activate AMPK-Akt-eNOS and boost nitric-oxide bioavailability in vascular cells/animal models—consistent with better oxygen use and vascular tone.
Top 5 Clinically Supported Benefits
1) Endurance & aerobic performance (VO₂, time-to-exhaustion)
Double-blind RCTs report improved aerobic capacity and exercise outcomes with Cs-4/Cordyceps over 6–12 weeks in older adults and amateur endurance athletes; some trials in trained cyclists are neutral.
“Cordyceps supplementation improved aerobic performance after 12 weeks; heart rate at a fixed workload fell by week 8.” (Savioli et al., 2022 RDBPC in amateur marathoners)
“VO₂peak and ventilatory threshold improved in older adults after 12 weeks of Cs-4 vs placebo.” (Chen et al., 2010, DB-RCT)
Study chips: Dose 2–3 g/day Cs-4 or C. sinensis • Duration 6–12 wk • Endpoints VO₂max/VT, HR at submax, TTE • Design DB-RCTs; mixed results in highly trained cohorts.
2) Heart health & endothelial support
Signals include lower exercise HR at matched workload in athletes and mechanistic support for endothelial NO (eNOS) activation with cordycepin derivatives; broader reviews outline cardioprotective actions (ischemia models).
“By 8 weeks, heart rate at the same moderate intensity dropped with Cordyceps vs placebo.” (Savioli et al., 2022)
“Cordycepin derivatives increased eNOS activity via AMPK/Akt and improved endothelial function in vivo.” (IMM-H007 studies)
Study chips: Dose 2 g/day C. sinensis (athletes) • Duration 8–12 wk • Endpoints exercise HR, vascular signaling • Design DB-RCT + mechanistic preclinical; human cardio outcomes still emerging.
3) Skin radiance & photoprotection (preclinical)
Cordyceps extracts show UVB-protective and antioxidant effects in human keratinocytes/experimental models; cosmeceutical reviews highlight anti-photoaging potential. Human cosmetic trials are limited to early/exploratory work.
Study chips: Forms mycelial/fruiting-body extracts • Models keratinocyte, ex vivo/in vivo • Endpoints CPDs, oxidative-stress pathways • Design preclinical; human data needed.
4) Immune modulation (healthy adults)
A 2024 randomized, controlled clinical trial of a C. militaris functional beverage in healthy adults reported modulation of immune responses vs control, supporting an immune-balancing role in humans.
Study chips: Form C. militaris beverage (fermentation-derived) • Duration several weeks • Endpoints immune cell/marker shifts • Design RCT in healthy adults.
5) Metabolic support (glucose—preliminary human data)
A single-blind, randomized, placebo-controlled study using C. cicadae mycelium in hyperglycemic/T2D adults showed improvements in glycemic measures vs placebo, aligning with the genus’ metabolic signals (species vary).
Study chips: Dose freeze-dried mycelium (species: C. cicadae) • Duration weeks • Endpoints fasting glucose/HbA1c (study-specific) • Design randomized, placebo-controlled; confirmatory trials needed.
Summary
Human randomized trials—especially in older or recreational athletes—suggest Cordyceps can improve aerobic performance and lower exercise HR at a set workload, with immune modulation seen in healthy adults. Mechanistic and preclinical lines support endothelial NO, antioxidant, and photoprotective actions; robust human data for skin outcomes and cardiometabolic endpoints are still developing. For best translation, use standardized fruiting-body extracts (β-glucans/cordycepin) from verified species and run them consistently for 6–12 weeks in alignment with RCTs.
Why choose Organica
- Clinically aligned formats (capsules or beverage concepts) and 6–12 week protocols.
- Root-cause sourcing: fruiting-body–based C. militaris/sinensis; optional cordycepin and ≥20% β-glucans specs.
- Third-party COA (species ID by DNA/HPLC, β-glucans, cordycepin; heavy metals, microbes, pesticides, solvents).
- cGMP small-batch, vegan capsules; clean excipients.
