Other Ingredients: Vegetable Cellulose (Veggie Capsule)
Every Organica product is crafted with a purity-first promise—100% plant-based, vegan, and free from GMOs, fillers, and artificial additives. Each batch is third-party tested to ensure clean, effective wellness you can trust in every capsule.
Supports faster bounce-back from immune strain, stress, or illness with revitalizing nutrients and herbs.
Supports your body’s natural ability to stay strong, adaptive, and protected against daily immune stressors.
Neutralizes harmful free radicals to shield immune cells and tissues from oxidative damage.
Promotes a well-regulated immune state—neither overactive nor sluggish—through adaptogens and micronutrients.
Helps regulate internal systems and supports a calm, steady response to everyday physical demands.
Helps fortify your body’s frontline defenses against seasonal threats and environmental stressors.
Helps fortify your body’s frontline defenses against seasonal threats and environmental stressors.
Supports faster bounce-back from immune strain, stress, or illness with revitalizing nutrients and herbs.
Supports your body’s natural ability to stay strong, adaptive, and protected against daily immune stressors.
Neutralizes harmful free radicals to shield immune cells and tissues from oxidative damage.
Promotes a well-regulated immune state—neither overactive nor sluggish—through adaptogens and micronutrients.
Helps regulate internal systems and supports a calm, steady response to everyday physical demands.
Dark-berry anthocyanins that bolster seasonal upper-airway defenses.
Origin: Elderberry (Sambucus nigra L.) — standardized fruit extract used for immune defense, daily recovery, and antioxidant support, with growing human evidence for shortening upper-respiratory symptom duration and easing severity. Modern products declare total anthocyanins (e.g., ≥15–20%) and use 4–12-week protocols during high-exposure seasons.
Phytochemical Profile
1) Shorter URTI Duration (daily recovery)
A 2019 meta-analysis of randomized, controlled trials found elderberry supplementation significantly reduced the duration of upper-respiratory symptoms compared with control.
Study chips: Typical daily 300–900 mg fruit extract (standardized) • 5–12 days during illness or 4–12 weeks seasonally • Endpoints symptom days/severity • Design DB-RCTs/meta-analysis.
2) Lower Symptom Severity (immune defense you can feel)
Across RCTs included in the 2018–2021 evidence base, elderberry groups showed reduced global symptom scores (nasal congestion, cough, aches) versus placebo—supporting faster daily recovery.
Study chips: Standardized extracts/syrups • 5–10 days during symptomatic periods • Endpoints composite symptom scales, rescue-meds use • DB-RCTs.
3) Immune Balance (cytokine modulation)
Human and translational studies report modulation—not overstimulation—of cytokines (e.g., directionally supporting early innate responses while limiting oxidative stress), aligning with immune balance rather than a blunt up-regulation.
Study chips: 2–4 weeks+ • Endpoints select cytokines/chemokines, WBC subsets • Randomized/controlled; small cohorts.
4) Antioxidant Capacity (daily resilience)
Controlled human trials with elderberry beverages/extracts show increases in total antioxidant capacity (TAC) and reductions in oxidative-stress markers, consistent with its dense anthocyanin profile.
Study chips: 1–8 weeks • Endpoints TAC, SOD/GPx, lipid peroxidation • Randomized/controlled.
5) Tolerability & Safety Signals
Across RCTs and meta-analyses, standardized elderberry was well tolerated with adverse events comparable to placebo—supporting seasonal, daily use in wellness stacks.
Study chips: Up to 12 weeks • Endpoints AE rates, discontinuations • DB-RCTs/meta-analyses.
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
https://www.mdpi.com/journal/nutrients
https://academic.oup.com/advances
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/antioxidants
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Do not ingest raw or unripe elder parts (cyanogenic glycosides). Standardized extracts are generally well tolerated; discuss with a clinician if pregnant/nursing, immunocompromised, or on anticoagulants.
Stabilizes mast cells production and supports sinus comfort.
Origin: Quercetin — standardized flavonol (typically from Sophora japonica) used for immune defense, daily resilience/recovery, antioxidant support, and immune balance/inflammation reduction. Modern supplements use quercetin anhydrous/dihydrate, or enhanced-bioavailability forms (e.g., Quercetin Phytosome/Quercefit®, EMIQ/isoquercitrin) at ~250–500 mg/day (anhydrous equivalents), often paired with bromelain or vitamin C.
Phytochemical Profile
1) Inflammation Reduction (CRP, IL-6, TNF-α)
Meta-analyses of randomized trials in adults with metabolic/inflammatory risk show reductions in hs-CRP, IL-6, and TNF-α with quercetin versus placebo—effect sizes modest but significant.
Study chips: 250–1,000 mg/day (or bioavailable equivalents) • 8–12 wk • Endpoints CRP/hs-CRP, IL-6, TNF-α • Design DB-RCTs; pooled analyses.
Benefit tags: immune balance · inflammation reduction
2) Antioxidant Capacity (TAC ↑; oxidative stress ↓)
Human RCTs report higher total antioxidant capacity (TAC) and lower lipid peroxidation (e.g., MDA/TBARS) with quercetin supplementation—consistent with Nrf2/HO-1 activation.
Study chips: 250–500 mg/day • 4–12 wk • Endpoints TAC, SOD/GPx, MDA/TBARS • Randomized/controlled.
Benefit tags: antioxidant · daily resilience
3) Upper-Respiratory Symptom Load (adjunct human signals)
Recent controlled trials (including combination formulas with vitamin C ± bromelain) show reduced URTI symptom days/severity or fewer sick days, while some trials of quercetin alone are neutral—overall signal favors adjunctive use for daily recovery.
Study chips: 500–1,000 mg/day quercetin (or bioavailable equivalent), sometimes with vitamin C/bromelain • 2–12 wk • Endpoints symptom days, composite scores, sick-days • DB-RCTs.
Benefit tags: immune defense · daily recovery
4) Allergy/Upper-Airway Comfort (mast-cell stabilization)
Pilot RCTs and controlled studies report improved nasal/ocular symptom scores in seasonal-allergy contexts with bioavailable quercetin—consistent with histamine moderation and local anti-inflammatory effects.
Study chips: ~250–500 mg/day (bioavailable forms favored) • 2–8 wk • Endpoints TNSS/eye symptom scales, rescue-meds use • Randomized/controlled.
Benefit tags: immune balance · daily resilience
5) Cardiometabolic Support (secondary but supportive)
Meta-analyses since 2018 indicate small reductions in SBP/DBP and improved glycemic markers in at-risk adults—reflecting systemic anti-inflammatory/antioxidant effects that underpin everyday immune resilience.
Study chips: 500–1,000 mg/day • 8–12 wk • Endpoints SBP/DBP, FBG/HbA1c • DB-RCTs/meta-analyses.
Benefit tags: inflammation reduction · antioxidant
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/nutrients
https://www.mdpi.com/journal/antioxidants
https://www.sciencedirect.com/journal/clinical-nutrition
• https://academic.oup.com/nutritionreviews
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
• https://www.hindawi.com/journals/ecam/
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Medication cautions: quercetin may affect drug metabolism (e.g., CYP3A4/P-gp); consult a clinician if using anticoagulants, chemotherapy, antibiotics, or other critical meds. Not recommended in pregnancy/nursing without medical guidance.
Prebiotic larch fiber that strengthens mucosal immunity.
Arabinogalactan (from Larch, Larix spp.) — standardized prebiotic polysaccharide used for immune defense, daily recovery/resilience, immune balance, inflammation reduction, and antioxidant support. Modern products use highly soluble, low-viscosity fibers composed of β-1,3 galactan backbones with arabinosyl side chains; they dissolve clear, are mildly sweet, and are well tolerated.
Phytochemical Profile
1) Fewer or Shorter Upper-Respiratory Episodes (daily recovery/defense)
Randomized, placebo-controlled trials in healthy adults during winter report lower incidence and/or shorter duration of common-cold–type episodes with daily larch arabinogalactan versus placebo.
Study chips: 1.5–4.5 g/day, 8–12 weeks (seasonal) • Endpoints URTI incidence, symptom days, global severity • DB-RCTs; pooled updates.
2) Mucosal Immunity (sIgA) & Immune Readiness
Controlled human studies show higher salivary secretory IgA (sIgA) with arabinogalactan supplementation—consistent with stronger first-line mucosal defense during high-exposure periods.
Study chips: 1.5–4.5 g/day, 4–8 weeks • Endpoints sIgA, illness logs • Randomized/controlled.
3) Vaccine Response (adjunct signal)
In healthy adults, arabinogalactan used around vaccination has shown enhanced antibody responses to selected antigens in controlled trials—supporting a role in immune readiness (population- and antigen-dependent).
Study chips: 1.5–4.5 g/day, 4–8 weeks around vaccination • Endpoints IgG titers, seroconversion • Randomized/controlled.
4) Immune Balance & Inflammation Reduction
Human trials report directionally favorable changes in CRP and pro-inflammatory cytokines (e.g., IL-6/TNF-α) with arabinogalactan, aligning with SCFA-mediated signaling and Nrf2 antioxidant pathways.
Study chips: 1.5–4.5 g/day, 6–12 weeks • Endpoints CRP, IL-6/TNF-α, TAC • Randomized/controlled; small–moderate cohorts.
5) Antioxidant & Gut-Barrier Support (daily resilience)
Prebiotic fermentation increases butyrate/propionate, which correlate with higher total antioxidant capacity and tight-junction support—helping maintain everyday resilience and comfort (gas/bloating typically mild/transient).
Study chips: 1.5–4.5 g/day, 4–8 weeks • Endpoints SCFAs, TAC, GI comfort • Randomized/controlled.
https://www.mdpi.com/journal/nutrients
https://nutritionandmetabolism.biomedcentral.com/
• https://link.springer.com/journal/394
https://www.tandfonline.com/toc/uacn20/current
• https://www.dovepress.com/clinical-interventions-in-aging-journal
https://www.frontiersin.org/journals/immunology
• https://www.frontiersin.org/journals/microbiology
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
• https://onlinelibrary.wiley.com/journal/10991573
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Tolerability: generally excellent; mild gas/bloating can occur initially. Medication cautions: none typical at supplement doses, but individuals with immunosuppressive therapy/transplant should consult a clinician before use.
Traditional seed extract that supports balanced immunity.
Origin: Nigella (Nigella sativa) — standardized seed extract used for immune defense, daily recovery/resilience, antioxidant support, and immune balance/inflammation reduction. Modern products use seed extract or oil standardized for thymoquinone (TQ) (commonly 2.5–5% TQ) at ~250–500 mg/day extract (or 500–1,000 mg/day oil) over 4–12 weeks.
Phytochemical Profile
1) Inflammation Reduction (CRP, IL-6, TNF-α)
Meta-analyses of randomized trials in adults with inflammatory/metabolic risk show significant reductions in hs-CRP, IL-6, and TNF-α with Nigella sativa vs placebo (effect sizes modest but consistent).