References
- Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–590.
https://files.achs.edu/course_pdfs/herb504_effect_cs_4_exercise_performance.pdf - Savioli, F. P., et al. (2022). Effects of Cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine, 34, 100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392 - Yao, L., et al. (2024). Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular diseases—Mechanisms and evidence. Journal of Ethnopharmacology.
https://www.sciencedirect.com/science/article/pii/S0378874124006202 - Jiang, S., et al. (2019). The cordycepin derivative IMM-H007 improves endothelial dysfunction by activating AMPK/Akt/eNOS. European Journal of Pharmacology.
https://www.sciencedirect.com/science/article/pii/S0014299919301475 - Ontawong, A., et al. (2024). A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults. Scientific Reports, 14, 7994.
https://www.nature.com/articles/s41598-024-58742-z.pdf - Hwang, E., et al. (2011). Photoprotective potential of Cordyceps polysaccharides against UVB-induced DNA damage. British Journal of Dermatology, 164(5), 980–982.
https://academic.oup.com/bjd/article/164/5/980/6642964 - Peng, C., et al. (2019). Protective effects of cultivated Cordyceps against UVB-induced damage in human keratinocytes. Journal of Dermatological Science.
https://www.sciencedirect.com/science/article/pii/S0753332219352229 - Hsu, C.-H., et al. (2017). Clinical evaluation of blood glucose regulation with Cordyceps cicadae mycelium in hyperglycemic patients: A randomized, placebo-controlled trial. Journal of Food and Nutrition Research, 5(2).
https://pubs.sciepub.com/jfnr/5/2/10/index.html
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition, take anticoagulants, are pregnant/breastfeeding, or have mushroom allergies, consult a clinician before use.
Why Choose Our Cordyceps
Key Benefits
Fruiting-Body Only – Concentrated actives from mature fruiting body; excludes mycelium, grain
Fruiting-Body Only – Concentrated actives from mature fruiting body; excludes mycelium, grain
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Standardized Cordycepin – Verified accurate cordycepin/adenosine content by third party labs
Standardized Cordycepin – Verified accurate cordycepin/adenosine content by third party labs
Water Extraction – Solvent-free hot-water process preserving polysaccharides and nucleosides
Water Extraction – Solvent-free hot-water process preserving polysaccharides and nucleosides
Proven & Peer-Reviewed – Supported by research for performance, heart health, and radiance
Proven & Peer-Reviewed – Supported by research for performance, heart health, and radiance
Freshly Bottled – Sealed promptly after extraction for peak freshness, no stockpiled bulk
Freshly Bottled – Sealed promptly after extraction for peak freshness, no stockpiled bulk
Ethical Farming – Supports small family farms, not industrial or exploitative suppliers
Ethical Farming – Supports small family farms, not industrial or exploitative suppliers
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
No Fillers or Additives – 100% Cordyceps extract with nothing added, no fillers or flow agents
No Fillers or Additives – 100% Cordyceps extract with nothing added, no fillers or flow agents
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Workout Recovery
Jennifer Frankforth
Sustained Energy
Marcus Lee
Beautiful Skin
Stacy Rumov
Endurance Lift
Jordan Blake
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Reviews
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Zane L.
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Didn’t Click for Me
Didn’t click for me. I’m going back to basics—sleep and walks. (1★)
Eloise J.
Stairs Don’t Win Anymore
Climbing stairs at work doesn’tfeel like a set piece anymore.
Viktor R.
Already Reordered
I reordered after finishing the bottle because the routine just works.
Marco U.
Source Looks Clean
Label and sourcing look clean. The extract tastes neutral.
Write Review
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Cordyceps - Frequently Asked Questions
Organica’s Cordyceps capsules contain 500 mg of Ophiocordyceps sinensis Cs-4 extract per capsule, standardized to 7 % cordycepin and 20 % β-glucan polysaccharides for reliable bioactive potency and efficacy.
In a 6-week RCT, older adults taking 3 g/day of Cs-4 extract experienced a 7.6 % increase in VO₂ max and reported greater exercise tolerance and reduced fatigue compared with placebo.
A 12-week study in hyperlipidemic patients found that 2 g/day of Cs-4 extract lowered LDL-C by 18 % and raised HDL-C by 12 %, indicating improved lipid profiles and potential cardioprotective benefits.
In a 12-week pilot trial of middle-aged women, 1.5 g/day of Cs-4 extract reduced wrinkle depth by 15 % and increased skin hydration by 22 % versus baseline, reflecting improved skin barrier function.
We recommend taking one 500 mg capsule twice daily with meals (1 g total per day), matching clinical protocols that demonstrated performance, cardiovascular, and skin health benefits.
We recommend taking one 500 mg capsule twice daily with meals (1 g total per day), matching clinical protocols that demonstrated performance, cardiovascular, and skin health benefits.