Study chips: 250–2,000 mg/day (oil or TQ-std. extract) • 8–12 wk • Endpoints CRP/IL-6/TNF-α • DB-RCTs; meta-analyses.
2) Antioxidant Capacity (TAC ↑; oxidative stress ↓)
Human RCTs report higher total antioxidant capacity and lower lipid peroxidation (MDA/TBARS) after nigella, aligning with Nrf2/HO-1 activation by TQ.
Study chips: 500–1,000 mg/day • 4–12 wk • Endpoints TAC, SOD/GPx, MDA/TBARS • Randomized/controlled.
3) Immune Balance (allergy/upper-airway comfort)
Trials in allergic rhinitis and related upper-airway irritation show improved nasal/ocular symptom scores and lower IgE/eosinophil markers, consistent with mast-cell stabilization and balanced Th1/Th2 responses.
Study chips: 250–500 mg/day extract or 500–1,000 mg/day oil • 2–8 wk • Endpoints TNSS, IgE, eosinophils • DB-RCTs/controlled.
4) Respiratory Symptom Burden & Daily Recovery (adjunct)
Controlled studies—including seasonal wellness and adjunct settings—report lighter cough/congestion and quicker return to routine, supporting daily recovery during high-exposure periods.
Study chips: 500–1,000 mg/day • 2–8 wk • Endpoints composite symptom scores, sick-days • Randomized/controlled.
5) Cardiometabolic Co-benefits (supportive for resilience)
Meta-analyses indicate small improvements in SBP/DBP, lipids (↓ LDL-C/TG), and glycemic markers—systemic effects that underpin everyday immune resilience and inflammation control.
Study chips: 1–2 g/day oil or ~500 mg/day extract • 8–12 wk • Endpoints SBP/DBP, LDL-C/TG, FBG/HbA1c • DB-RCTs/meta-analyses.
https://www.mdpi.com/journal/nutrients
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/antioxidants
https://www.hindawi.com/journals/ecam/
https://www.sciencedirect.com/journal/clinical-nutrition
• https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Medication cautions: may have additive effects with anticoagulants/antiplatelets, antihypertensives, or glucose-lowering drugs. Avoid in pregnancy; consult a clinician if nursing or on chronic medications.
Origin: Pelargonium (Pelargonium sidoides) — standardized root extract used for immune defense, daily recovery, and inflammation reduction, with consistent human evidence for shortening upper-respiratory symptom duration and easing cough/throat discomfort. Most clinical work uses an EPs-style root extract; adult protocols commonly span 7–10 days during acute episodes (capsules/tablets or liquid), and 2–3 weeks in high-exposure periods.
Phytochemical Profile
1) Faster Daily Recovery (URTI duration & severity ↓)
Randomized, placebo-controlled trials and meta-analyses show shorter duration and lower overall severity of common-cold/acute bronchitis symptoms with standardized P. sidoides vs placebo. Benefits typically appear within 2–3 days and accumulate over 7–10 days.
Study chips: ~60 mg/day EPs-style extract (or labeled equivalent) • 7–10 days • Endpoints symptom-day counts, composite severity, rescue-meds use • DB-RCTs; meta-analyses.
2) Cough & Throat Comfort
Trials consistently report reduced cough frequency/severity, easier expectoration, and less throat pain, supporting daily recovery and return to normal activity.
Study chips: same as above • Endpoints cough scores, sputum ease, throat-pain VAS • DB-RCTs.
3) Immune Defense / Fewer Complications (adjunctive signal)
Across controlled studies, P. sidoides groups show lower odds of symptom progression and fewer “rescue” medications (e.g., antitussives/antibiotics)—consistent with improved immune efficiency and airway clearance.
Study chips: 7–10 days • Endpoints treatment failures, adjunct medication rates, physician-rated improvement • DB-RCTs; pooled analyses.
4) Inflammation Reduction & Antioxidant Support
Human and translational data indicate decreases in inflammatory indices (e.g., CRP trends in at-risk cohorts) and improved antioxidant capacity, aligning with NF-κB down-modulation and phenolic antioxidant activity.
Study chips: 1–3 weeks • Endpoints CRP/IL-6 (study-specific), TAC/MDA • Randomized/controlled; small–moderate cohorts.
5) Daily Resilience (function & well-being)
Patient-reported outcomes show quicker return to normal routine, less sleep disruption from cough, and improved global well-being during seasonal use.
Study chips: 1–3 weeks • Endpoints global wellness, activity scales, sleep impact • RCTs/controlled studies.
https://www.journals.elsevier.com/phytomedicine
• https://onlinelibrary.wiley.com/journal/10991573
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
https://www.mdpi.com/journal/nutrients
https://www.frontiersin.org/journals/pharmacology
https://www.journals.elsevier.com/advances-in-integrative-medicine
• https://www.hindawi.com/journals/ecam/
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Avoid if pregnant/nursing. Use caution with anticoagulants/antiplatelets or bleeding disorders. Rare GI upset or allergic reactions can occur; discontinue if adverse symptoms appear.
Origin: Astragalus (Astragalus membranaceus) — standardized root extract used for immune defense, daily resilience/recovery, and immune balance. Modern products declare polysaccharides (e.g., ≥16–40%) and sometimes astragaloside IV (e.g., ≥0.5%) on the COA; protocols span seasonal daily use (4–12 weeks) and acute support at first signs.
Phytochemical Profile
1) Immune Defense: fewer URTI episodes/shorter duration
Randomized and controlled human studies using standardized astragalus report lower incidence of common colds over seasonal windows and/or shorter symptom duration versus placebo or routine care.
Study chips: 200–600 mg/day extract (or 1–3 g/day root equivalent) • 4–12 wk • Endpoints URTI incidence, symptom days/severity • Design DB-RCTs/controlled trials.
2) Daily Resilience & Recovery
Trials in at-risk adults (e.g., high-stress/older) show improvements in well-being/fatigue indices and faster return to normal function during cold season when astragalus is taken preventively.
Study chips: 200–500 mg/day • 6–12 wk • Endpoints fatigue scales, global well-being, sick-days • Design randomized/controlled.
3) Immune Balance (cytokines) & Inflammation Reduction
Human studies report directionally favorable changes in CRP, IL-6, and TNF-α, consistent with NF-κB modulation and a balanced (not overstimulated) immune profile.
Study chips: 200–600 mg/day • 4–12 wk • Endpoints CRP, IL-6, TNF-α • Design randomized/controlled; small–moderate cohorts.
4) Antioxidant Capacity (TAC, SOD/GPx)
Supplementation has been associated with higher total antioxidant capacity and upregulated SOD/GPx with lower lipid peroxidation (MDA/TBARS)—supporting daily resilience.
Study chips: 200–500 mg/day • 4–8 wk • Endpoints TAC, SOD/GPx, MDA/TBARS • Design randomized/controlled.
5) Vaccine/Antibody Response (adjunct signals)
Pilot human studies indicate enhanced antibody titers or immune-readiness markers when astragalus is used as a seasonal adjunct (population- and vaccine-dependent; confirmation ongoing).
Study chips: 200–500 mg/day • 4–8 wk • Endpoints specific antibody titers, NK activity • Design controlled trials; exploratory
https://www.mdpi.com/journal/nutrients
https://onlinelibrary.wiley.com/journal/10991573
https://www.frontiersin.org/journals/pharmacology
https://www.hindawi.com/journals/ecam/
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• https://www.elsevier.com/journals/integrative-medicine-research
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Avoid use with immunosuppressive therapy/transplant unless supervised. Consult a clinician if pregnant/nursing or on anticoagulants.
Andrographis (Andrographis paniculata) — standardized aerial-part extract used for immune defense, daily recovery, and inflammation reduction, with consistent human data for shortening upper-respiratory symptom duration and easing severity. Modern products declare andrographolides (e.g., ≥20%) on the COA; protocols span acute 5–10 days and seasonal 4–12 weeks.
Phytochemical Profile
1) Faster Daily Recovery (URTI duration ↓, severity ↓)
Meta-analyses and randomized, placebo-controlled trials report shorter duration and lower severity of common-cold/URTI symptoms (sore throat, cough, nasal symptoms, fever) with standardized andrographis versus placebo.
Study chips: 200–400 mg/day extract (≥20% andrographolides) • 5–10 days acute use • Endpoints symptom days, composite severity, rescue-meds • DB-RCTs; meta-analyses.
2) Immune Defense / Fewer Episodes (seasonal use)
Controlled human studies show reduced incidence or fewer sick-days across high-exposure seasons when andrographis is taken preventively.
Study chips: 200–600 mg/day • 4–12 weeks • Endpoints URTI incidence, sick-days, absenteeism • Randomized/controlled.
3) Inflammation Reduction & Throat Comfort
Trials document greater reductions in throat pain scores, cough intensity/frequency, and fever days, aligning with NF-κB/COX-2 modulation and local anti-inflammatory actions.
Study chips: 200–400 mg/day • 5–10 days • Endpoints pain VAS, cough scores, fever days • DB-RCTs.
4) Antioxidant / Daily Resilience (marker support)
Human studies (ill and at-risk adults) report improvements in oxidative-stress markers and directionally favorable shifts in CRP/IL-6, consistent with andrographolide-driven redox and cytokine balance.
Study chips: 200–600 mg/day • 2–8 weeks • Endpoints TAC, MDA/TBARS, CRP/IL-6 • Randomized/controlled; small-to-moderate cohorts.
5) Tolerability & Safety Signals
Standardized extracts are generally well tolerated in RCTs, with AE rates similar to placebo (most often mild GI upset or transient headache).
Study chips: Up to 12 weeks • Endpoints AEs, discontinuations • DB-RCTs/meta-analyses.
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/nutrients
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
https://www.sciencedirect.com/journal/journal-of-herbal-medicine
• https://www.journals.elsevier.com/phytomedicine
https://www.frontiersin.org/journals/pharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Not for pregnancy or breastfeeding. Use caution with anticoagulants/antiplatelets (additive effects possible). Stop 1–2 weeks before surgery unless advised. Rare hypersensitivity or taste changes can occur; discontinue if rash or persistent GI upset develops.
Arabinogalactan (from Larch, Larix spp.) — standardized prebiotic polysaccharide used for immune defense, daily recovery/resilience, immune balance, inflammation reduction, and antioxidant support. Modern products use highly soluble, low-viscosity fibers composed of β-1,3 galactan backbones with arabinosyl side chains; they dissolve clear, are mildly sweet, and are well tolerated.
Phytochemical Profile
1) Fewer or Shorter Upper-Respiratory Episodes (daily recovery/defense)
Randomized, placebo-controlled trials in healthy adults during winter report lower incidence and/or shorter duration of common-cold–type episodes with daily larch arabinogalactan versus placebo.
Study chips: 1.5–4.5 g/day, 8–12 weeks (seasonal) • Endpoints URTI incidence, symptom days, global severity • DB-RCTs; pooled updates.
2) Mucosal Immunity (sIgA) & Immune Readiness
Controlled human studies show higher salivary secretory IgA (sIgA) with arabinogalactan supplementation—consistent with stronger first-line mucosal defense during high-exposure periods.
Study chips: 1.5–4.5 g/day, 4–8 weeks • Endpoints sIgA, illness logs • Randomized/controlled.
3) Vaccine Response (adjunct signal)
In healthy adults, arabinogalactan used around vaccination has shown enhanced antibody responses to selected antigens in controlled trials—supporting a role in immune readiness (population- and antigen-dependent).
Study chips: 1.5–4.5 g/day, 4–8 weeks around vaccination • Endpoints IgG titers, seroconversion • Randomized/controlled.
4) Immune Balance & Inflammation Reduction
Human trials report directionally favorable changes in CRP and pro-inflammatory cytokines (e.g., IL-6/TNF-α) with arabinogalactan, aligning with SCFA-mediated signaling and Nrf2 antioxidant pathways.
Study chips: 1.5–4.5 g/day, 6–12 weeks • Endpoints CRP, IL-6/TNF-α, TAC • Randomized/controlled; small–moderate cohorts.
5) Antioxidant & Gut-Barrier Support (daily resilience)
Prebiotic fermentation increases butyrate/propionate, which correlate with higher total antioxidant capacity and tight-junction support—helping maintain everyday resilience and comfort (gas/bloating typically mild/transient).
Study chips: 1.5–4.5 g/day, 4–8 weeks • Endpoints SCFAs, TAC, GI comfort • Randomized/controlled.
https://www.mdpi.com/journal/nutrients
https://nutritionandmetabolism.biomedcentral.com/
• https://link.springer.com/journal/394
https://www.tandfonline.com/toc/uacn20/current
• https://www.dovepress.com/clinical-interventions-in-aging-journal
https://www.frontiersin.org/journals/immunology
• https://www.frontiersin.org/journals/microbiology
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
• https://onlinelibrary.wiley.com/journal/10991573
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Tolerability: generally excellent; mild gas/bloating can occur initially. Medication cautions: none typical at supplement doses, but individuals with immunosuppressive therapy/transplant should consult a clinician before use.
Origin: Pelargonium (Pelargonium sidoides) — standardized root extract used for immune defense, daily recovery, and inflammation reduction, with consistent human evidence for shortening upper-respiratory symptom duration and easing cough/throat discomfort. Most clinical work uses an EPs-style root extract; adult protocols commonly span 7–10 days during acute episodes (capsules/tablets or liquid), and 2–3 weeks in high-exposure periods.
Phytochemical Profile
1) Faster Daily Recovery (URTI duration & severity ↓)
Randomized, placebo-controlled trials and meta-analyses show shorter duration and lower overall severity of common-cold/acute bronchitis symptoms with standardized P. sidoides vs placebo. Benefits typically appear within 2–3 days and accumulate over 7–10 days.
Study chips: ~60 mg/day EPs-style extract (or labeled equivalent) • 7–10 days • Endpoints symptom-day counts, composite severity, rescue-meds use • DB-RCTs; meta-analyses.
2) Cough & Throat Comfort
Trials consistently report reduced cough frequency/severity, easier expectoration, and less throat pain, supporting daily recovery and return to normal activity.
Study chips: same as above • Endpoints cough scores, sputum ease, throat-pain VAS • DB-RCTs.
3) Immune Defense / Fewer Complications (adjunctive signal)
Across controlled studies, P. sidoides groups show lower odds of symptom progression and fewer “rescue” medications (e.g., antitussives/antibiotics)—consistent with improved immune efficiency and airway clearance.
Study chips: 7–10 days • Endpoints treatment failures, adjunct medication rates, physician-rated improvement • DB-RCTs; pooled analyses.
4) Inflammation Reduction & Antioxidant Support
Human and translational data indicate decreases in inflammatory indices (e.g., CRP trends in at-risk cohorts) and improved antioxidant capacity, aligning with NF-κB down-modulation and phenolic antioxidant activity.
Study chips: 1–3 weeks • Endpoints CRP/IL-6 (study-specific), TAC/MDA • Randomized/controlled; small–moderate cohorts.
5) Daily Resilience (function & well-being)
Patient-reported outcomes show quicker return to normal routine, less sleep disruption from cough, and improved global well-being during seasonal use.
Study chips: 1–3 weeks • Endpoints global wellness, activity scales, sleep impact • RCTs/controlled studies.
https://www.journals.elsevier.com/phytomedicine
• https://onlinelibrary.wiley.com/journal/10991573
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
https://www.mdpi.com/journal/nutrients
https://www.frontiersin.org/journals/pharmacology
https://www.journals.elsevier.com/advances-in-integrative-medicine
• https://www.hindawi.com/journals/ecam/
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Avoid if pregnant/nursing. Use caution with anticoagulants/antiplatelets or bleeding disorders. Rare GI upset or allergic reactions can occur; discontinue if adverse symptoms appear.
Origin: Quercetin — standardized flavonol (typically from Sophora japonica) used for immune defense, daily resilience/recovery, antioxidant support, and immune balance/inflammation reduction. Modern supplements use quercetin anhydrous/dihydrate, or enhanced-bioavailability forms (e.g., Quercetin Phytosome/Quercefit®, EMIQ/isoquercitrin) at ~250–500 mg/day (anhydrous equivalents), often paired with bromelain or vitamin C.
Phytochemical Profile
1) Inflammation Reduction (CRP, IL-6, TNF-α)
Meta-analyses of randomized trials in adults with metabolic/inflammatory risk show reductions in hs-CRP, IL-6, and TNF-α with quercetin versus placebo—effect sizes modest but significant.
Study chips: 250–1,000 mg/day (or bioavailable equivalents) • 8–12 wk • Endpoints CRP/hs-CRP, IL-6, TNF-α • Design DB-RCTs; pooled analyses.
Benefit tags: immune balance · inflammation reduction
2) Antioxidant Capacity (TAC ↑; oxidative stress ↓)
Human RCTs report higher total antioxidant capacity (TAC) and lower lipid peroxidation (e.g., MDA/TBARS) with quercetin supplementation—consistent with Nrf2/HO-1 activation.
Study chips: 250–500 mg/day • 4–12 wk • Endpoints TAC, SOD/GPx, MDA/TBARS • Randomized/controlled.
Benefit tags: antioxidant · daily resilience
3) Upper-Respiratory Symptom Load (adjunct human signals)
Recent controlled trials (including combination formulas with vitamin C ± bromelain) show reduced URTI symptom days/severity or fewer sick days, while some trials of quercetin alone are neutral—overall signal favors adjunctive use for daily recovery.
Study chips: 500–1,000 mg/day quercetin (or bioavailable equivalent), sometimes with vitamin C/bromelain • 2–12 wk • Endpoints symptom days, composite scores, sick-days • DB-RCTs.
Benefit tags: immune defense · daily recovery
4) Allergy/Upper-Airway Comfort (mast-cell stabilization)
Pilot RCTs and controlled studies report improved nasal/ocular symptom scores in seasonal-allergy contexts with bioavailable quercetin—consistent with histamine moderation and local anti-inflammatory effects.
Study chips: ~250–500 mg/day (bioavailable forms favored) • 2–8 wk • Endpoints TNSS/eye symptom scales, rescue-meds use • Randomized/controlled.
Benefit tags: immune balance · daily resilience
5) Cardiometabolic Support (secondary but supportive)
Meta-analyses since 2018 indicate small reductions in SBP/DBP and improved glycemic markers in at-risk adults—reflecting systemic anti-inflammatory/antioxidant effects that underpin everyday immune resilience.
Study chips: 500–1,000 mg/day • 8–12 wk • Endpoints SBP/DBP, FBG/HbA1c • DB-RCTs/meta-analyses.
Benefit tags: inflammation reduction · antioxidant
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/nutrients
https://www.mdpi.com/journal/antioxidants
https://www.sciencedirect.com/journal/clinical-nutrition
• https://academic.oup.com/nutritionreviews
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
• https://www.hindawi.com/journals/ecam/
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Medication cautions: quercetin may affect drug metabolism (e.g., CYP3A4/P-gp); consult a clinician if using anticoagulants, chemotherapy, antibiotics, or other critical meds. Not recommended in pregnancy/nursing without medical guidance.
Origin: Nigella (Nigella sativa) — standardized seed extract used for immune defense, daily recovery/resilience, antioxidant support, and immune balance/inflammation reduction. Modern products use seed extract or oil standardized for thymoquinone (TQ) (commonly 2.5–5% TQ) at ~250–500 mg/day extract (or 500–1,000 mg/day oil) over 4–12 weeks.
Phytochemical Profile
1) Inflammation Reduction (CRP, IL-6, TNF-α)
Meta-analyses of randomized trials in adults with inflammatory/metabolic risk show significant reductions in hs-CRP, IL-6, and TNF-α with Nigella sativa vs placebo (effect sizes modest but consistent).
Study chips: 250–2,000 mg/day (oil or TQ-std. extract) • 8–12 wk • Endpoints CRP/IL-6/TNF-α • DB-RCTs; meta-analyses.
2) Antioxidant Capacity (TAC ↑; oxidative stress ↓)
Human RCTs report higher total antioxidant capacity and lower lipid peroxidation (MDA/TBARS) after nigella, aligning with Nrf2/HO-1 activation by TQ.
Study chips: 500–1,000 mg/day • 4–12 wk • Endpoints TAC, SOD/GPx, MDA/TBARS • Randomized/controlled.
3) Immune Balance (allergy/upper-airway comfort)
Trials in allergic rhinitis and related upper-airway irritation show improved nasal/ocular symptom scores and lower IgE/eosinophil markers, consistent with mast-cell stabilization and balanced Th1/Th2 responses.
Study chips: 250–500 mg/day extract or 500–1,000 mg/day oil • 2–8 wk • Endpoints TNSS, IgE, eosinophils • DB-RCTs/controlled.
4) Respiratory Symptom Burden & Daily Recovery (adjunct)
Controlled studies—including seasonal wellness and adjunct settings—report lighter cough/congestion and quicker return to routine, supporting daily recovery during high-exposure periods.
Study chips: 500–1,000 mg/day • 2–8 wk • Endpoints composite symptom scores, sick-days • Randomized/controlled.
5) Cardiometabolic Co-benefits (supportive for resilience)
Meta-analyses indicate small improvements in SBP/DBP, lipids (↓ LDL-C/TG), and glycemic markers—systemic effects that underpin everyday immune resilience and inflammation control.
Study chips: 1–2 g/day oil or ~500 mg/day extract • 8–12 wk • Endpoints SBP/DBP, LDL-C/TG, FBG/HbA1c • DB-RCTs/meta-analyses.
https://www.mdpi.com/journal/nutrients
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/antioxidants
https://www.hindawi.com/journals/ecam/
https://www.sciencedirect.com/journal/clinical-nutrition
• https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Medication cautions: may have additive effects with anticoagulants/antiplatelets, antihypertensives, or glucose-lowering drugs. Avoid in pregnancy; consult a clinician if nursing or on chronic medications.
Origin: Astragalus (Astragalus membranaceus) — standardized root extract used for immune defense, daily resilience/recovery, and immune balance. Modern products declare polysaccharides (e.g., ≥16–40%) and sometimes astragaloside IV (e.g., ≥0.5%) on the COA; protocols span seasonal daily use (4–12 weeks) and acute support at first signs.
Phytochemical Profile
1) Immune Defense: fewer URTI episodes/shorter duration
Randomized and controlled human studies using standardized astragalus report lower incidence of common colds over seasonal windows and/or shorter symptom duration versus placebo or routine care.
Study chips: 200–600 mg/day extract (or 1–3 g/day root equivalent) • 4–12 wk • Endpoints URTI incidence, symptom days/severity • Design DB-RCTs/controlled trials.
2) Daily Resilience & Recovery
Trials in at-risk adults (e.g., high-stress/older) show improvements in well-being/fatigue indices and faster return to normal function during cold season when astragalus is taken preventively.
Study chips: 200–500 mg/day • 6–12 wk • Endpoints fatigue scales, global well-being, sick-days • Design randomized/controlled.
3) Immune Balance (cytokines) & Inflammation Reduction
Human studies report directionally favorable changes in CRP, IL-6, and TNF-α, consistent with NF-κB modulation and a balanced (not overstimulated) immune profile.
Study chips: 200–600 mg/day • 4–12 wk • Endpoints CRP, IL-6, TNF-α • Design randomized/controlled; small–moderate cohorts.
4) Antioxidant Capacity (TAC, SOD/GPx)
Supplementation has been associated with higher total antioxidant capacity and upregulated SOD/GPx with lower lipid peroxidation (MDA/TBARS)—supporting daily resilience.
Study chips: 200–500 mg/day • 4–8 wk • Endpoints TAC, SOD/GPx, MDA/TBARS • Design randomized/controlled.
5) Vaccine/Antibody Response (adjunct signals)
Pilot human studies indicate enhanced antibody titers or immune-readiness markers when astragalus is used as a seasonal adjunct (population- and vaccine-dependent; confirmation ongoing).
Study chips: 200–500 mg/day • 4–8 wk • Endpoints specific antibody titers, NK activity • Design controlled trials; exploratory
https://www.mdpi.com/journal/nutrients
https://onlinelibrary.wiley.com/journal/10991573
https://www.frontiersin.org/journals/pharmacology
https://www.hindawi.com/journals/ecam/
https://www.sciencedirect.com/journal/journal-of-ethnopharmacology
• https://www.elsevier.com/journals/integrative-medicine-research
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Avoid use with immunosuppressive therapy/transplant unless supervised. Consult a clinician if pregnant/nursing or on anticoagulants.
Andrographis (Andrographis paniculata) — standardized aerial-part extract used for immune defense, daily recovery, and inflammation reduction, with consistent human data for shortening upper-respiratory symptom duration and easing severity. Modern products declare andrographolides (e.g., ≥20%) on the COA; protocols span acute 5–10 days and seasonal 4–12 weeks.
Phytochemical Profile
1) Faster Daily Recovery (URTI duration ↓, severity ↓)
Meta-analyses and randomized, placebo-controlled trials report shorter duration and lower severity of common-cold/URTI symptoms (sore throat, cough, nasal symptoms, fever) with standardized andrographis versus placebo.
Study chips: 200–400 mg/day extract (≥20% andrographolides) • 5–10 days acute use • Endpoints symptom days, composite severity, rescue-meds • DB-RCTs; meta-analyses.
2) Immune Defense / Fewer Episodes (seasonal use)
Controlled human studies show reduced incidence or fewer sick-days across high-exposure seasons when andrographis is taken preventively.
Study chips: 200–600 mg/day • 4–12 weeks • Endpoints URTI incidence, sick-days, absenteeism • Randomized/controlled.
3) Inflammation Reduction & Throat Comfort
Trials document greater reductions in throat pain scores, cough intensity/frequency, and fever days, aligning with NF-κB/COX-2 modulation and local anti-inflammatory actions.
Study chips: 200–400 mg/day • 5–10 days • Endpoints pain VAS, cough scores, fever days • DB-RCTs.
4) Antioxidant / Daily Resilience (marker support)
Human studies (ill and at-risk adults) report improvements in oxidative-stress markers and directionally favorable shifts in CRP/IL-6, consistent with andrographolide-driven redox and cytokine balance.
Study chips: 200–600 mg/day • 2–8 weeks • Endpoints TAC, MDA/TBARS, CRP/IL-6 • Randomized/controlled; small-to-moderate cohorts.
5) Tolerability & Safety Signals
Standardized extracts are generally well tolerated in RCTs, with AE rates similar to placebo (most often mild GI upset or transient headache).
Study chips: Up to 12 weeks • Endpoints AEs, discontinuations • DB-RCTs/meta-analyses.
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/nutrients
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
https://www.sciencedirect.com/journal/journal-of-herbal-medicine
• https://www.journals.elsevier.com/phytomedicine
https://www.frontiersin.org/journals/pharmacology
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Not for pregnancy or breastfeeding. Use caution with anticoagulants/antiplatelets (additive effects possible). Stop 1–2 weeks before surgery unless advised. Rare hypersensitivity or taste changes can occur; discontinue if rash or persistent GI upset develops.
Origin: Elderberry (Sambucus nigra L.) — standardized fruit extract used for immune defense, daily recovery, and antioxidant support, with growing human evidence for shortening upper-respiratory symptom duration and easing severity. Modern products declare total anthocyanins (e.g., ≥15–20%) and use 4–12-week protocols during high-exposure seasons.
Phytochemical Profile
1) Shorter URTI Duration (daily recovery)
A 2019 meta-analysis of randomized, controlled trials found elderberry supplementation significantly reduced the duration of upper-respiratory symptoms compared with control.
Study chips: Typical daily 300–900 mg fruit extract (standardized) • 5–12 days during illness or 4–12 weeks seasonally • Endpoints symptom days/severity • Design DB-RCTs/meta-analysis.
2) Lower Symptom Severity (immune defense you can feel)
Across RCTs included in the 2018–2021 evidence base, elderberry groups showed reduced global symptom scores (nasal congestion, cough, aches) versus placebo—supporting faster daily recovery.
Study chips: Standardized extracts/syrups • 5–10 days during symptomatic periods • Endpoints composite symptom scales, rescue-meds use • DB-RCTs.
3) Immune Balance (cytokine modulation)
Human and translational studies report modulation—not overstimulation—of cytokines (e.g., directionally supporting early innate responses while limiting oxidative stress), aligning with immune balance rather than a blunt up-regulation.
Study chips: 2–4 weeks+ • Endpoints select cytokines/chemokines, WBC subsets • Randomized/controlled; small cohorts.
4) Antioxidant Capacity (daily resilience)
Controlled human trials with elderberry beverages/extracts show increases in total antioxidant capacity (TAC) and reductions in oxidative-stress markers, consistent with its dense anthocyanin profile.
Study chips: 1–8 weeks • Endpoints TAC, SOD/GPx, lipid peroxidation • Randomized/controlled.
5) Tolerability & Safety Signals
Across RCTs and meta-analyses, standardized elderberry was well tolerated with adverse events comparable to placebo—supporting seasonal, daily use in wellness stacks.
Study chips: Up to 12 weeks • Endpoints AE rates, discontinuations • DB-RCTs/meta-analyses.
https://www.sciencedirect.com/journal/complementary-therapies-in-medicine
https://www.mdpi.com/journal/nutrients
https://academic.oup.com/advances
https://onlinelibrary.wiley.com/journal/10991573
https://www.mdpi.com/journal/antioxidants
Regulatory note: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Do not ingest raw or unripe elder parts (cyanogenic glycosides). Standardized extracts are generally well tolerated; discuss with a clinician if pregnant/nursing, immunocompromised, or on anticoagulants.
Natural Botanicals – Real plant extracts you can pronounce; no harmful ingredients or chemicals
Natural Botanicals – Real plant extracts you can pronounce; no harmful ingredients or chemicals
Multi-Angle Formulation - Cohesively crafted to deliver results from 6 different angles
Multi-Angle Formulation - Cohesively crafted to deliver results from 6 different angles
Proven Real Trials – Backed by extensive peer testing for effective, consistent results
Proven Real Trials – Backed by extensive peer testing for effective, consistent results
Clinically Researched – Backed by rigorous clinical data using only proven ingredients
Clinically Researched – Backed by rigorous clinical data using only proven ingredients
Optimal Bioavailability – Absorption-focused design for reliable uptake and persitant results
Optimal Bioavailability – Absorption-focused design for reliable uptake and persitant results
Ethical Sourcing – Supports small family farms, no industrial or exploitative suppliers
Ethical Sourcing – Supports small family farms, no industrial or exploitative suppliers
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
Glass & Bamboo Packaging – Eco-friendly packaging that protects purity, no harmful plastics
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
QR Code Verified – Scan to see your batch’s lab report and source trail, no hidden supply chains
No Fillers or Additives - Clean formulation without fillers, artificial flavors, or harsh preservatives
No Fillers or Additives - Clean formulation without fillers, artificial flavors, or harsh preservatives
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Vegan & Allergen-Free – No animal products, dairy, soy, gluten, or common allergens
Immune Armor™ combines five clinically researched ingredients: 300 mg Elderberry extract standardized to ≥10 % anthocyanins, 250 mg Echinacea purpurea root extract, 200 mg Vitamin C (as ascorbic acid), 15 mg Zinc (as zinc citrate), and 25 µg Vitamin D₃ per serving. Each component is precisely dosed and quality-tested to ensure consistent potency for broad-spectrum immune support.
Elderberry’s anthocyanins and Echinacea’s alkamides activate macrophages and natural killer cells, increasing phagocytosis and pathogen clearance. Elderberry extract has been shown to reduce influenza symptoms and bolster innate responses, while Echinacea augments macrophage cytokine production via Toll-like receptor pathways
Vitamin C and Echinacea work together to enhance B-cell proliferation and immunoglobulin synthesis. Clinical data indicate that 1 g/day of Vitamin C can improve antibody responses to vaccines and reduce infection risk, while Echinacea supports T-cell signaling crucial for long-term immunity.
Zinc and Vitamin D₃ help maintain balanced inflammatory signaling by inhibiting NF-κB activation and reducing pro-inflammatory cytokines (IL-6, TNF-α). Adequate zinc status has been linked to lower systemic inflammation, and Vitamin D₃ at 25 µg/day downregulates IL-6 production, supporting healthy resolution of immune responses.
Zinc lozenges taken within 24 hours of symptom onset can shorten cold duration by up to two days, reflecting enhanced mucosal defense and viral inhibition. Combined with Vitamin C’s antioxidant protection, Immune Armor™ helps accelerate recovery and restore energy.
Take two capsules daily with meals—one in the morning and one in the evening—to maintain steady nutrient levels. Immune Armor™ is well-tolerated; however, individuals with autoimmune diseases, renal impairment, or on immunosuppressive therapy should consult a healthcare professional before use.